Mitoxantron Ebewe
Mitoxantron Ebewe is a cancer medicine that stops cancer cells from growing and is also used to treat a specific type of multiple sclerosis.
Form
infuusiokonsentraatti, liuosta varten
Strength
2 mg/ml
Active Ingredient
Mitoxantrone hydrochloride
Manufacturer
Ebewe Pharma Ges.m.b.H. Nfg.KG
How to Use
Dosage
Your doctor will decide your dose based on your body surface area; doses typically range from 5–14 mg per square meter, given as a single dose or daily for a few days, depending on your condition.
Method
The medicine is always given as a diluted, slow drip into a vein (intravenous infusion) under a doctor's supervision.
Important
The maximum dose typically given on a single day is 14 mg per square meter.
Possible Side Effects
COMMON
- •Infections
- •Low red blood cells (anemia), tiredness, shortness of breath
- •Low white blood cells (neutrophils, leukocytes, granulocytes)
- •Nausea
- •Vomiting
- •Hair loss
- •Low platelet count, bleeding, bruising
- •Weakness, lack of energy
- •Loss of appetite
- •Constipation
- •Diarrhea
- •Mouth and lip inflammation
- •Fever
- •Congestive heart failure
- •Abnormal white blood cell count
- •Headache
- •Irregular heartbeat
- •Abnormal EKG
- •Decreased heart pumping ability without symptoms
- •Abnormal liver function tests
- •Abnormal absence of menstruation
- •Heart attack
- •Shortness of breath
RARE
- •Bone marrow depression
- •Bone marrow failure (insufficient blood cell production)
- •Severe allergic reaction (anaphylaxis), including hives, swelling (hands, feet, ankles, face, lips, mouth/throat), difficulty swallowing/breathing, dizziness
- •Upper respiratory infections
- •Urinary tract infections
- •Sepsis (blood poisoning)
- •Opportunistic infections (infections by microorganisms normally not causing disease in healthy immune system)
- •White blood cell cancer (acute myeloid leukemia)
- •Bone marrow abnormalities leading to leukemia (myelodysplastic syndrome)
- •Weight changes
- •Metabolic disorders (tumor lysis syndrome)
- •Anxiety
- •Confusion
- •Tingling sensation
- •Severe bleeding
- •Low blood pressure
- •Abdominal pain
- •Gastrointestinal bleeding (blood in vomit/stool, black tarry stools)
- •Mucosal inflammation
- •Pancreatitis (inflammation of the pancreas)
- •Liver abnormalities
- •Skin inflammations (redness)
- •Nail abnormalities (e.g., nail detachment, changes in nail surface/structure)
- •Rash
- •Changes in whites of eyes color
- •Skin discoloration
- •Extravasation (leakage into surrounding tissue) symptoms: redness, swelling, pain, burning sensation, skin discoloration, tissue necrosis (cell death)
- •Abnormal liver and kidney function tests (elevated creatinine, urea nitrogen)
- •Kidney damage (nephropathy) causing swelling and weakness
- •Urine discoloration
- •Edema (swelling)
- •Taste disorders
- •Pneumonia (lung inflammation)
- •Heart muscle damage (cardiomyopathy) preventing the heart from pumping properly
- •Slow heartbeat
- •Sudden death
Important Warnings
- Do not use this medicine if you are allergic to mitoxantrone, sulfites, or any other ingredient.
- Do not use if you are pregnant (especially for MS treatment) or breastfeeding, as it can harm the baby.
- This medicine can harm your heart. Your doctor will check your heart function before and during treatment.
- Mitoxantron Ebewe can affect your blood cell counts. Your doctor will perform regular blood tests.
- This medicine is always given as a drip into a vein. It must not be given under the skin, into a muscle, an artery, or the spinal fluid, as this can cause severe damage.
Show 3 more warnings
- This medicine can turn your urine blue-green and may also cause a bluish tint to your skin, nails, and the whites of your eyes.
- You must use effective contraception during and after treatment, as the medicine can harm an unborn baby or affect fertility.
- Contact your doctor immediately if you experience fever, infections, unexplained bleeding or bruising, weakness, or difficulty breathing.