Piperacillin/Tazobactam Noridem
This medicine is an antibiotic that helps your body fight different types of bacterial infections.
Form
infuusiokuiva-aine, liuosta varten
Strength
4 g / 0.5 g
Active Ingredient
Piperacillin sodium
Manufacturer
Noridem Enterprises Limited
How to Use
Dosage
For adults and children over 12, the usual dose is 4 g/0.5 g, given into a vein every 6 to 8 hours. For children aged 2-12, the dose depends on their weight and the type of infection, given every 6 or 8 hours.
Method
A doctor or nurse will give you this medicine as a drip (infusion) into one of your veins over 30 minutes.
Important
Your doctor will decide your maximum daily dose. For adults, it can be up to 16 g/2 g per day, given in doses every 6-8 hours. For children, no single dose should be more than 4 g/0.5 g.
Possible Side Effects
COMMON
- •Diarrhea
- •Yeast infection
- •Changes in blood tests (e.g., lower red blood cells or platelets, longer bleeding time)
- •Lower protein levels in blood
- •Headache, difficulty sleeping
- •Stomach pain, vomiting, nausea, constipation, upset stomach
- •Increased liver enzymes (shown in blood tests)
- •Rash, itching
- •Abnormal kidney test results
- •Fever, reaction at the injection site
RARE
- •Further changes in blood tests (e.g., lower white blood cells, longer blood clotting time)
- •Lower blood potassium and sugar levels
- •Seizures (fits), especially with high doses or kidney problems
- •Low blood pressure, inflamed vein (pain or redness), skin redness
- •Increased bilirubin (a substance from red blood cell breakdown)
- •Red skin reactions, skin changes, hives
- •Joint and muscle pain
- •Chills
- •Very low white blood cells, nosebleeds
- •Severe colon inflammation, mouth sores
- •Severe skin peeling (toxic epidermal necrolysis)
- •Serious changes in blood cells (low red, white, or platelets), easy bruising, longer bleeding time
- •Allergic reactions, including severe whole-body reactions
- •Liver inflammation, yellowing of skin or eyes (jaundice)
- •Severe skin reactions, including widespread rash, blistering, and peeling skin (e.g., Stevens-Johnson syndrome, DRESS, AGEP)
- •Poor kidney function or kidney problems
- •A type of lung disease (eosinophilic pneumonia)
- •Confusion, feeling disoriented
Important Warnings
- Tell your doctor if you are allergic to piperacillin, tazobactam, other penicillins, cephalosporins, or any other ingredients in this medicine.
- Tell your doctor if you have kidney or liver problems, or if you are on dialysis.
- Tell your doctor about all other medicines you are taking, especially blood thinners or other antibiotics like vancomycin, as they can interact with this medicine.
- Contact your doctor immediately if you experience severe diarrhea, seizures, or if your infection gets worse or you get a new infection.
- Your doctor may check your blood if you have low potassium levels.
Show 4 more warnings
- Seek urgent medical help if you develop a fever, swollen glands, weakness, dizziness, shortness of breath, bruising, or rash, as these could be signs of a serious immune reaction (HLH).
- If you are pregnant, planning to get pregnant, or breastfeeding, ask your doctor for advice before using this medicine.
- If you have cystic fibrosis, there might be a higher risk of fever and rash.
- This medicine can sometimes cause changes in brain function and seizures.