Paliperidone ratiopharm
Paliperidone ratiopharm is a medicine that helps manage the symptoms of schizophrenia in adults and prevents them from returning.
Form
injektioneste, depotsuspensio
Strength
50 mg
Active Ingredient
Paliperidone palmitate
Manufacturer
ratiopharm GmbH
How to Use
Dosage
The first injection is 150 mg, the second is 100 mg about one week later, followed by 25-150 mg once a month.
Method
Given as an injection into a muscle (upper arm or buttocks).
Important
The monthly dose can range from 25 mg to 150 mg, as decided by your doctor.
Possible Side Effects
COMMON
- •Trouble sleeping or interrupted sleep.
- •Flu-like symptoms or urinary tract infection.
- •Increased levels of a hormone called prolactin in the blood (can cause breast swelling, erection problems in men, breast discomfort, milk leakage, missed periods in women).
- •High blood sugar, weight gain or loss, decreased appetite.
- •Irritability, depression, anxiety.
- •Parkinson-like symptoms (slow movement, stiff muscles, shaking, increased saliva, flat facial expression).
- •Restlessness, drowsiness or feeling less alert, dizziness.
- •Dystonia (uncontrolled muscle spasms, can affect face, eyes, mouth, tongue, or jaw).
- •Dyskinesia (uncontrolled muscle movements, jerky or twisting).
- •Shaking (tremor) or headache.
- •Fast heartbeat or high blood pressure.
- •Cough or stuffy nose.
- •Stomach ache, vomiting, nausea, constipation, diarrhea, indigestion, toothache.
- •Increased liver enzymes in blood.
- •Bone, muscle, back, or joint pain.
- •Missed menstrual periods.
- •Fever, weakness, or tiredness.
- •Injection site reactions (itching, pain, swelling).
RARE
- •Lung infection (pneumonia, bronchitis), airway infection, sinus infection, bladder infection, ear infection, nail fungal infection, tonsil infection, skin infection.
- •Low white blood cell count (which fight infections), anemia, allergic reaction.
- •New or worsening diabetes, increased insulin in blood.
- •Increased appetite, loss of appetite leading to malnutrition and low body weight.
- •High fat levels (triglycerides, cholesterol) in blood.
- •Sleep problems, high mood (mania), reduced sex drive, nervousness, nightmares.
- •Tardive dyskinesia (uncontrolled, jerky movements of the face, tongue, or other body parts).
- •Fainting, strong urge to move a body part, dizziness when standing up.
- •Trouble concentrating, speech problems, loss/change of taste, reduced sensation of pain/touch on skin, tingling, pricking, or numbness in skin.
- •Blurred vision, eye infection, red eyes, dry eyes.
- •Spinning sensation (vertigo), ringing in ears, ear pain.
- •Changes in heart rhythm (slow or fast heartbeat, abnormal EKG, fluttering in chest).
- •Low blood pressure, low blood pressure when standing up (can cause weakness, dizziness, fainting).
- •Shortness of breath, sore throat, nosebleed.
- •Stomach discomfort, stomach or gut infection, difficulty swallowing, dry mouth, lots of gas.
- •Increased liver enzyme GGT in blood.
- •Hives, itching, rash, hair loss, eczema, dry skin, red skin, acne, pus under the skin.
- •Increased muscle enzyme (creatine phosphokinase) in blood.
- •Muscle cramps, stiff joints, muscle weakness.
- •Urinary incontinence, frequent urination, painful urination, inability to urinate.
- •Erectile dysfunction, ejaculation problems, missed or irregular periods (in women), breast development in men, sexual dysfunction, breast pain, milk discharge from breasts.
- •Swelling of face, mouth, eyes, or lips; swelling of body, arms, or legs.
- •Increased body temperature, changes in walking, chest pain/discomfort, feeling unwell, hardening of the skin, falls.
- •Skin inflammation caused by mites, scaly and itchy scalp or skin, eye infection.
- •Increased eosinophils (a type of white blood cell) in blood, decreased platelets (cells that help stop bleeding) in blood.
- •Head shaking, abnormal secretion of a hormone that controls urine volume, sugar in urine.
- •Life-threatening complications of uncontrolled diabetes, low blood sugar, drinking too much water.
- •Being motionless and unresponsive while awake (catatonia), confusion, sleepwalking, lack of emotions, inability to have an orgasm.
- •Neuroleptic malignant syndrome (confusion, reduced consciousness or unconsciousness, high fever, severe muscle stiffness).
- •Brain blood vessel problems, including stroke or mini-stroke, not responding to stimuli, loss of consciousness, reduced awareness, seizures, balance problems.
- •Abnormal coordination, glaucoma (high pressure in the eye).
- •Eye movement problems, rolling eyes, sensitivity to light, increased tearing, red eyes.
- •Atrial fibrillation (a type of irregular heartbeat), irregular heartbeat, blood clot in the lungs (causing chest pain and trouble breathing).
- •Blood clot in leg veins (swelling, pain, redness in leg), redness in the face and neck.
- •Breathing problems during sleep (sleep apnea), lung congestion, airway congestion, wheezing, noisy breathing.
- •Pancreatitis (inflammation of the pancreas), swelling of the tongue, fecal incontinence, severe constipation, bowel obstruction, chapped lips.
- •Drug rash, skin thickening, dandruff, muscle breakdown and muscle pain (rhabdomyolysis), joint swelling.
- •Breast discomfort, breast gland enlargement, breast enlargement, vaginal discharge.
- •Priapism (prolonged erection that may need surgery), very low body temperature, chills, thirst, drug withdrawal symptoms.
- •Abscess, deep skin infection, cyst, or bruise at injection site.
- •Sleep-related eating disorder, coma.
- •Lack of oxygen in some body parts, fast, shallow breathing, pneumonia from inhaling food, voice problems.
- •Stoppage of bowel movements (causing obstruction), yellowing of skin and eyes (jaundice).
- •Severe or life-threatening skin rash with blisters and peeling skin (Stevens-Johnson syndrome, toxic epidermal necrolysis).
- •Lower body temperature (in newborns), drug withdrawal symptoms in newborns (irritability, stiff muscles, shaking, drowsiness, breathing or eating problems), skin cell death at injection site, injection site ulcers.
Important Warnings
- Seek immediate medical help if you get a blood clot (swelling, pain, redness in leg, chest pain, breathing difficulty).
- If you have dementia and suddenly change mentally, or have weakness/numbness in your face, arm, or leg, or slurred speech, these could be signs of a stroke.
- Get urgent medical care if you have fever, stiff muscles, sweating, or confusion.
- If you are a man and have an erection that is long-lasting or painful, seek immediate medical attention.
- Tell your doctor if you have uncontrolled twitching movements of your tongue, mouth, or face; your doctor might need to stop this medicine.
Show 3 more warnings
- Seek immediate medical help if you have a severe allergic reaction (fever, swelling of mouth/face/lips/tongue, trouble breathing, itching, rash, low blood pressure).
- If you are planning eye surgery, tell your eye doctor about this medicine, as it can affect your iris.
- Contact your doctor if you have dangerously low levels of certain white blood cells needed to fight infections.