Mitomycin medac
Mitomycin medac is a cancer medicine that works by slowing down or stopping the growth and division of cancer cells.
Form
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Strength
40 mg
Active Ingredient
Mitomycin
Manufacturer
Medac Gesellschaft Für Klinische Spezialpräparate mbH
How to Use
Dosage
Typically 40 mg, administered once a week. Your doctor will decide the exact dose and frequency.
Method
The medicine is inserted into an empty bladder using a catheter. The solution should stay in the bladder for 1-2 hours, and you should move during this time to ensure the medicine covers the entire bladder. Do not drink too much fluid before, during, or after treatment. Empty your bladder in a sitting position to prevent splashing.
Important
Single dose per administration, typically once a week.
Possible Side Effects
COMMON
- •Bladder inflammation (cystitis), possibly with blood in the bladder/urine
- •Painful urination (dysuria)
- •Frequent urge to urinate at night (nocturia)
- •Excessively frequent urination (pollakisuria)
- •Blood in urine (hematuria)
- •Local irritation of the bladder wall
- •Local skin rash (local exanthema)
- •Allergic rash
- •Rash due to mitomycin contact (contact dermatitis)
- •Numbness, swelling, and painful redness of palms and soles (palmar-plantar erythema)
RARE
- •General body rash (generalized exanthema)
- •Bladder inflammation with tissue damage (necrotizing cystitis)
- •Allergic (eosinophilic) bladder inflammation (cystitis)
- •Narrowing of urinary tract (stenosis)
- •Reduced bladder capacity
- •Calcium hardening in the bladder wall (bladder wall calcification)
- •Partial conversion of bladder wall tissue to connective tissue (bladder wall fibrosis)
- •Reduced white blood cell count (leukopenia), which increases the risk of infections
- •Reduced platelet count (thrombocytopenia), which causes bruising and bleeding
- •Systemic allergic reactions
- •Lung disease with symptoms of shortness of breath, dry cough, and wheezing when breathing in (interstitial lung disease)
- •Elevated liver enzyme levels (elevated transaminases)
- •Hair loss (alopecia)
- •Nausea and vomiting
- •Diarrhea
- •Kidney disease (kidney failure) where urination is minimal or absent
- •Fever
Important Warnings
- Do not use if you are allergic to mitomycin or any of its ingredients.
- Do not breastfeed while using this medicine.
- Do not use if your bladder wall has a hole in it (is perforated).
- Do not use if you have a bladder infection (cystitis).
- Tell your doctor if you are not feeling well in general.
Show 9 more warnings
- Tell your doctor if you have problems with your lungs, liver, or kidneys.
- Tell your doctor if you are receiving radiation therapy or other cancer treatments.
- Tell your doctor if you have a condition where your bone marrow does not make enough blood cells (bone marrow depression), as this can worsen.
- If you can become pregnant, talk to your doctor, as this medicine may affect your ability to have children.
- If you experience stomach or pelvic pain right after or weeks/months after using this medicine, tell your doctor immediately.
- Mitomycin can cause changes in your genes and may potentially increase the risk of cancer.
- Avoid direct contact with your skin and mucous membranes (like inside your nose or mouth).
- After using the medicine, sit when you urinate to prevent splashing. Always wash your hands and genital area well afterwards, especially the first time you urinate.
- If the medicine accidentally leaks outside your bladder, it can cause problems such as bladder damage, abscesses (pus pockets) in your abdomen, tissue death in surrounding areas, or a bladder fistula (an abnormal connection or opening).