Procren Depot PDS
Procren Depot PDS is a synthetic medicine that reduces the body's production of testosterone and estrogen hormones.
Form
injektiokuiva-aine ja liuotin suspensiota varten, esitäytetty ruisku
Strength
11.25 mg
Active Ingredient
Leuprorelin acetate
Manufacturer
AbbVie Oy
How to Use
Dosage
The dose depends on your condition and weight. For men, it's usually 3.75 mg every four weeks, 11.25 mg every 12 weeks, or 30 mg every six months. For women, it's 3.75 mg every four weeks or 11.25 mg every 12 weeks, with limits. For children, the dose is specific to their weight, often 1 ml (3.75 mg or 11.25 mg) once a month or every 3 months.
Method
A doctor or nurse will give you this medicine as an injection under your skin, usually in your stomach, buttock, or thigh.
Important
There is no daily maximum dose, as this medicine is given as an injection less frequently than daily (e.g., monthly or every few months).
Possible Side Effects
COMMON
- •Pain, bruising, inflammation, or hardened lumps at the injection site.
- •Headache.
- •Dizziness.
- •Nausea or vomiting.
- •Rash.
- •Acne.
- •Hot flashes.
- •Mood changes (with long-term use).
- •Depression (with long-term use).
- •Shortness of breath.
- •Increased sweating.
- •Muscle and joint pain.
- •Pain.
- •Swelling (fluid retention).
- •Weakness and tiredness.
- •For men: Testicular shrinkage, erectile dysfunction, and changes in ECG (heart's electrical activity).
- •For women: Vaginal infection, decreased sex drive, breast pain and tenderness, reduced breast size, and vaginal dryness.
- •For children: Abdominal pain/cramps, vaginal bleeding/spotting/discharge.
RARE
- •Weight changes.
- •Vision problems.
- •Chest pressure.
- •Trouble sleeping (insomnia).
- •Severe whole-body allergic reaction (anaphylaxis).
- •Muscle stiffness.
- •Ringing in the ears (tinnitus) or hearing loss.
- •Increased hair growth.
- •Fever.
- •Anemia (low red blood cells).
- •Changes in blood counts.
- •Changes in ECG (heart's electrical activity) or reduced blood flow to the heart.
- •Fast heartbeat (tachycardia).
- •High blood pressure.
- •Unusual sensations (sensory disturbances).
- •Seizures.
- •Loss of appetite (anorexia).
- •Diarrhea.
- •Changes in appetite.
- •Thirst.
- •Constipation.
- •Sore mouth or mouth inflammation (stomatitis).
- •Dry mouth.
- •Itching.
- •Skin symptoms.
- •Hair loss.
- •Nail problems.
- •Abnormal liver test results (e.g., elevated transaminases and phosphatases).
- •Elevated triglyceride, uric acid, or potassium levels in blood.
- •Back and bone pain.
- •Urination problems, increased need to urinate, blood in urine.
- •Elevated urea levels in blood.
- •Pneumonia (lung infection).
- •For men: Breast enlargement.
- •For women: Pain during intercourse, irritability.
- •Interstitial lung disease (a type of lung disease).
- •Severe liver damage or fatty liver (how often this happens is not known).
- •Increased pressure inside the skull (idiopathic intracranial hypertension) with symptoms like headache, double vision, other vision problems, or ringing in the ears.
- •Very rare widespread allergic reactions (fever, rash, itching).
- •Very rare severe allergic reaction causing breathing difficulties or dizziness.
- •Changes in the pituitary gland, which may increase the risk of bleeding or stroke in that area, potentially leading to permanent damage.
Important Warnings
- Do not use if you are allergic to leuprorelin acetate or any other ingredients in this medicine.
- Do not use if you are pregnant, trying to get pregnant, or breastfeeding.
- Do not use if you have unexplained vaginal bleeding.
- If you get severe allergic reactions (like trouble breathing, swelling, dizziness, rash), stop the medicine and call your doctor right away.
- Depression, which can be serious, has been reported. Tell your doctor if you feel depressed during treatment.
Show 3 more warnings
- Call your doctor right away if you or your child gets bad or lasting headaches, vision problems, or ringing in the ears.
- If you notice severe skin reactions like blistering or peeling rashes (e.g., Stevens-Johnson syndrome), stop treatment and seek immediate medical help.
- Talk to your doctor if you have other health issues like spinal metastases, fatty liver, urinary blockages, heart problems (especially irregular heartbeat), high blood sugar, diabetes, or high cholesterol. Women should also talk to their doctor if they have been treated for endometriosis with leuprorelin before.