Oxyratio Depot
Oxyratio Depot is a strong pain medicine (opioid) used for severe pain in adults and children 12 years and older when other pain medicines are not enough.
How to Use
Dosage
Usually, take 10 mg every 12 hours. Your doctor might start you on 5 mg to lessen side effects.
Method
Swallow the tablets whole or halved with half a glass of water, in the morning and evening at fixed times (e.g., 8 AM and 8 PM). You can take them with or without food. Do not chew or crush them, as this can release too much medicine at once and be dangerous.
For non-cancer pain, the usual maximum is 40 mg per day, though higher doses may be needed. For cancer pain, doses typically range from 80-120 mg, and can go up to 400 mg in some cases, as directed by your doctor.
Possible Side Effects
- •Drowsiness (feeling very sleepy), dizziness, headache
- •Constipation, nausea (feeling sick), vomiting (being sick)
- •Itching
- •Decreased or no appetite
- •Anxiety, confusion, depression, decreased activity, restlessness, increased activity, nervousness, sleep problems, unusual thoughts
- •Tremor (shaking), extreme tiredness
- •Shortness of breath
- •Stomach pain, diarrhea, dry mouth, hiccups, indigestion
- •Skin reactions like rash, increased sweating, increased sensitivity to light (rarely), or flaking skin rash (in isolated cases)
- •Pain or sudden urge when urinating
- •Weakness, fatigue
- •Problems with hormones or fluid balance (e.g., abnormal ADH secretion, dehydration)
- •Agitation, mood swings, feeling extremely happy, seeing or hearing things that aren't there (hallucinations)
- •Decreased sex drive, drug dependence
- •Unusual muscle stiffness, muscle spasms, seizures (fits), decreased pain or touch sensation, speech problems, fainting, tingling, coordination problems, changes in taste, memory loss, concentration problems, migraine
- •Changes in tear production, vision problems, very sensitive hearing, hearing loss, spinning sensation (vertigo)
- •Increased heart rate, irregular or strong heartbeat (palpitations), widened blood vessels
- •Voice changes, cough, sore throat, runny nose
- •Mouth sores, gum inflammation, stomatitis (mouth swelling), difficulty swallowing, gas, burping, bowel blockage
- •Increased liver enzymes, dry skin, problems with urinating (urinary retention)
- •Impotence, decreased sex hormone levels
- •Chills, pain (e.g., chest pain), general feeling of being unwell, thirst, swelling in hands, ankles, or feet (fluid retention)
- •Withdrawal symptoms (like yawning, sweating, anxiety, muscle pain, tremors) if you stop taking the medicine suddenly, tolerance (needing higher doses for the same pain relief), accidental injuries
- •Herpes simplex (cold sores or skin rash), lymph node disease (swollen glands), increased appetite
- •Low blood pressure with dizziness when standing up
- •Black, tarry stools, dental problems, bleeding gums
- •Hives (itchy rash), blood in urine, weight changes (gain or loss), cellulitis (skin infection)
- •Aggression, increased pain sensitivity that doesn't get better with higher doses, sleep apnea (breathing stops during sleep)
- •Tooth decay, right-sided stomach pain, gallstone colic (severe pain from gallstones), problems with a muscle in the intestines (Oddi's sphincter dysfunction) causing severe upper stomach pain
- •No menstruation (amenorrhea)
- •Newborn withdrawal syndrome (irritability, hyperactivity, abnormal sleep, high-pitched crying, tremors, vomiting, diarrhea, failure to gain weight) if used long-term during pregnancy.
Important Warnings
- Do not use if you are allergic to oxycodone or any other ingredient in this medicine.
- Do not use if you have severe breathing problems (like very low oxygen or high carbon dioxide in your blood, severe lung diseases like COPD or asthma, or heart problems due to long-term lung disease).
- Do not use if your bowels have stopped working (paralytic ileus), if you have acute stomach pain, or if your stomach empties very slowly.
- If you have not taken opioid medicines before, do not start with 80 mg tablets. Their strong dose can cause dangerous shallow and slow breathing.
- This medicine is an opioid and can lead to dependence or addiction.
Show 4 more warnings
- Only swallow the tablets. Injecting them can cause serious, even deadly, harm to your body's tissues and organs.
- Do not use if you are pregnant or breastfeeding.
- This medicine can make you drowsy and affect your ability to drive or use machines.
- Avoid alcohol and grapefruit juice while taking this medicine, as they can increase serious side effects and be dangerous.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)