Pramipexole Orion
Pramipexole Orion helps control body movements by acting on dopamine in the brain, used for Parkinson's disease and restless legs syndrome.
How to Use
Dosage
Take exactly as your doctor tells you. For Parkinson's disease, the dose is usually split into three equal doses daily, starting with 0.088 mg three times a day. For restless legs syndrome, take once a day in the evening, 2-3 hours before sleep, starting with 0.088 mg once a day. Your doctor will adjust the dose slowly.
Method
You can take the tablets with or without food. Swallow the tablets whole with water.
For Parkinson's disease, the maximum daily dose is usually 3.3 mg. For restless legs syndrome, the maximum daily dose is 0.54 mg (0.75 mg pramipexole salt).
Possible Side Effects
- •Involuntary movements (dyskinesia)
- •Feeling sleepy
- •Dizziness
- •Feeling sick (nausea)
- •Headache
- •Constipation
- •Vomiting
- •Low blood pressure
- •Swelling, usually in the legs (edema)
- •Feeling very tired
- •Trouble sleeping (insomnia)
- •Unusual dreams
- •Feeling confused
- •Seeing or hearing things that aren't there (hallucinations)
- •Strong urges to act unusually
- •Problems with eyesight
- •Weight loss or less appetite
- •Worsening restless legs syndrome symptoms (augmentation)
- •Feeling overly worried (paranoia)
- •False beliefs (delusions)
- •Feeling restless
- •Severe confusion or reduced awareness (delirium)
- •Sudden uncontrollable movements (hyperkinesia)
- •Fainting
- •Weight gain
- •Allergic reactions (e.g., skin rash, itching)
- •Heart problems causing breathlessness or swollen ankles (heart failure)
- •Problems with a hormone that controls body water (inappropriate antidiuretic hormone secretion)
- •Shortness of breath
- •Hiccups
- •Lung infection (pneumonia)
- •Feeling extremely excited or happy (mania)
- •Specific strong urges or behaviors that are hard to control, like gambling, overeating, overspending, or increased sexual urges
- •Memory loss
- •Spontaneous erection
Important Warnings
- Do not take this medicine if you are allergic to pramipexole or any other ingredient.
- Tell your doctor if you have kidney problems, heart problems, vision problems, or any mental health issues like hallucinations or psychosis.
- Inform your doctor if you experience unusual movements (dyskinesia) or difficulty keeping your body straight (dystonia), especially if you also take levodopa for Parkinson's.
- This medicine can cause sleepiness or sudden sleep attacks. Do not drive or operate machinery if you feel drowsy or have hallucinations.
- Tell your doctor if you or your family notice unusual urges or behaviors like gambling, overeating, excessive spending, or increased sexual urges.
Show 4 more warnings
- Inform your doctor if you experience confusion, agitation, high mood (mania), or altered awareness (delirium). Also, report symptoms like depression, apathy, anxiety, fatigue, sweating, or pain if they occur when stopping or reducing the dose.
- Be careful with alcohol or other medicines that make you sleepy, as this can affect your ability to drive or use machines.
- Do not stop taking this medicine suddenly, especially if you have Parkinson's disease, as it can cause serious withdrawal symptoms. Your doctor will help you reduce the dose slowly.
- Pramipexole Orion is not recommended for children under 18 years old.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose in moderately severe renal impairment. Common adverse effects include orthostatic hypotension, confusion, sudden episodes of deep sleep, impulse control disorders and lower limb edema.. . (updated 6.10.2025)