Paclitaxel Fresenius Kabi
Paclitaxel Fresenius Kabi is a cancer medicine that stops cancer cells from growing.
Form
infuusiokonsentraatti, liuosta varten
Strength
6 mg/ml
Active Ingredient
Paclitaxel
Manufacturer
Fresenius Kabi AB
How to Use
Dosage
Your doctor will decide your dose based on blood tests, type of cancer, and how serious it is.
Method
This medicine is given as a drip into a vein (intravenous infusion) over 3 or 24 hours. It is usually given every 2 or 3 weeks.
Important
The maximum daily dose is determined by your doctor based on your treatment plan and infusion schedule.
Possible Side Effects
COMMON
- •Mild allergic reactions like flushing, rash, or itching.
- •Infections, mainly upper respiratory or urinary tract infections.
- •Sore throat, mouth sores, red and painful mouth, diarrhea, nausea, or vomiting.
- •Hair loss (often severe and starting within a month of treatment).
- •Muscle pain, cramps, joint pain.
- •Numbness, tingling, or weakness in arms and legs (signs of nerve damage), which can last over 6 months after treatment.
- •Blood tests may show low platelet count (can cause bleeding/bruising), low red or white blood cell count, and low blood pressure.
RARE
- •Minor changes in nails and skin, reactions at injection site (swelling, pain, redness).
- •Slowed heart rate, high liver enzyme levels (seen in blood tests).
- •Shock due to infection (septic shock).
- •Palpitations, serious heart problems (like blockages or muscle disease), fast heart rate, heart attack, breathing difficulties.
- •Fatigue, sweating, fainting, severe allergic reactions, vein inflammation (phlebitis), swelling of face, lips, mouth, tongue, or throat.
- •Back pain, chest pain, pain in hands and feet, chills, stomach pain.
- •Blood tests may show high bilirubin (jaundice), high blood pressure, blood clots.
- •Low white blood cell count with fever and increased infection risk (febrile neutropenia).
- •Nerve effects with muscle weakness in arms and legs (motor neuropathy).
- •Heart failure.
- •Shortness of breath, pulmonary embolism, lung fibrosis, interstitial pneumonia, fluid buildup in the lungs.
- •Bowel obstruction, bowel perforation, colon inflammation (ischemic colitis), pancreatitis.
- •Itching, rash, skin redness (erythema).
- •Blood poisoning (sepsis), peritonitis, pneumonia.
- •Fever, dehydration, weakness, swelling, general unwell feeling.
- •Severe, possibly life-threatening allergic reaction (anaphylaxis).
- •Blood tests may show increased creatinine, a sign of kidney problems.
- •Irregular, fast heart rhythm (atrial fibrillation, supraventricular tachycardia).
- •Sudden disorder of blood-forming cells (acute myeloid leukemia, myelodysplastic syndrome).
- •Optic nerve problems and/or vision problems.
- •Hearing loss or impairment (ototoxicity), ringing in ears (tinnitus), vertigo.
- •Cough.
- •Blood clot in abdominal or intestinal blood vessels (mesenteric thrombosis), colon inflammation sometimes with persistent severe diarrhea (pseudomembranous colitis, neutropenic colitis), fluid accumulation in the abdomen (ascites), esophagitis, constipation.
- •Severe hypersensitivity reactions including fever, skin redness, joint pain, eye inflammation (Stevens-Johnson syndrome), skin peeling (epidermal necrolysis), irregular red patches (erythema multiforme), skin inflammation with blisters and shedding (exfoliative dermatitis), hives, nail detachment.
- •Loss of appetite (anorexia).
- •Severe, potentially fatal hypersensitivity reactions with shock (anaphylactic shock).
- •Liver dysfunction (hepatic necrosis, hepatic encephalopathy), some cases fatal.
- •Confusion.
- •Seizures (Grand mal), nerve disorder (autonomic neuropathy which can cause bowel paralysis and low blood pressure), cramps, brain disease (encephalopathy), dizziness, headache, coordination problems (ataxia).
- •Rapid breakdown of tumor cells (tumor lysis syndrome).
- •Fluid buildup in the eye (macular edema), seeing light flashes (photopsia), floaters in vision.
- •Vein inflammation (phlebitis).
- •Thickening and hardening of skin, blood vessels, and internal organs (scleroderma).
- •'Butterfly rash' (Systemic Lupus Erythematosus - SLE), an immune system disease affecting many organs.
- •Blood clotting disorders (Disseminated Intravascular Coagulation or 'DIC'), a serious condition causing easy bleeding, easy clotting, or both.
- •Redness and swelling on palms or soles, which may cause skin peeling.
Important Warnings
- Tell your doctor right away if you have allergic reactions like trouble breathing, chest tightness, low blood pressure, dizziness, weakness, or skin rash.
- Tell your doctor right away if you have fever, severe chills, sore throat, or mouth sores, as these can be signs of bone marrow problems.
- Tell your doctor right away if you have numbness, tingling, prickling, increased sensitivity to touch, or weakness in your arms and legs. Your dose might need to be lowered.
- Tell your doctor right away if you get severe or long-lasting diarrhea with fever and stomach pain during or soon after treatment.
- This medicine is not recommended if you have severe liver problems.
Show 3 more warnings
- Tell your doctor if you have heart problems or conduction disorders.
- Tell your doctor if you have received radiation therapy to your chest area, as this can increase the risk of lung inflammation.
- If you have Kaposi's sarcoma and have a sore or red mouth (signs of mucositis), you might need a lower dose.