Pazopanib STADA
Pazopanib Stada is a medicine that stops cancer cells from growing and spreading by blocking certain proteins.
Form
tabletti, kalvopäällysteinen
Strength
200 mg
Active Ingredient
Pazopanib hydrochloride
Manufacturer
STADA Arzneimittel AG
How to Use
Dosage
The usual dose is 800 mg once a day. This can be taken as four 200 mg tablets or two 400 mg tablets.
Method
Take this medicine without food. You should take it at least two hours after a meal or one hour before a meal. For example, you can take it two hours after breakfast or one hour before lunch. Take the tablets whole with water. Do not break or crush them. Take it at about the same time each day.
Important
The maximum daily dose is 800 mg.
Possible Side Effects
COMMON
- •High blood pressure
- •Diarrhea
- •Nausea or vomiting (feeling sick)
- •Stomach pain
- •Loss of appetite
- •Weight loss
- •Changes in taste or loss of taste
- •Mouth sores
- •Headache
- •Pain in the area of the tumor
- •Feeling weak or tired
- •Changes in hair color
- •Hair loss or thinning
- •Loss of skin color (pigment)
- •Skin rash, sometimes with peeling
- •Redness and swelling of palms or soles of feet
- •Increased liver enzymes (seen in blood tests)
- •Low blood albumin levels (seen in blood tests)
- •Protein in urine (seen in urine tests)
- •Decreased blood platelets (seen in blood tests)
- •Decreased white blood cells (seen in blood tests)
- •Indigestion, bloating, gas
- •Nosebleeds
- •Dry mouth
- •Infections
- •Unusual tiredness
- •Trouble sleeping
- •Chest pain
- •Shortness of breath
- •Leg pain
- •Swelling in legs or feet (can be signs of blood clots)
- •Heart not pumping blood effectively
- •Slow heart rate
- •Bleeding from mouth, rectum, or lungs
- •Dizziness
- •Blurred vision
- •Hot flashes
- •Swelling in face, hands, ankles, feet, or eyelids (due to fluid build-up)
- •Tingling, weakness, or numbness in hands, feet, or other limbs
- •Skin problems, redness, itching, dry skin
- •Nail problems
- •Burning, stinging, itching, or tingling sensation on the skin
- •Feeling cold, chills
- •Heavy sweating
- •Dehydration
- •Muscle, joint, tendon, or chest pain; muscle cramps
- •Hoarseness
- •Cough
- •Bloody phlegm
- •Hiccups
- •Collapsed lung (pneumothorax)
- •Underactive thyroid (detected by tests)
- •Abnormal liver function (detected by tests)
- •Increased bilirubin levels (detected by tests)
- •Increased lipase levels (detected by tests)
- •Increased creatinine levels (detected by tests)
- •Changes in other blood chemicals or enzymes (detected by tests)
RARE
- •Brain swelling (reversible posterior leukoencephalopathy syndrome)
- •Loss of speech
- •Changes in vision
- •Seizures
- •Confusion
- •Sudden, severe rise in blood pressure (hypertensive crisis)
- •Severe chest pain
- •Severe headache
- •Nausea
- •Vomiting
- •Severe anxiety
- •Fainting
- •Heart problems/heart failure/heart attack
- •Irregular or fast heartbeat
- •Rapid heart fluttering
- •Chest pain or pressure
- •Pain in arms, back, neck, or jaw
- •Swollen legs
- •Unusual heart rhythm changes (e.g., too fast or too slow heartbeat)
- •Stroke
- •Numbness or weakness on one side of the body
- •Difficulty speaking
- •Severe bleeding (in digestive system, lungs, kidneys, mouth, vagina, or brain)
- •Blood in stool or black stool
- •Blood in urine
- •Coughing or vomiting blood
- •Holes (perforation) in stomach or bowel, or abnormal connections (fistulas)
- •Fever
- •Bloody or foul-smelling pus from a wound
- •Liver problems (may lead to liver failure or damage)
- •Yellow skin or eyes
- •Dark urine
- •Tiredness
- •Loss of appetite
- •Pain in upper right side of abdomen
- •Easy bruising
- •Blood clots (deep vein thrombosis and pulmonary embolism)
- •Sharp chest pain
- •Rapid breathing
- •Swelling in arms, hands, legs, or feet
- •Blood clots in small vessels (thrombotic microangiopathy)
- •Drowsiness
- •Decreased urine output
- •Tumor lysis syndrome (fast breakdown of cancer cells)
- •Irregular heartbeat
- •Muscle cramps or spasms
- •Severe infections
- •Flu-like symptoms (cough, tiredness, body aches that don't go away)
- •Wheezing
- •Painful urination
- •Red, warm, swollen, or painful cuts or scrapes
- •Lung inflammation (pneumonitis)
- •Shortness of breath or cough that doesn't get better
- •Temporary decreased blood flow to the brain (TIA)
- •Heart attack or lack of oxygen in heart muscle (heart ischemia)
- •Increased red blood cells (detected by tests)
- •Heavy or irregular periods
- •Inflammation of the pancreas (pancreatitis)
- •Liver inflammation or damage
- •Inflammation of the lining of the abdomen (peritonitis)
- •Runny nose
- •Itchy or inflamed rash (flat, raised, or blistered)
- •Increased bowel movements
- •Increased skin sensitivity to sunlight
- •Decreased sensation on skin
- •Skin wounds that do not heal (skin ulcers)
- •Widening, weakening, or rupture of a blood vessel wall (aneurysms or arterial dissections)
Important Warnings
- Do not take Pazopanib Stada if you are allergic to pazopanib or any other ingredients in this medicine.
- Tell your doctor if you have heart, liver, kidney, or thyroid problems.
- Tell your doctor if you have had a heart attack or lung collapse.
- Tell your doctor if you have had bleeding, blood clots, or narrowed arteries.
- Tell your doctor if you have had stomach or bowel problems, like a hole or an abnormal connection (fistula).
Show 5 more warnings
- Tell your doctor if you have or have had an aneurysm (a weak spot in a blood vessel wall) or a ruptured blood vessel.
- Pazopanib Stada can raise your blood pressure. Your doctor will check your blood pressure before and during treatment. Tell your doctor if you have high blood pressure.
- If you are having surgery, your doctor will stop this medicine at least 7 days before to help your wound heal. Treatment will restart after your wound has healed.
- Do not use this medicine if you are pregnant or breastfeeding. Use reliable birth control during treatment and for at least 2 weeks after stopping. Talk to your doctor if you are planning to become pregnant or if fertility is a concern.
- This medicine may make you dizzy, tired, or weak. Do not drive or use machines if you feel this way.