Midive
Midive contains riociguat, a medicine that widens blood vessels leading from the heart to the lungs and improves physical ability.
Form
tabletti, kalvopäällysteinen
Strength
0.5 mg
Active Ingredient
Riociguat
Manufacturer
Adalvo Limited
How to Use
Dosage
The recommended starting dose is one 1 mg tablet three times a day for 2 weeks.
Method
Take tablets three times a day, every 6-8 hours, with or without food. If you have difficulty swallowing whole tablets, they can be crushed and mixed with water or soft food like applesauce immediately before use.
Important
Your doctor will increase the dose every two weeks up to a maximum of 2.5 mg three times a day (maximum daily dose 7.5 mg), unless you experience very low blood pressure.
Possible Side Effects
COMMON
- •Headache
- •Dizziness
- •Indigestion (dyspepsia)
- •Swelling of arms and legs (peripheral edema)
- •Diarrhea
- •Nausea or vomiting
RARE
- •Coughing up blood (hemoptysis)
- •Stomach inflammation (gastritis)
- •Inflammation of the digestive tract (gastroenteritis)
- •Decrease in red blood cells (anemia), seen as pale skin, weakness, or shortness of breath
- •Irregular, strong, or fast heartbeats (palpitations)
- •Low blood pressure (hypotension)
- •Nosebleed (epistaxis)
- •Difficulty breathing through the nose (nasal congestion)
- •Pain in the stomach, intestines, or abdominal area (gastrointestinal and abdominal pain)
- •Heartburn (gastroesophageal reflux disease)
- •Difficulty swallowing (dysphagia)
- •Constipation
- •Abdominal bloating (flatulence)
- •Sudden bleeding in the lungs (pulmonary hemorrhage)
Important Warnings
- Do not take if you are allergic to riociguat or any other ingredient in this medicine.
- Do not take if you are using PDE5 inhibitors (e.g., sildenafil, tadalafil, vardenafil).
- Do not take if you have severe liver disease.
- Do not take if you are pregnant.
- Do not take if you are using nitrates or nitric oxide donors (e.g., amyl nitrite).
Show 3 more warnings
- Do not take if you are using other soluble guanylate cyclase stimulators like Midive (e.g., vericiguat).
- Do not take if you have low blood pressure (systolic below 90 mmHg for children 6-12 years, or below 95 mmHg for patients 12 years and older) before starting treatment.
- Do not take if you have increased blood pressure in your lungs due to lung scarring of unknown cause (idiopathic pulmonary fibrosis).