Methotrexat Ebewe
Methotrexat Ebewe is a cancer medicine used to destroy cancer cells in specific types of cancers such as leukemia, breast cancer, and bone cancer.
Form
infuusiokonsentraatti, liuosta varten
Strength
100 mg/ml
Active Ingredient
Methotrexate
Manufacturer
Ebewe Pharma Ges.m.b.H. Nfg.KG
How to Use
Dosage
The dose prescribed by your doctor depends on your illness, health condition, age, weight, body surface area, and kidney function.
Method
The medicine is administered intravenously by healthcare professionals; you should not administer it yourself.
Important
The maximum daily dose is determined individually by your doctor.
Possible Side Effects
COMMON
- •Changes in white blood cell and platelet counts.
- •Headache, dizziness.
- •Cough.
- •Loss of appetite, diarrhea (especially within 24-48 hours of dose), abdominal pain, nausea, vomiting, inflammation and sores in mouth/throat.
- •Increased liver enzyme levels.
- •Hair loss.
- •Decreased creatinine excretion (indicates kidney problems).
- •Fatigue, general malaise.
- •Shingles (Herpes zoster).
- •Changes in red blood cell count (anemia); bone marrow damage that can cause a rapid decrease in white blood cells (agranulocytosis) or all blood cells (pancytopenia).
- •Drowsiness, tingling.
- •Conjunctivitis (red eye).
- •Rash, redness, itching, skin sores.
RARE
- •Increased risk of infections/inflammation due to a weakened immune system.
- •Lymphoma (a type of cancer that may go away after stopping methotrexate treatment).
- •Diabetes.
- •Depression.
- •One-sided paralysis, confusion, seizures.
- •Inflammation of blood vessels (vasculitis), allergic vasculitis.
- •Increased connective tissue in lungs (pulmonary fibrosis), fluid accumulation in the lung lining (pleural effusion).
- •Liver damage (hepatotoxicity), fatty liver, fibrosis, cirrhosis, decreased serum albumin levels.
- •Severe toxic skin reactions: herpes-like blisters (herpetiform skin lesions).
- •Hives, skin darkening, subcutaneous nodules, delayed wound healing.
- •Sunburn-like reactions due to increased skin sensitivity to sunlight.
- •Joint or muscle pain, bone loss (osteoporosis).
- •Bladder inflammation and sores (possibly with blood in urine); urination difficulties, painful urination, decreased or no urine output.
- •Fetal malformations.
- •Vaginal inflammation and sores.
- •Fever.
- •Megaloblastic anemia, mood swings, temporary perception disorders, paralysis, speech difficulties, bone marrow inflammation (myelopathy), severe vision disorders, blood clots in retinal veins.
- •Low blood pressure (hypotension), blood clot complications in veins and arteries (thromboembolism), sore throat (pharyngitis), breathing pauses.
- •Gastrointestinal inflammation, gingivitis, black or tarry stools, liver inflammation (hepatitis).
- •Acne, red or purple skin spots, lumpy rash, bruises, darkened nails, nail detachment.
- •Stress fractures.
- •Increased urea, creatinine, and uric acid levels in blood (indicating kidney problems), miscarriage.
- •Menstrual cycle changes and decreased sperm production, which return to normal after treatment ends.
- •Herpes simplex hepatitis, fungal infections (histoplasmosis, cryptococcosis), viral infections (cytomegalovirus, pneumonia), bacterial infections (nocardiosis).
- •Anemia due to insufficient red blood cell production (aplastic anemia), decreased white blood cells (eosinophilia, neutropenia), swollen glands, lymphoproliferative disorders.
- •Low antibody levels, muscle weakness and pain in limbs, metallic taste in mouth, acute aseptic meningitis, nerve damage.
- •Eye swelling, eyelid inflammation, increased tear production, light sensitivity, temporary blindness, vision loss.
- •Pericarditis, heart failure due to blood accumulation in pericardium (cardiac tamponade), fluid accumulation in pericardium (pericardial effusion).
- •Chronic damage to lung structure, asthma-like reactions, blood vomiting, liver cell breakdown (acute liver necrosis), liver failure.
- •Hair follicle infections (furunculosis), visible and permanent widening of capillaries under the skin (telangiectasia), nail bed inflammation, blood in urine, protein in urine, fetal death.
- •Decreased egg and sperm production, infertility, menstrual cycle issues, decreased libido, impotence, vaginal discharge, male breast enlargement (gynecomastia).
- •Nervous system damage (neurotoxicity), brain membrane inflammation, leg paralysis (paraplegia), whole body stiffness (stupor), muscle movement coordination problems, dementia, increased cerebrospinal fluid pressure, chest pain, oxygen deficiency (hypoxia), peritonitis, tongue inflammation, DRESS syndrome, osteonecrosis (bone tissue death), impaired bladder and genital function (urogenital dysfunction), chills, skin redness and peeling, jaw bone damage.
Important Warnings
- Do not use if you are allergic to methotrexate or any other ingredient in this medicine.
- Do not use if you have severe kidney or liver disease.
- Do not use if you have a severe blood cell formation disorder or a weakened immune system (e.g., AIDS).
- Do not use if you have a severe or active infection, or sores in your mouth, throat, or other parts of your digestive system.
- Do not use if you are pregnant, breastfeeding, or planning to become pregnant (if treatment is not for cancer).
Show 3 more warnings
- Do not get live vaccines during Methotrexat Ebewe treatment.
- Avoid alcohol and other medicines that can harm your liver during treatment.
- Tell your doctor if you have diabetes and use insulin, chronic infections, liver or kidney disease, lung problems, obesity, or abnormal fluid buildup in your body.