Piperacillin/Tazobactam Antibiotice
This medicine is a penicillin antibiotic that kills many types of bacteria, including those resistant to other penicillin-type drugs.
Form
infuusiokuiva-aine, liuosta varten
Strength
2 g / 0.25 g
Active Ingredient
Piperacillin sodium
Manufacturer
Antibiotice SA
How to Use
Dosage
For adults and adolescents over 12, the usual dose is 4g/0.5g given into a vein every 6-8 hours. For children aged 2-12, the dose depends on their weight and the type of infection, given every 6-8 hours into a vein.
Method
This medicine is given by a doctor or nurse as a slow drip (infusion) into a vein over 30 minutes.
Important
The maximum daily dose for adults is typically 16g of piperacillin and 2g of tazobactam, split into multiple doses. For children, a single dose will not exceed 4g/0.5g.
Possible Side Effects
COMMON
- •Diarrhea
- •Fungal infection
- •Decrease in platelets
- •Decrease in red blood cells or blood pigment (hemoglobin)
- •Abnormal laboratory test result (positive Coombs test)
- •Prolonged blood clotting time
- •Decrease in blood protein
- •Headache
- •Insomnia (difficulty sleeping)
- •Abdominal pain
- •Vomiting
- •Nausea
- •Constipation
- •Indigestion (upset stomach)
- •Increase in liver enzymes in blood
- •Rash
- •Itching
- •Abnormal kidney blood tests
- •Fever
- •Reaction at injection site
RARE
- •Decrease in white blood cells (leukopenia)
- •Prolonged blood clotting time (prothrombin time)
- •Decreased blood potassium
- •Decreased blood sugar
- •Seizures (convulsions)
- •Low blood pressure
- •Vein inflammation (tenderness or redness in the affected area)
- •Skin redness
- •Increase in a product that breaks down blood pigment (bilirubin)
- •Skin reactions with redness, skin lesions, hives
- •Joint and muscle pain
- •Chills
- •Severe decrease in white blood cells (agranulocytosis)
- •Nosebleed
- •Severe colon infection, inflammation of mouth lining
- •Shedding of the top layer of skin all over the body (toxic epidermal necrolysis)
Important Warnings
- Do not use if you are allergic to piperacillin, tazobactam, or any penicillin-type antibiotics.
- Tell your doctor immediately if you get diarrhea before, during, or after treatment. Do not take anti-diarrhea medicine without talking to your doctor.
- Tell your doctor if you have low potassium levels, kidney problems, liver problems, or are on dialysis. You may need regular blood tests.
- Inform your doctor if you are taking vancomycin (another antibiotic) as this medicine with vancomycin can increase the risk of kidney damage.
- Tell your doctor if you are taking blood thinners or if you experience unexpected bleeding.
Show 3 more warnings
- Tell your doctor if you experience seizures or new/worsening infections during treatment.
- Stop taking this medicine and see a doctor right away if you get severe skin reactions like widespread rash, blisters, peeling skin, fever, or swollen lymph nodes. These could be life-threatening.
- Contact your doctor immediately if you have symptoms like fever, swollen glands, weakness, dizziness, shortness of breath, bruising, or rash, as these could be signs of a serious immune condition (hemophagocytic lymphohistiocytosis).