Piperacillin/Tazobactam Sandoz
This medicine is an antibiotic that fights many types of bacteria, treating serious infections in different parts of the body.
Form
infuusiokuiva-aine, liuosta varten
Strength
4 g / 0.5 g
Active Ingredient
Piperacillin sodium
Manufacturer
Sandoz A/S
How to Use
Dosage
For adults and adolescents over 12, the usual dose is 4 g/0.5 g given every 6 to 8 hours.
Method
This medicine is given as a 30-minute drip (infusion) into a vein by a doctor or nurse.
Important
The maximum daily dose for adults is 16 g/2 g; a single dose should not exceed 4 g/0.5 g.
Possible Side Effects
COMMON
- •Diarrhea
- •Yeast infection
- •Changes in blood tests like low platelet count, low red blood cells or hemoglobin, and prolonged blood clotting time.
- •Low blood protein levels.
- •Headache, difficulty sleeping.
- •Stomach pain, vomiting, nausea, constipation, upset stomach.
- •Increased liver enzymes in blood.
- •Rash, itching.
- •Abnormal kidney function tests.
- •Fever, reactions at the injection site.
RARE
- •Low white blood cell count, prolonged blood clotting, low blood potassium, low blood sugar.
- •Seizures (especially with high doses or kidney problems).
- •Low blood pressure, vein inflammation (pain or redness where the medicine is injected).
- •Skin redness, skin lesions, hives.
- •Increased bilirubin (a substance from red blood cell breakdown).
- •Muscle and joint pain, chills.
- •Severe drop in white blood cells (agranulocytosis), nosebleeds.
- •Severe colon infection, mouth inflammation.
- •Widespread skin peeling (like toxic epidermal necrolysis).
- •Severe decrease in all blood cells (pancytopenia, neutropenia), premature breakdown of red blood cells (hemolytic anemia), small purple spots on skin (purpura), prolonged bleeding, increased platelets or eosinophils.
- •Allergic reactions, including severe whole-body allergic reactions affecting skin, mucous membranes and organs (e.g., kidneys, liver), or severe skin reactions with fever, swelling, and small fluid-filled blisters (AGEP).
- •Liver inflammation, yellowing of skin or eyes (jaundice).
- •Kidney failure or problems, lung disease with increased eosinophils (a type of white blood cell).
- •Acute confusion, disorientation, and delirium.
Important Warnings
- Do not use this medicine if you are allergic to piperacillin, tazobactam, any other ingredients, or other antibiotics like penicillins or cephalosporins.
- Tell your doctor right away if you have diarrhea before, during, or after treatment. Do not take anti-diarrhea medicine without talking to your doctor first.
- Your doctor may check your kidney function and blood potassium levels if they are low.
- If you have kidney or liver problems or are on dialysis, your doctor might adjust your dose and do regular blood tests.
- Tell your doctor if you take blood thinners or if you experience unexpected bleeding.
Show 5 more warnings
- Tell your doctor immediately if you have seizures during treatment.
- If you suspect your infection is getting worse or you have a new infection, tell your doctor.
- Seek immediate medical help if you develop severe skin rashes, blisters, or peeling skin (like Stevens-Johnson syndrome or toxic epidermal necrolysis), or a widespread rash with fever, swollen glands, and organ problems (DRESS syndrome).
- Get urgent medical attention if you have swelling of your face, lips, tongue, or other body parts.
- Get urgent medical attention if you have shortness of breath or wheezing.