Normosang
Normosang is a medicine used to treat sudden attacks of acute hepatic porphyria, a rare liver disease.
Form
infuusiokonsentraatti, liuosta varten
Strength
25 mg/ml
Active Ingredient
Human hemin
Manufacturer
Recordati Rare Diseases
How to Use
Dosage
The dose is calculated based on your body weight, approximately 3 mg per kg of body weight per day.
Method
The medicine is given as an infusion into a large vein in your arm or chest for at least 30 minutes. The vein is then flushed with saline solution.
Important
The maximum dose is 250 mg (one ampoule) per day.
Possible Side Effects
COMMON
- •Difficulty accessing veins after repeated treatments.
- •Pain and inflammation at the injection site if the medicine is given into a vein that is too small.
RARE
- •Fever
- •Severe allergic reactions, such as rash and swollen tongue.
- •Anaphylactoid reaction (a sudden, potentially life-threatening allergic reaction)
- •Increased iron levels in the blood after long-term use.
- •Headache
- •Venous thrombosis (blood clots in veins), including at the injection site.
- •Leakage of infusion fluid into surrounding tissue (extravasation).
- •Skin damage (necrosis).
- •Redness of the skin at the injection site.
- •Itching of the skin at the injection site.
- •Increased creatinine levels in the blood.
- •Skin discoloration.
Important Warnings
- Do not use Normosang if you are allergic to human hemin or any other ingredient in this medicine.
- Avoid sudden changes in your diet, especially long periods without eating.
- Do not use medicines or substances like estrogens (e.g., birth control pills), barbiturates, or steroids, as they can trigger or worsen an attack.
- A blood clot (venous thrombosis) can block the vein used for the infusion.
- If the needle stays in place for too long, the vein can be damaged, causing Normosang to leak outside the vein (extravasation), which may discolour the skin.
Show 2 more warnings
- To limit the risk of increased iron levels, Normosang should not be used as a preventive treatment for acute attacks.
- Medicines made from human blood or plasma carry a small risk of transmitting infections, even with safety measures in place.