Metopirone
Metopirone is used to test how your pituitary gland works and to treat high cortisol levels in Cushing's syndrome.
Form
kapseli, pehmeä
Strength
250 mg
Active Ingredient
Metyrapone
Manufacturer
Esteve Pharmaceuticals S.A.S.
How to Use
Dosage
For pituitary tests: 30 mg per kg for a single dose test, or 500-750 mg every four hours for multiple dose tests. For Cushing's syndrome treatment, the dose is individualized, from 250 mg to 6 g daily.
Method
Take capsules with milk or yogurt, or after a meal.
Important
Maximum 6 grams (24 capsules) per day.
Possible Side Effects
COMMON
- •Weakness
- •Dizziness
- •Fatigue
- •Loss of appetite
- •Nausea
- •Vomiting
- •Stomach pain
- •Diarrhea
- •Headache
- •High blood pressure
- •Allergic skin reaction (like hives, rash, itching)
- •Joint pain
- •Swelling in arms, legs, hands, or feet
- •Bleeding or bruising that lasts longer than usual, blood from gums or nose, or constant tiredness (these can be signs of low blood cells)
- •Low blood potassium
- •Drowsiness or feeling sleepy
- •Low blood pressure
- •Acne
- •Excessive hair growth in unusual places
- •Muscle pain
RARE
- •Abnormal liver function (like high liver enzymes)
- •Low counts of red blood cells, white blood cells, or platelets
- •Hair loss
- •Lung infection
Important Warnings
- Do not take if you have Addison's disease or are allergic to metyrapone or any other ingredient in this medicine.
- Tell your doctor if you have low hormone levels or liver disease.
- Talk to your doctor if you are taking glucocorticoids.
- Metopirone can temporarily lower your cortisol levels; your doctor may give you replacement medicine.
- Contact your doctor immediately if you develop breathing difficulties or fever during treatment.
Show 5 more warnings
- If you take Metopirone for a long time, your blood pressure might increase.
- Do not use with paracetamol without consulting your doctor.
- Do not use during pregnancy or breastfeeding; metyrapone may pass to the baby.
- Avoid driving or operating machinery if you feel dizzy or drowsy.
- This medicine contains sodium ethyl parahydroxybenzoate (E215) and sodium propyl parahydroxybenzoate (E217) which may cause allergic reactions.