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Paliperidone ratiopharm

Paliperidone ratiopharm is an antipsychotic medicine used for the long-term treatment of schizophrenia in adults to relieve symptoms and prevent them from returning.

Form
injektioneste, depotsuspensio
Strength
100 mg
Active Ingredient
Paliperidone palmitate
Manufacturer
ratiopharm GmbH

How to Use

Dosage

The first injection (150 mg) and the second (100 mg) are given in the upper arm about one week apart. After that, injections (25–150 mg) are given once a month in the upper arm or buttock.

Method

Your doctor or nurse will give you the injection deep into a muscle, either in your upper arm or buttock.

Important

Your doctor will decide the maximum dose you receive for each injection, usually 25–150 mg once a month.

Possible Side Effects

COMMON
  • •Difficulty falling asleep or interrupted sleep.
  • •Flu-like symptoms, urinary tract infection, feeling feverish.
  • •High prolactin hormone levels in the blood, which can cause breast swelling or erection problems in men, and breast discomfort, milk leakage, or missed periods in women.
  • •High blood sugar, weight gain, weight loss, decreased appetite.
  • •Irritability, depression, anxiety.
  • •Parkinsonism-like symptoms, such as slow movements, muscle stiffness, tremor, and a lack of facial expression.
  • •Restlessness, drowsiness, or decreased alertness.
  • •Dystonia, such as involuntary muscle twitching or contractions, especially in the face, eyes, mouth, tongue, or jaw.
  • •Dizziness.
  • •Involuntary muscle movements (dyskinesia).
  • •Tremor.
  • •Headache.
  • •Fast heart rate.
  • •High blood pressure.
  • •Cough, stuffy nose.
  • •Stomach pain, vomiting, nausea, constipation, diarrhea, indigestion, toothache.
  • •High liver enzyme levels in blood.
  • •Muscle or bone pain, back pain, joint pain.
  • •Missed periods.
  • •Fever, weakness, fatigue.
  • •Injection site reaction, such as itching, pain, or swelling.
RARE
  • •Pneumonia, bronchitis, respiratory infection, bladder infection, ear infection.
  • •Decreased white blood cells or anemia.
  • •Allergic reaction.
  • •New onset or worsening diabetes, high insulin levels.
  • •Increased appetite.
  • •Loss of appetite, malnutrition and weight loss.
  • •High triglyceride or cholesterol levels in blood.
  • •Sleep disturbances, mania, decreased libido, nervousness, nightmares.
  • •Tardive dyskinesia (involuntary, jerky movements of the face, tongue, or other body parts).
  • •Fainting, restless legs, dizziness when standing up, concentration problems, speech difficulties, taste disorders, sensory disturbances, tingling or numbness.
  • •Blurred vision, eye inflammation, red eyes, dry eyes.
  • •Vertigo, ringing in the ears, ear pain.
  • •Heart rhythm disorders, changes in ECG, fast or slow heart rate, palpitations.
  • •Low blood pressure, dizziness or fainting when standing up.
  • •Shortness of breath, sore throat, nosebleed.
  • •Abdominal discomfort, stomach or intestinal inflammation, difficulty swallowing, dry mouth, excessive gas.
  • •High liver enzyme levels (GGT).
  • •Hives, itching, rash, hair loss, dry skin, skin redness, acne, skin abscesses.
  • •High creatine phosphokinase (CPK) in blood.
  • •Muscle cramps, joint stiffness, muscle weakness.
  • •Urinary incontinence, frequent urination, painful urination.
  • •Erectile dysfunction, ejaculation disorders, menstrual cycle disorders (in women), breast development in men, sexual dysfunction, breast pain, milk discharge from breasts.
  • •Swelling of face, mouth, eyes, lips, body, arms, or legs.
  • •Increased body temperature.
  • •Changes in walking.
  • •Chest pain, chest discomfort, malaise.
  • •Hardening of skin.
  • •Falls.
  • •Eye infection.
  • •Mite-induced skin inflammation, flaky and itchy scalp or skin.
  • •Increased eosinophils (a type of white blood cell) in blood.
  • •Decreased platelet count.
  • •Head tremor.
  • •Abnormal secretion of hormone regulating urine volume.
  • •Sugar in urine.
  • •Life-threatening complications of uncontrolled diabetes.
  • •Low blood sugar.
  • •Excessive water intake.
  • •Immobility and unresponsiveness while awake (catatonia).
  • •Confusion.
  • •Sleepwalking.
  • •Lack of emotions.
  • •Inability to have an orgasm.
  • •Neuroleptic malignant syndrome, stroke, seizures, balance disorders.
  • •Coordination problems.
  • •Glaucoma.
  • •Eye movement disorders, eye rolling, light sensitivity, increased tear production, red eyes.
  • •Atrial fibrillation or other heart rhythm disorders.
  • •Pulmonary embolism causing chest pain and breathing difficulties.
  • •Blood clots, especially in legs (swelling, pain, redness).
  • •Redness in face and neck.
  • •Sleep apnea (breathing problems during sleep).
  • •Congestion in lungs and airways.
  • •Wheezing or rattling breathing.
  • •Pancreatitis, tongue swelling, fecal incontinence, severe constipation.
  • •Bowel obstruction.
  • •Chapped lips.
  • •Drug rash, skin thickening, dandruff.
  • •Muscle breakdown (rhabdomyolysis) and muscle pain.
  • •Joint swelling.
  • •Urinary retention.
  • •Breast discomfort, glandular enlargement, breast enlargement.
  • •Vaginal discharge.
  • •Priapism (prolonged erection).
  • •Very low body temperature, chills, thirst.
  • •Drug withdrawal symptoms.
  • •Injection site abscess, deep skin infection, cyst or bruise.
  • •Dangerously low levels of white blood cells needed to fight infection.
  • •Sleep-related eating disorder.
  • •Coma due to uncontrolled diabetes.
  • •Reduced oxygen supply to parts of the body (due to reduced blood flow).
  • •Rapid shallow breathing, pneumonia from inhaling food, voice disorders.
  • •Lack of bowel muscle movement (bowel obstruction).
  • •Yellowing of skin and eyes (jaundice).
  • •Severe, life-threatening skin rashes with blistering and peeling (Stevens-Johnson syndrome).

Important Warnings

  • Do not use if you are allergic to paliperidone or risperidone.
  • Seek immediate medical attention if you experience symptoms of a blood clot, such as swelling, pain, or redness in your leg, chest pain, or difficulty breathing.
  • Tell your doctor if you have dementia and experience sudden confusion, weakness or numbness in your face, arms, or legs, or speech problems, as these could be signs of a stroke.
  • Seek immediate medical attention if you have a fever, muscle stiffness, sweating, or decreased consciousness (called neuroleptic malignant syndrome).
  • Tell your doctor if you have involuntary rhythmic movements of your tongue, mouth, or face. Your medication may need to be stopped.
Show 6 more warnings
  • Seek immediate medical attention if you are a man and experience a prolonged or painful erection.
  • Contact your doctor immediately if you experience severe allergic symptoms such as fever, swelling of the mouth, face, lips, or tongue, difficulty breathing, itching, or rash.
  • Tell your eye doctor if you are planning eye surgery and are taking this medicine, as it may affect the surgery.
  • Tell your doctor if you know you have dangerously low levels of white blood cells that fight infections.
  • Do not use this medicine during pregnancy or breastfeeding without discussing it with your doctor.
  • This medicine may cause dizziness, drowsiness, or vision problems, so be careful when driving or operating machinery.

Additional Information

ATC Code: N05AX13
→ View Professional Information (PDF)→ View Patient Leaflet (PDF)