Piperacillin/Tazobactam Kalceks
This medicine is an antibiotic combining piperacillin and tazobactam to fight a wide range of bacterial infections, including those resistant to other treatments.
Form
infuusiokuiva-aine, liuosta varten
Strength
4 g / 0.5 g
Active Ingredient
Piperacillin sodium
Manufacturer
AS Kalceks
How to Use
Dosage
For adults and children over 12 years: 4 g/0.5 g given intravenously every 6-8 hours. For children aged 2-12 years with abdominal infections: 100 mg/12.5 mg per kg body weight every 8 hours. For children aged 2-12 years with low white blood cells: 80 mg/10 mg per kg body weight every 6 hours. Your doctor will determine the exact dose.
Method
This medicine is given as an infusion (a drip) into a vein by a doctor or nurse over 30 minutes.
Important
Your doctor will determine your maximum daily dose. For children, a single dose should not exceed 4 g/0.5 g.
Possible Side Effects
COMMON
- •Diarrhea
RARE
- •Fungal infection
- •Changes in blood cell counts (lower red blood cells, white blood cells, or platelets; sometimes higher platelets or a type of white blood cell called eosinophils)
- •Trouble sleeping, headache
- •Stomach pain, vomiting, constipation, feeling sick (nausea), indigestion
- •Rash, itching, hives (itchy bumps), red skin reactions, skin damage
- •Fever, reaction at the injection site (like pain or redness)
- •Abnormal blood test results (e.g., lower protein, higher liver enzymes, abnormal kidney values, longer blood clotting time, false positive Coombs test)
- •Low blood potassium
- •Seizures (fits)
- •Low blood pressure, vein inflammation (tenderness or redness), facial flushing
- •Joint and muscle pain
- •Chills
- •Low blood sugar, high bilirubin (a substance from red blood cells), longer blood clotting time
- •Nosebleeds
- •Inflammation of the mouth lining
- •Severe decrease in all blood cell types (red, white, platelets), or specific white blood cells, red blood cell breakdown, increased platelets or eosinophils
- •Allergic reactions (can be severe)
- •Sudden confusion and disorientation (feeling lost)
- •Lung disease with increased eosinophils (a type of white blood cell)
- •Liver inflammation, yellowing of skin or eyes
- •Small, spotted bruises (purpura)
- •Kidney failure and other kidney problems
- •Severe skin reactions like Stevens-Johnson syndrome, toxic epidermal necrolysis, or other blistering/peeling rashes that can be life-threatening
- •Very severe allergic reactions affecting skin, kidneys, or liver (e.g., DRESS syndrome)
- •Skin reaction with fever and fluid-filled blisters over large areas of swollen, red skin (acute generalized exanthematous pustulosis)
- •Swelling of the face, lips, tongue, or other body parts
- •Shortness of breath, wheezing, or difficulty breathing
- •Severe or long-lasting diarrhea with fever or weakness
Important Warnings
- Do not take if you are allergic to piperacillin, tazobactam, penicillins, cephalosporins, or similar antibiotics, as you might also be allergic to this medicine.
- Tell your doctor if you have allergies, a history of diarrhea, low blood potassium, or kidney or liver problems, or if you are on dialysis.
- Also mention if you are taking vancomycin (another antibiotic, as it might increase kidney damage risk) or blood thinners.
- Contact your doctor right away if you experience severe diarrhea during or after treatment, unusual bleeding, seizures, or if you suspect a new infection or worsening of an existing one.
- This medicine can cause a severe immune reaction called hemophagocytic lymphohistiocytosis (HLH). Seek immediate medical help if you have fever, swollen lymph nodes, weakness, dizziness, shortness of breath, bruises, or rash.
Show 3 more warnings
- This medicine is not recommended for children under 2 years old, as there is not enough information about its safety and effectiveness in this age group.
- Tell your doctor or lab staff if you are taking this medicine before any blood or urine tests, as it can affect the results.
- If you are pregnant, breastfeeding, think you might be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine, as it can pass to the baby.