Piperacillin/Tazobactam Reig Jofre
This antibiotic, Piperacillin/Tazobactam Reig Jofre, helps your body fight many different bacterial infections.
How to Use
Dosage
Adults and children over 12: Typically 4 grams of piperacillin and 0.5 grams of tazobactam into a vein every 6–8 hours. Children 2–12 years with abdominal infections: 100 mg piperacillin and 12.5 mg tazobactam per kg of body weight into a vein every 8 hours. Children 2–12 years with low white blood cell count: 80 mg piperacillin and 10 mg tazobactam per kg of body weight into a vein every 6 hours.
Method
A healthcare professional will give you this medicine as an intravenous drip (infusion) over about 30 minutes.
Your doctor will determine a child's dose based on weight, but a single dose must not exceed 4 grams of piperacillin and 0.5 grams of tazobactam. For adults, the maximum daily dose is usually 12–16 grams of piperacillin and 1.5–2 grams of tazobactam.
Possible Side Effects
- •Diarrhea
- •Fungal infection
- •Changes in blood counts (e.g., low platelets, red blood cells, or hemoglobin), abnormal lab tests, prolonged blood clotting time
- •Decreased blood protein
- •Headache, insomnia
- •Stomach pain, vomiting, nausea, constipation, indigestion
- •Increased liver enzymes
- •Rash, itching
- •Abnormal kidney tests
- •Fever, injection site reactions
- •Decreased white blood cells, prolonged blood clotting time
- •Low blood potassium and sugar levels
- •Seizures or convulsions (especially with high doses or kidney problems)
- •Low blood pressure, vein inflammation (tenderness, redness), skin redness
- •Increased bilirubin (a blood pigment)
- •Skin reactions such as redness, lesions, hives
- •Joint and muscle pain
- •Chills
- •Severe drop in white blood cells, nosebleeds
- •Severe colon inflammation, mouth inflammation
- •Widespread skin peeling (toxic epidermal necrolysis)
- •Severe decrease in red and white blood cells and platelets (pancytopenia)
- •Severe allergic reactions, such as Stevens-Johnson syndrome, bullous skin disease, or DRESS syndrome (rash affecting internal organs)
- •Liver inflammation, yellowing of skin or eyes (jaundice)
- •Worsening kidney function or kidney problems
- •Lung disease with increased eosinophils (a type of white blood cell)
- •Confusion and disorientation (delirium)
- •Swelling of the face, lips, tongue, or other body parts
- •Shortness of breath, wheezing, or difficulty breathing
Important Warnings
- Do not use this medicine if you are allergic to piperacillin, tazobactam, penicillins, cephalosporins, or similar antibiotics.
- Tell your doctor immediately if you experience severe diarrhea before, during, or after treatment.
- Inform your doctor if you have low potassium levels in your blood.
- Tell your doctor if you have kidney or liver problems or if you are on dialysis.
- Report to your doctor if you are taking vancomycin (another antibiotic) or blood thinners (anticoagulants), as these may increase the risk of side effects.
Show 3 more warnings
- Tell your doctor if you experience seizures during treatment.
- Contact your doctor if you suspect your infection has worsened or if you develop a new infection.
- Seek immediate medical attention if you have several symptoms like fever, swollen lymph nodes, weakness, dizziness, shortness of breath, bruising, or rash, as these can be signs of a rare, serious immune condition (hemophagocytic lymphohistiocytosis).