Mitomycin Substipharm
Mitomycin is a cancer medicine that slows down or stops the growth and division of cancer cells.
Form
injektio/infuusiokuiva-aine, liuosta varten
Strength
20 mg
Active Ingredient
Mitomycin
Manufacturer
Substipharm
How to Use
Dosage
Your doctor will determine the right dose and treatment schedule for you.
Method
This medicine is given as an injection or infusion into a vein, or directly into the bladder after it has been dissolved.
Important
Your doctor will determine your suitable dose and treatment schedule, which includes the maximum daily dose.
Possible Side Effects
COMMON
- •Lower production of blood cells in the bone marrow, leading to low white blood cells (increased infection risk) and low platelets (bruising and bleeding).
- •Feeling sick (nausea), throwing up (vomiting).
- •Shortness of breath, dry cough, crackling sounds when breathing in (lung inflammation).
- •Skin rash and irritation.
- •Numbness, swelling, and painful redness on the palms of your hands and soles of your feet.
- •Kidney problems (your kidneys might not work well).
- •Tissue inflammation and death if the medicine accidentally leaks out of the vein during injection.
- •Bladder inflammation (cystitis) that may include blood in urine or bladder bleeding.
- •Painful urination, needing to urinate often, sometimes at night.
- •Blood in your urine.
- •Local irritation of the bladder wall.
RARE
- •Inflammation of mucous membranes, including in the mouth.
- •Diarrhea.
- •Hair loss.
- •Fever.
- •Loss of appetite.
- •Life-threatening infection, blood poisoning (sepsis).
- •Low red blood cells with sudden kidney failure (hemolytic uremic syndrome).
- •Heart failure (after previous cancer treatments).
- •Increased blood pressure in the lung arteries, which can cause shortness of breath, dizziness, and fainting.
- •Blocking of lung veins (veno-occlusive lung disease).
- •Liver problems (liver dysfunction), increased liver enzymes, yellowing of skin and eyes (jaundice), blockage of small liver veins leading to fluid retention, enlarged liver, and increased bilirubin.
- •Widespread rash.
- •Severe allergic reaction (e.g., dizziness, rash, hives, itching, swelling of lips/face/throat, breathing problems, loss of consciousness).
- •Severe bladder inflammation where some bladder tissue may die (allergic or necrotizing cystitis).
- •Narrowing of the ureter (tube from kidney to bladder).
- •Reduced bladder capacity.
- •Hardening of the bladder wall (calcification, fibrosis).
- •Bladder perforation (a hole in the bladder).
Important Warnings
- Do not use if you are allergic to mitomycin or any other ingredients in this medicine.
- Do not use during breastfeeding.
- Do not use if your blood cell counts (red, white, or platelets) are very low, if you tend to bleed easily, or if you have a serious infection.
- For bladder use: do not use if your bladder wall has a hole.
- Tell your doctor if you have lung, liver, or kidney problems.
Show 4 more warnings
- Tell your doctor if you have bone marrow depression (your bone marrow isn't making enough blood cells), as this medicine can worsen it and increase the risk of serious infections.
- Mitomycin can affect your ability to have children. Women should avoid getting pregnant and use reliable birth control during and for at least 6 months after treatment. Men should also use birth control for 6 months after treatment.
- This medicine can make you feel sick and slow down your reactions; avoid driving or using machines, especially if you have consumed alcohol.
- Do not get vaccinated, especially with live vaccines, during treatment.