Pazopanib Accord
Pazopanib Accord is a medicine that helps stop cancer cells from growing and spreading by blocking certain proteins.
Form
tabletti, kalvopäällysteinen
Strength
400 mg
Active Ingredient
Pazopanib hydrochloride
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
The usual dose is 800 mg once a day.
Method
Swallow the tablets whole with water. Do not split or crush them. Take this medicine without food, at least two hours after a meal or one hour before a meal, around the same time each day.
Important
The maximum daily dose is 800 mg once a day.
Possible Side Effects
COMMON
- •High blood pressure
- •Diarrhea
- •Feeling sick (nausea) or being sick (vomiting)
- •Stomach ache
- •Loss of appetite
- •Weight loss
- •Changes in taste or loss of taste
- •Sores in the mouth or dry mouth
- •Headache
- •Pain related to a tumor
- •Feeling tired, weak, or lacking energy
- •Changes in hair color or hair loss
- •Loss of skin color (pigment)
- •Rash, sometimes with peeling skin, redness, or itching
- •Redness and swelling of the palms of your hands or soles of your feet
- •Indigestion, bloating, or gas
- •Minor nosebleeds
- •Infections
- •Sleep problems
- •Chest pain, shortness of breath, leg pain, or swelling in legs/feet (these can be signs of a blood clot)
- •Heart not pumping blood effectively
- •Slow heartbeat
- •Moderate bleeding from the mouth, rectum, or lungs
- •Dizziness
- •Blurred vision
- •Hot flashes
- •Swelling caused by fluid retention in the face, hands, ankles, feet, or eyelids
- •Tingling, weakness, or numbness in the hands, feet, or limbs
- •Red, itchy, or dry skin, or nail problems
- •Burning, stinging, itching, or tingling sensation on the skin
- •Feeling cold or chills
- •Excessive sweating
- •Dehydration
- •Muscle pain, joint pain, tendon pain, chest pain, or muscle spasms
- •Hoarseness
- •Cough or bloody cough
- •Hiccups
- •Collapsed lung (pneumothorax), which often causes shortness of breath
- •Underactive thyroid (shown in blood tests)
- •Liver problems (shown in blood tests, less severe than liver failure)
- •Increased bilirubin, lipase, or creatinine levels (shown in blood tests)
- •Changes in other blood chemicals or enzymes (shown in blood tests)
RARE
- •Brain swelling (posterior reversible leukoencephalopathy syndrome) with symptoms like speech loss, changes in vision, seizures, confusion, or high blood pressure.
- •Hypertensive crisis (sudden and severe rise in blood pressure) with symptoms like severe chest pain, severe headache, blurred vision, confusion, nausea, vomiting, severe anxiety, shortness of breath, seizures, or fainting.
- •Heart attack (myocardial infarction) with symptoms like irregular or fast heartbeat, rapid heart palpitations, fainting, chest pain or pressure, pain in arms, back, neck or jaw, shortness of breath, or swelling of legs.
- •Heart rhythm disorder (QT prolongation).
- •Stroke with symptoms like numbness or weakness on one side of the body, difficulty speaking, headache, or dizziness.
- •Severe bleeding from the digestive system (stomach, esophagus, rectum, or bowel), kidneys, mouth, vagina, brain, or severe nosebleed, with symptoms like blood in stool (or black stool), blood in urine, abdominal pain, or bloody sputum/vomit.
- •Stomach or bowel perforation (a hole) or fistula (abnormal connection between two parts of the bowel) with symptoms like severe abdominal pain, nausea and/or vomiting, fever, or bloody/foul-smelling pus from a hole.
- •Severe liver problems (liver inflammation, liver damage, or liver failure) with symptoms like yellow skin or eyes, dark urine, fatigue, nausea, vomiting, loss of appetite, pain in the upper right abdomen, or easy bruising.
- •Pulmonary embolism (a blood clot travels to the lungs), causing sudden shortness of breath, especially with severe chest pain and/or rapid breathing.
- •Thrombotic microangiopathy (TMA), where blood clots form in small blood vessels of the kidneys and brain, and red blood cells and clotting cells decrease, with symptoms like easy bruising, high blood pressure, fever, confusion, drowsiness, seizures, or reduced urine output.
- •Tumor lysis syndrome (rapid breakdown of cancer cells) with symptoms like irregular heartbeat, seizures, confusion, muscle cramps or spasms, or reduced urine output.
- •Lung inflammation (pneumonitis) with symptoms like persistent shortness of breath or cough.
- •Retinal detachment or tear (in the back of the eye) causing blurred or reduced vision.
- •Transient ischemic attack (TIA), a temporary decrease in blood supply to the brain.
- •Myocardial ischemia, where a part of the heart receives less blood.
- •Increased red blood cells (shown in blood tests).
- •Heavy or irregular menstrual periods.
- •Pancreatitis (inflammation of the pancreas).
- •Peritonitis (inflammation of the lining of the abdomen).
- •Itchy or inflamed rash with flat, raised, or blistering spots.
- •Overactive bowel (frequent bowel movements).
- •Increased skin sensitivity to sunlight.
- •Reduced sensation, especially on the skin.
- •Non-healing skin wound (skin ulcer).
- •Aneurysm or arterial dissection (a weakening or tear in a blood vessel wall).
Important Warnings
- Do not take Pazopanib Accord if you are allergic to pazopanib or any other ingredient in this medicine.
- Tell your doctor if you have heart problems, liver problems, kidney problems, or thyroid problems.
- Tell your doctor if you have had heart failure, a heart attack, collapsed lung, bleeding, blood clots, narrowed arteries, stomach or bowel problems (like a hole or fistula), or an aneurysm (weak blood vessel).
- Your blood pressure will be checked before and during treatment, as Pazopanib Accord can increase it.
- Tell your doctor if you are going to have surgery, as this medicine might need to be stopped at least seven days before the operation.
Show 4 more warnings
- Do not drink grapefruit juice while taking Pazopanib Accord, as it can increase the risk of side effects.
- Pazopanib Accord is not recommended if you are pregnant or breastfeeding. Use reliable contraception during treatment and for at least two weeks after your last dose. Men with partners who could become pregnant should use condoms during treatment and for at least two weeks after their last dose.
- This medicine may affect fertility. Talk to your doctor if you have concerns.
- Avoid driving or using machines if you feel dizzy, tired, weak, or lack energy.