Propolipid
Propolipid is a medicine used to put patients to sleep for operations and other medical procedures, or to make them calm and sleepy without fully sleeping.
Form
injektio/infuusioneste, emulsio
Strength
10 mg/ml
Active Ingredient
Propofol
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
For adults, typically 1.5-2.5 mg/kg for induction of anesthesia and 4-12 mg/kg/hour for maintenance. For sedation, 0.3-4.0 mg/kg/hour is usually sufficient.
Method
Propolipid is given directly into a vein, usually in the back of your hand or forearm, by a doctor using a needle or a thin tube. For longer treatments, a pump might be used.
Important
For intensive care sedation in patients over 16 years old, the infusion rate should not exceed 4.0 mg propofol/kg/hour. The medicine should not be used for more than 7 days for sedation.
Possible Side Effects
COMMON
- •Pain at the injection site (when injected before falling asleep)
- •Slow or fast heartbeat
- •Low blood pressure
- •Changes in breathing (fast breathing, temporary stop in breathing)
- •Hiccups
- •Cough
- •Headache
- •Nausea, vomiting
RARE
- •Swelling and redness or blood clots in the vein near the injection site
- •Body jerks and tremors or seizures
- •Severe allergic reaction (breathing difficulties, skin swelling and redness, hot flashes)
- •Fluid buildup in the lungs causing shortness of breath
- •Unusual urine color
- •Involuntary movements
- •Severe skin and tissue reaction if the medicine is accidentally given outside the vein
- •Prolonged, often painful erection (priapism)
- •Dizziness, chills and feeling cold
- •Agitation
- •Unconsciousness after the procedure (patient recovered without problems)
- •Pancreatitis (inflammation of the pancreas) causing severe abdominal pain (causal link not established)
- •Fever after surgery
- •Abnormal good mood (euphoria)
- •Sexual arousal
- •Irregular heartbeat
- •ECG changes (Brugada syndrome type ECG)
- •Changes in liver size
- •Kidney failure
- •Muscle breakdown (rhabdomyolysis), increased blood acidity, increased blood potassium and fat levels, heart failure
- •Drug abuse (mainly among healthcare professionals)
- •Hepatitis (liver inflammation), acute liver failure (symptoms may include yellow skin and eyes, itching, dark urine, abdominal pain, and liver tenderness, sometimes loss of appetite)
- •When used with lidocaine, rare side effects may include: dizziness, vomiting, drowsiness, seizures, slow heart rate (bradycardia), irregular heartbeat (arrhythmias), shock
Important Warnings
- Do not use Propolipid if you are allergic to propofol, soy, peanuts, or any other ingredient in this medicine.
- Not for sedation in children under 16 years old in intensive care units.
- Tell your doctor if you have severe heart failure or other serious heart problems.
- Inform your doctor if you have heart, lung, kidney, liver disease, epilepsy, high pressure inside your head, changes in blood fat levels, or are dehydrated.
- Do not leave the hospital until you are fully awake. If you go home soon after, you need an escort. Do not drive or operate machinery until the medicine's effects have completely worn off.