Pazopanib Zentiva
Pazopanib Zentiva is a cancer medicine that works by stopping cancer cells from growing and spreading.
Form
tabletti, kalvopäällysteinen
Strength
200 mg
Active Ingredient
Pazopanib hydrochloride
Manufacturer
Zentiva k.s.
How to Use
Dosage
The usual dose is 800 mg (four 200 mg tablets or two 400 mg tablets) once a day.
Method
Take the tablets whole with water, at least two hours after a meal or one hour before a meal. Do not split or crush them. Take the medicine at about the same time each day.
Important
The maximum daily dose is 800 mg.
Possible Side Effects
COMMON
- •High blood pressure
- •Diarrhea
- •Feeling sick (nausea) or throwing up (vomiting)
- •Stomach ache
- •Not wanting to eat
- •Weight loss
- •Changes in taste or losing your sense of taste
- •Headache
- •Feeling tired or weak
- •Hair color changes or hair loss
- •Skin rash, peeling, or redness on hands and feet
- •Nosebleeds
- •Swelling in your face, hands, ankles, or feet
- •Tingling or numbness in your hands, arms, legs, or feet
RARE
- •Brain swelling (signs like trouble speaking, vision changes, fits, confusion, very high blood pressure)
- •Sudden, very high blood pressure (signs like bad chest pain, headache, blurry vision, confusion, feeling very sick, throwing up, shortness of breath, fits, fainting)
- •Heart problems, heart failure, or heart attack (signs like uneven or fast heartbeat, fainting, chest pain, shortness of breath, swollen legs)
- •Stroke (signs like numbness or weakness on one side of the body, trouble speaking, headache, dizziness)
- •Serious bleeding (e.g., blood in stool or urine, stomach pain, coughing up blood)
- •Holes in the stomach or bowel, or abnormal connections (fistulas) (signs like bad stomach pain, feeling sick/throwing up, fever)
- •Liver problems (signs like yellow skin/eyes, dark urine, tiredness, feeling sick, stomach pain on the right side, easy bruising)
- •Blood clots, especially in the legs (DVT) or lungs (pulmonary embolism) (signs like sharp chest pain, shortness of breath, fast breathing, leg pain, swelling in arms/hands or legs/feet)
- •Tumor lysis syndrome (rapid breakdown of cancer cells, signs like uneven heartbeat, fits, confusion, muscle cramps, less urine)
- •Lung inflammation (signs like shortness of breath or a cough that won't go away)
- •Blurred or decreased vision (due to problems with the back of the eye)
- •Serious infections (signs like fever, flu-like symptoms, trouble breathing, pain when peeing, red/warm/swollen/sore wounds)
Important Warnings
- Do not take Pazopanib Zentiva if you are allergic to pazopanib or any other ingredient in this medicine.
- Tell your doctor if you have heart, liver, or kidney problems, or if you have had heart failure or a heart attack.
- Tell your doctor if you have had bleeding, blood clots, or blood vessel problems (like an aneurysm).
- Tell your doctor if you have had stomach or bowel problems, such as a perforation (hole) or fistula (abnormal connection).
- Tell your doctor if you have thyroid problems.
Show 5 more warnings
- Your blood pressure will be checked regularly, as this medicine can raise it. Tell your doctor if you have high blood pressure.
- If you are scheduled for surgery, tell your doctor. Treatment is usually stopped 7 days before surgery.
- Do not drink grapefruit juice during treatment, as it can increase the risk of side effects.
- Do not use this medicine if you are pregnant or breastfeeding. Use reliable contraception during treatment and for at least 2 weeks after.
- Avoid driving or using machines if you feel dizzy, tired, or weak.