Pentiro
Pentiro contains three active ingredients (levodopa, carbidopa, and entacapone) and is used to treat Parkinson's disease symptoms by increasing dopamine in the brain.
Form
tabletti, kalvopäällysteinen
Strength
100 mg / 25 mg / 200 mg
Active Ingredient
Levodopa
Manufacturer
STADA Arzneimittel AG
How to Use
Dosage
Your doctor will prescribe the exact dose of Pentiro for your needs. Take one tablet at a time.
Method
Take the tablet whole, with water, with or without food. Ensure there is at least one hour between doses.
Important
Do not take more than 7 to 10 tablets per day, depending on the tablet strength. Always follow your doctor's instructions.
Possible Side Effects
COMMON
- •Involuntary movements (dyskinesia)
- •Feeling sick (nausea)
- •Harmless reddish-brown discoloration of urine
- •Muscle pain
- •Diarrhea
- •Urinary tract infection
- •Feeling faint or dizzy due to low blood pressure, high blood pressure
- •Worsening of Parkinson's disease symptoms, dizziness, drowsiness
- •Vomiting, abdominal pain and discomfort, heartburn, dry mouth, constipation
- •Difficulty sleeping, seeing or hearing things that are not real (hallucinations), confusion, unusual dreams (including nightmares), feeling tired
- •Mood changes (including memory problems, anxiety, and depression with suicidal thoughts)
- •Heart problems (e.g., chest pain), irregular heartbeat or rhythm
- •Increased tendency to fall
- •Shortness of breath
- •Increased sweating, rash
- •Muscle cramps, swelling of the legs or ankles
- •Blurred vision
- •Anemia (low red blood cells)
- •Loss of appetite, weight loss
- •Headache, joint pain
RARE
- •Heart attack
- •Bleeding in the digestive system
- •Changes in blood cells, potentially leading to bleeding
- •Abnormal liver function tests
- •Seizures
- •Agitation
- •Psychotic symptoms
- •Inflammation of the large intestine (colitis)
- •Discoloration of non-urine (e.g., skin, nails, hair, sweat)
- •Difficulty swallowing
- •Inability to urinate
- •Liver inflammation (hepatitis)
- •Itching
- •Dopamine dysregulation syndrome (craving higher doses, unusual involuntary movements, mood swings)
- •Impulse control disorders (e.g., strong urges to gamble, overeat, shop excessively, or increased sexual urges)
Important Warnings
- Do not take if you are allergic to levodopa, carbidopa, entacapone, soy, peanuts, or any other ingredient in this medicine.
- Do not take if you have narrow-angle glaucoma, an adrenal gland tumor, severe liver disease, or are taking certain types of antidepressants.
- Contact your doctor immediately if you develop sudden severe muscle stiffness, twitching, tremors, fever, confusion, or a rapid or irregular heartbeat, as these could be signs of a serious condition.
- Seek immediate medical attention if you experience an allergic reaction, such as hives, itching, rash, swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Be careful when driving or operating machinery if you feel drowsy or fall asleep suddenly, as this medication can affect your alertness.
Show 4 more warnings
- Tell your doctor if you notice unusual urges or changes in behavior, such as excessive gambling, eating, spending, or increased sexual urges.
- Do not stop taking this medication suddenly without your doctor's advice, as it can worsen your symptoms and cause unwanted side effects.
- Pentiro is not recommended for children and adolescents under 18 years of age.
- Do not breastfeed while taking this medication.
Use in Elderly Patients
Category A
Suitable for older adults. Consider potential interactions especially with antipsychotics and metoclopramide. (updated 6.10.2025)