Pentiro
Pentiro contains three active ingredients (levodopa, carbidopa, and entacapone) in one tablet and is used to treat Parkinson's disease.
Form
tabletti, kalvopäällysteinen
Strength
150 mg / 37.5 mg / 200 mg
Active Ingredient
Levodopa
Manufacturer
STADA Arzneimittel AG
How to Use
Dosage
Your doctor will tell you exactly how many Pentiro tablets to take each day; the dose may change based on your response.
Method
Take one tablet at a time, exactly as prescribed by your doctor, with or without food. Do not split or break the tablets. If taking iron supplements, wait 2-3 hours between doses. Leave at least one hour between Pentiro doses.
Important
Do not take more than 7, 8, or 10 tablets per day, depending on the strength prescribed by your doctor.
Possible Side Effects
COMMON
- •Involuntary movements (dyskinesia)
- •Nausea
- •Harmless red-brown discoloration of urine
- •Muscle pain
- •Diarrhea
- •Urinary tract infection
- •Feeling faint or dizzy due to low blood pressure, high blood pressure
- •Worsening Parkinson's symptoms, dizziness, drowsiness
- •Vomiting, stomach pain and discomfort, heartburn, dry mouth, constipation
- •Difficulty sleeping, hallucinations, confusion, abnormal dreams (including nightmares), tiredness
- •Mood changes – including memory impairment, anxiety, and depression (potentially with suicidal thoughts)
- •Heart or blood vessel events (e.g., chest pain), irregular heartbeat or rhythm
- •Increased tendency to fall
- •Shortness of breath
- •Increased sweating, rash
- •Muscle cramps, leg swelling
- •Blurred vision
- •Anemia (low red blood cell count)
- •Loss of appetite, weight loss
- •Headache, joint pain
RARE
- •Heart attack
- •Gastrointestinal bleeding
- •Blood cell changes that may lead to bleeding, abnormal liver function test results
- •Seizures
- •Agitation
- •Psychotic symptoms
- •Colitis (inflammation of the large intestine)
- •Discoloration of non-urine (e.g., skin, nails, hair, sweat)
- •Difficulty swallowing
- •Inability to urinate
Important Warnings
- Contact your doctor immediately if your muscles become very stiff or twitch strongly, or if you experience shaking, agitation, confusion, fever, fast pulse, or large blood pressure changes.
- Contact your doctor immediately if you experience an allergic reaction, such as hives, itching, rash, or swelling of the face, lips, tongue, or throat, which may cause difficulty breathing or swallowing.
- Do not take this medicine if you are allergic to levodopa, carbidopa, entacapone, soy, peanuts, or any other ingredients.
- Do not take this medicine if you have narrow-angle glaucoma (an eye disease).
- Do not take this medicine if you have a tumor of the adrenal gland.
Show 20 more warnings
- Do not take this medicine if you are using certain types of antidepressants (combinations of selective MAO-A and MAO-B inhibitors, or non-selective MAO inhibitors).
- Do not take this medicine if you have severe liver disease.
- Pentiro should not be used in children or adolescents under 18 years of age.
- Talk to your doctor if you have or have had heart problems (like heart attack or irregular heartbeat), blood vessel problems, asthma, other lung diseases, liver disease, kidney disease, hormone-related disease, stomach ulcer, or seizures.
- Talk to your doctor if you have prolonged diarrhea, as it could be a sign of colon inflammation.
- Talk to your doctor if you have a severe mental disorder, such as psychosis.
- Talk to your doctor if you have chronic open-angle glaucoma, as your dose may need adjustment and your eye pressure monitored.
- Talk to your doctor if you are currently taking antipsychotic medicines (used to treat psychosis).
- Talk to your doctor if you are taking medicines that can cause low blood pressure when standing up, as Pentiro can worsen these effects.
- Talk to your doctor if you feel depressed, have suicidal thoughts, or notice unusual changes in your behavior.
- Talk to your doctor if you feel very sleepy or suddenly fall asleep; do not drive or use machines if this happens.
- Talk to your doctor if you notice new or worsening involuntary movements after starting Pentiro, as your doctor may need to adjust your dose.
- Talk to your doctor if you have diarrhea; your weight may need to be monitored to prevent severe weight loss.
- Talk to your doctor if you develop increasing loss of appetite, weakness, or rapid weight loss over time, as a general medical check-up, including liver tests, may be needed.
- Do not stop taking Pentiro unless your doctor tells you to, as sudden discontinuation can cause unwanted side effects.
- Tell your doctor if you or your family notice you developing urges or cravings to behave in unusual ways, such as gambling, overeating, excessive spending, or unusual or increased sexual urges or thoughts.
- Tell your doctor if you or your family notice you developing dependency-like symptoms, such as a strong urge to take higher doses of Pentiro or other Parkinson's medicines.
- If you need surgery, tell your doctor that you are taking Pentiro.
- If you are pregnant, think you might be pregnant, or are planning a baby, ask your doctor or pharmacist for advice before taking this medicine. Do not breastfeed while using Pentiro.
- Pentiro can cause low blood pressure, dizziness, or drowsiness; be very careful when driving or using machines. If you feel very sleepy or fall asleep suddenly, wait until you are fully awake before driving or operating machinery.
Use in Elderly Patients
Category A
Suitable for older adults. Consider potential interactions especially with antipsychotics and metoclopramide. (updated 6.10.2025)