Nitisinone Dipharma
Nitisinone Dipharma is a medicine that helps your body process a substance called tyrosine. It stops harmful substances from building up in your body due to rare diseases like tyrosinemia type 1 and alkaptonuria.
How to Use
Dosage
For tyrosinemia type 1: Your doctor will decide your exact dose, usually 1 mg per kilogram of body weight per day. For AKU: Usually 10 mg once a day.
Method
Take the capsules usually once a day. If you weigh less than 20 kg, you might take your dose in two parts. If swallowing is hard, you can open the capsule and mix the contents with water or soft food. Always take with food if you started the treatment with food.
The typical maximum dose is 1 mg per kilogram of body weight per day for tyrosinemia type 1, and 10 mg per day for AKU. Your doctor may adjust this.
Possible Side Effects
- •Eye problems (such as inflammation, clouding, pain, and sensitivity to light)
- •Lower numbers of blood cells, including platelets and certain white blood cells
- •Bronchitis (inflammation of the airways)
- •Pneumonia (lung infection)
- •Itching and skin rash
- •Eyelid inflammation (blepharitis)
- •Higher number of white blood cells
- •Skin inflammation (dermatitis)
Important Warnings
- Do not use if you are allergic to nitisinone or any other ingredients in this medicine.
- Do not breastfeed while taking this medicine.
- Your eyes will be checked before starting treatment and regularly during it. If you have eye problems, such as redness, contact your doctor right away. This could mean your diet is not correct.
- You will have blood tests during treatment to make sure the medicine is working and not causing side effects with your blood.
- If you take this medicine for hereditary tyrosinemia type 1, your liver will be checked regularly because the disease affects the liver.
Show 3 more warnings
- Talk to your doctor if you are pregnant, planning to get pregnant, or breastfeeding. This medicine has not been studied in pregnant or breastfeeding women.
- This medicine can affect your ability to drive or use machines. If your vision is blurry, do not drive or use machines until your vision is normal.
- Tell your doctor about all other medicines you are taking, as Nitisinone Dipharma can affect their effectiveness, for example, epilepsy medicines or blood thinners.