Paliperidone ratiopharm
Paliperidone ratiopharm is a long-acting medicine used to treat schizophrenia in adults and helps manage symptoms and prevent them from returning.
Form
injektioneste, depotsuspensio
Strength
150 mg + 100 mg
Active Ingredient
Paliperidone palmitate
Manufacturer
ratiopharm GmbH
How to Use
Dosage
Your doctor will give you injections. The first injection is 150 mg, and the second is 100 mg a week later, both into your upper arm. After that, you will receive 25-150 mg once a month in either your upper arm or buttock.
Method
This medicine is given as an injection into a muscle (either your upper arm or buttock) by a doctor or nurse. Do not inject into a vein or under the skin.
Important
The maximum single dose given is 150 mg, administered once a month during maintenance therapy.
Possible Side Effects
COMMON
- •Difficulty falling asleep or staying asleep.
- •Flu-like symptoms, urinary tract infection, feeling unwell.
- •Increased prolactin hormone levels in the blood, which can lead to breast swelling, erection problems, or sexual dysfunction in men, and breast discomfort, milk leakage, or missed periods in women.
- •High blood sugar, weight gain, weight loss, decreased appetite.
- •Irritability, depression, anxiety.
- •Parkinsonism, including slow or stiff movements, tremors at rest, increased drooling, and a mask-like facial expression.
- •Restlessness, drowsiness, or feeling less alert.
- •Dystonia, involving slow or prolonged involuntary muscle contractions that can affect any part of the body, often causing unusual movements in the face, eyes, mouth, tongue, or jaw.
- •Dizziness.
- •Dyskinesia, which are involuntary muscle movements that can be repetitive, spastic, twisting, or jerking.
- •Tremors.
- •Headache.
- •Fast heart rate.
- •High blood pressure.
- •Cough, stuffy nose.
- •Abdominal pain, vomiting, nausea, constipation, diarrhea, indigestion, toothache.
- •Increased liver enzyme levels in the blood.
- •Bone or muscle pain, back pain, joint pain.
- •Missed menstrual periods.
- •Fever, weakness, fatigue.
- •Reaction at the injection site, such as itching, pain, or swelling.
RARE
- •Infections like pneumonia, bronchitis, respiratory infections, bladder infections, or ear infections.
- •Allergic reaction, which can cause rash, itching, or swelling.
- •New or worsening diabetes.
- •Fainting or feeling dizzy when standing up quickly.
- •Problems with your heart rhythm or changes in your heart's electrical activity (seen on an EKG).
- •Low blood pressure, especially when you stand up.
- •Swelling of the face, mouth, eyes, lips, or other body parts like arms and legs.
- •Confusion, sleepwalking, or lack of emotions.
- •Stroke or mini-stroke symptoms, such as sudden weakness or trouble speaking.
- •Seizures.
- •Eye problems, like glaucoma (high pressure in the eye) or difficulty moving your eyes.
- •Blood clots in the lungs or legs, causing chest pain, breathing difficulty, or leg swelling and pain.
- •Pancreatitis (inflammation of the pancreas), swollen tongue, or problems controlling bowel movements.
- •Muscle breakdown (rhabdomyolysis) or muscle pain.
- •Very low body temperature, chills, or feeling very thirsty.
- •Skin problems at the injection site, like an abscess (pus pocket), deep skin infection, or a bruise.
Important Warnings
- Seek immediate medical attention if you experience a blood clot, especially in the legs (swelling, pain, redness), as it can travel to the lungs, causing chest pain and breathing difficulties.
- Contact your doctor if you have dementia and experience sudden changes in mental state, or sudden weakness or numbness in your face, arms, or legs (especially on one side), or slurred speech, as these can be signs of a stroke.
- Get immediate medical help if you have a fever, muscle stiffness, sweating, or decreased consciousness, which are signs of a serious condition called neuroleptic malignant syndrome.
- If you are a man and experience a prolonged or painful erection, known as priapism, seek immediate medical attention.
- Inform your doctor if you have rhythmic, involuntary movements of your tongue, mouth, or face, as your paliperidone treatment may need to be stopped.
Show 3 more warnings
- Seek urgent medical help if you experience a severe allergic reaction, with symptoms like fever, swelling of the mouth, face, lips, or tongue, shortness of breath, itching, rash, and sometimes low blood pressure.
- If you have an eye surgery planned, tell your eye doctor that you are using this medicine, as it can cause problems during cataract surgery (floppy iris syndrome).
- Inform your doctor if you have dangerously low levels of certain white blood cells needed to fight infections.