Ondansetron Hameln

This medicine helps prevent and treat nausea and vomiting caused by cancer treatment (chemotherapy or radiation) or surgery.

Form
injektioneste, liuos
Strength
2 mg/ml
Active Ingredient
Ondansetron hydrochloride dihydrate
Manufacturer
Hameln Pharma GmbH

How to Use

Dosage

Your doctor will decide your dose based on your treatment. For cancer treatment, adults typically receive 8-32 mg daily, and for surgery, usually 4 mg as a single dose. For children, the doctor will determine the dose, typically 4 mg for cancer treatment or a maximum of 4 mg for surgery. Patients with liver problems should not exceed 8 mg per day.

Method

This medicine is given as an injection into a vein or as a slow infusion (drip) into a vein after it has been diluted. A doctor or nurse will usually give you this medicine.

Important

The maximum daily dose for adults is 32 mg.

Possible Side Effects

COMMON
  • Headache
  • Flushing and feeling warm
  • Constipation
  • Local reaction at the injection site
RARE
  • Chest pain, irregular or slow heartbeat
  • Involuntary movements (like jerky eye movements or muscle spasms), and seizures
  • Low blood pressure
  • Hiccups
  • Increase in liver enzyme levels (usually without symptoms)
  • Allergic reactions at the injection site (like rash, hives, itching)
  • Severe allergic reactions (e.g., swelling of the face, lips, throat, difficulty breathing, rash, itching)
  • Temporary changes in heart rhythm (seen on an ECG)
  • Dizziness (with rapid administration)
  • Temporary vision changes (with rapid administration)
  • Depression
  • Temporary blindness
  • Heart muscle ischemia (chest pain or tightness)

Important Warnings

  • Do not use if you are allergic to ondansetron, similar medicines (like granisetron or dolasetron), or any other ingredient in this medicine.
  • Do not use if you are taking apomorphine (a medicine for Parkinson's disease).
  • Tell your doctor if you have a bowel blockage or severe constipation, as this medicine can worsen it.
  • Inform your doctor if you have heart problems (like heart failure or an irregular heartbeat).
  • Tell your doctor if you are going to have tonsil surgery.
Show 3 more warnings
  • Inform your doctor if you have liver problems or problems with your blood salt levels (like potassium, sodium, magnesium).
  • This medicine should not be used during the first three months of pregnancy, and women who can become pregnant should use effective birth control.
  • Do not breastfeed while taking this medicine, as it passes into breast milk.

Use in Elderly Patients

Category C

Suitable for older adults, with specific cautions. May prolong the QT interval especially with other preparations prolonging QT. Take interactions into account. (updated 20.5.2024)