Oxycodone/Naloxone Krka
Oxycodone/Naloxone Krka is a medicine used to treat severe pain or severe restless legs syndrome, and it also helps prevent constipation.
How to Use
Dosage
For pain: 10 mg oxycodone / 5 mg naloxone every 12 hours. For restless legs: 5 mg oxycodone / 2.5 mg naloxone every 12 hours. Your doctor will adjust the dose for you.
Method
Swallow the tablets whole with enough liquid, such as half a glass of water. You can take them with or without food, every 12 hours at the same time each day (e.g., 8 AM and 8 PM). Do not break, chew, or crush them.
For pain: Max 160 mg oxycodone / 80 mg naloxone per day. For restless legs: Max 60 mg oxycodone / 30 mg naloxone per day.
Possible Side Effects
- •Stomach upset (including pain, constipation, diarrhea, dry mouth, indigestion, nausea, vomiting, gas)
- •Decreased appetite
- •Dizziness
- •Headache
- •Hot flashes
- •Unusual weakness or tiredness
- •Itching
- •Rash
- •Sweating
- •Sleep problems
- •Drowsiness
- •Swollen abdomen
- •Mood and emotional changes (such as anxiety, confusion, depression, nervousness, strong feeling of happiness or aggression)
- •Chest pain
- •Changes in blood pressure (low or high)
- •Withdrawal symptoms (e.g., agitation)
- •Fainting
- •Thirst
- •Changes in taste
- •Palpitations
- •Gallstone attack
- •General feeling of unwellness
- •Swelling (in hands and feet)
- •Difficulty concentrating
- •Speech problems
- •Tremors
- •Breathing difficulties (including shallow breathing and sleep apnea)
- •Restlessness
- •Chills
- •Increased liver function values
- •Decreased sex drive
- •Runny nose
- •Cough
- •Allergic reactions
- •Weight changes
- •Frequent urination or difficulty urinating
- •Muscle cramps, pain, or twitching
- •Vision problems
- •Seizures
- •Rapid heart rate
- •Drug dependence
- •Yawning
- •Severe drowsiness
- •Erectile dysfunction
- •Nightmares
- •Hallucinations
- •Skin tingling
- •Belching
- •Dental problems (tooth changes)
Important Warnings
- Do not use if allergic to any ingredients.
- Do not use if you have severe breathing problems (e.g., severe asthma, COPD, or very slow breathing).
- Do not use if you have severe liver or kidney problems.
- Do not use if you have a blocked bowel not caused by opioids.
- Tell your doctor if you have heart conditions, low or high blood pressure, or a head injury.
Show 9 more warnings
- Tell your doctor if you have problems with your thyroid, adrenal glands, pancreas, or gallbladder.
- Tell your doctor if you have epilepsy or have had seizures.
- Do not break, chew, or crush the tablets; swallow them whole.
- This medicine can cause addiction; tell your doctor if you have a history of drug or alcohol abuse.
- Avoid alcohol and grapefruit juice while taking this medicine.
- This medicine is not for children under 18 years old.
- Do not use during pregnancy or breastfeeding without consulting your doctor.
- Do not drive or operate machinery if you feel drowsy or fall asleep suddenly.
- Using this medicine with certain antidepressants or sedatives can cause serious side effects, including severe drowsiness or breathing problems. Tell your doctor about all other medicines you take.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. Reduce the dose already in mild renal impairment. Increases the risk of confusion and falling. Need for laxative is often necessary. Consider potential interactions. Avoid grapefruit. (updated 24.3.2025)