Piperacillin/Tazobactam Fresenius Kabi
This medicine is an antibiotic that combines two drugs, piperacillin and tazobactam, to fight various bacterial infections, including those that are resistant to other treatments.
Form
infuusiokuiva-aine, liuosta varten
Strength
4 g / 0.5 g
Active Ingredient
Piperacillin sodium
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
For adults and children over 12, the usual dose is 4 g/0.5 g, given every 6-8 hours.
Method
This medicine is given as a 30-minute infusion into one of your veins by a doctor or nurse.
Important
The maximum daily dose is usually 16 g/2 g, but your doctor will decide the exact dose for you.
Possible Side Effects
COMMON
- •Diarrhea
- •Yeast infection
- •Changes in blood cells (like fewer platelets or red blood cells, or unusual blood test results), prolonged clotting time
- •Decreased protein in blood
- •Headache, trouble sleeping
- •Stomach pain, vomiting, nausea, constipation, indigestion
- •Increased liver enzyme levels in blood
- •Skin rash, itching
- •Abnormal kidney test results
- •Fever, reaction at the injection site
RARE
- •Decrease in certain white blood cells (leukopenia), prolonged clotting time
- •Low potassium or blood sugar levels
- •Seizures (especially with high doses or kidney problems)
- •Low blood pressure, inflamed veins (tenderness or redness), skin redness
- •Increased levels of bilirubin (a substance from red blood cell breakdown)
- •Red skin reactions, changes in skin appearance, hives
- •Joint and muscle pain, chills
- •Severe decrease in white blood cells (agranulocytosis), nosebleeds
- •Severe inflammation of the colon, mouth sores
- •Widespread skin peeling (toxic epidermal necrolysis)
- •Severe decrease in all blood cells (pancytopenia), premature breakdown of red blood cells, small bruises, prolonged bleeding, increased platelets, increase in a type of white blood cell (eosinophils)
- •Severe allergic reactions, including widespread rash, blisters, skin peeling, and effects on internal organs like kidneys and liver (Stevens-Johnson syndrome, DRESS, acute generalized exanthematous pustulosis)
- •Liver inflammation, yellowing of the skin or eyes
- •Poor kidney function or kidney problems
- •A type of lung disease where certain white blood cells (eosinophils) increase in the lungs
- •Acute confusion or delirium
Important Warnings
- Do not use if you are allergic to piperacillin, tazobactam, any other ingredients, or other antibiotics like penicillin or cephalosporins.
- Tell your doctor right away if you have severe diarrhea before, during, or after treatment. Do not take anti-diarrhea medicine without talking to your doctor first.
- Tell your doctor if you have low potassium levels in your blood.
- Tell your doctor if you have kidney or liver problems or are on dialysis. Your doctor may need to check your kidney function.
- If you take blood thinners or experience unusual bleeding, tell your doctor immediately.
Show 7 more warnings
- Using this medicine with another antibiotic called vancomycin can increase the risk of kidney damage.
- Tell your doctor if you have seizures during treatment.
- Tell your doctor if you think your infection is getting worse or if you develop a new infection.
- Stop using this medicine and see a doctor right away if you get severe skin reactions like widespread rash, blisters, or skin peeling.
- Contact your doctor immediately if you have fever, swollen glands, weakness, dizziness, shortness of breath, bruising, or a rash, as these could be signs of a serious immune condition.
- If you are also taking certain other antibiotics (called aminoglycosides), this medicine must be given separately.
- This medicine contains sodium (salt). Consider this if you are on a low-salt diet.