Methotrexat Accord
Methotrexat Accord is a cancer medicine that slows down the growth of cancer cells.
Form
injektioneste, liuos
Strength
25 mg/ml
Active Ingredient
Methotrexate
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
The dose is determined by your doctor based on your illness, health, age, weight, and body surface area.
Method
The medicine is given as an injection into a muscle, vein, artery, or spine by a healthcare professional.
Important
The maximum daily dose is determined by your illness and your doctor's instructions.
Possible Side Effects
COMMON
- •Loss of appetite, nausea, vomiting, abdominal pain, indigestion
- •Inflammation and sores in the mouth and throat
- •Increased liver enzyme levels
- •Shingles (Herpes zoster)
- •Blood effects, such as anemia, low white blood cell count, or low platelet count
- •Fatigue, headache, drowsiness
- •Dry cough, shortness of breath, chest pain, fever
- •Diarrhea
- •Rash, skin redness, and itching
RARE
- •Lack of all blood cells (pancytopenia), missing white blood cells (agranulocytosis)
- •Inflammation of blood vessels
- •Severe allergic reactions and allergic blood vessel inflammation
- •Dizziness, confusion, depression
- •Seizures, brain disease (encephalopathy)
- •Lymphoma (lymph node cancer)
- •Lung scarring (pulmonary fibrosis)
- •Stomach and intestinal bleeding and ulcers
- •Pancreatitis
- •Liver scarring and cirrhosis, fatty liver
- •Diabetes-related problems
- •Low albumin level
- •Sunburn-like reactions due to increased skin sensitivity to sunlight
- •Hives
- •Severe skin pigmentation
- •Hair loss, shingles, painful psoriatic lesions
- •Increased rheumatic nodules
- •Severe skin and mucous membrane effects (e.g., Stevens-Johnson syndrome)
- •Bladder inflammation and ulcers, blood in urine, painful urination
- •Vaginal inflammation and ulcers
- •Bone fragility (osteoporosis), joint and muscle pain
- •Heart sac inflammation, fluid around the heart
- •Megaloblastic anemia (a type of blood deficiency)
- •Mood swings
- •Partial paralysis
- •Speech difficulties (dysarthria, aphasia)
- •Bone marrow disease (myelopathy)
- •Vision problems, blurred vision
- •Blood clots (in brain, deep veins, and retina)
- •Low blood pressure
- •Throat inflammation, breathing pauses, asthma
- •Gum inflammation
- •Small intestine inflammation
- •Blood in stool
- •Poor nutrient absorption
- •Liver damage
- •Acne, skin sores, nail color changes, bruises
- •Bone fractures
- •Kidney failure, low urine output, high nitrogen in blood, no urine production
- •High uric acid level in blood
- •Increased creatinine and urea levels (sign of kidney problems)
- •Abnormal breast development
- •High blood sugar (diabetes)
- •Infections, blood poisoning, opportunistic infections
- •Severe bone marrow failure, aplastic anemia, enlarged lymph nodes, overgrowth of white blood cells, eosinophilia, neutropenia
- •Immunodeficiency
- •Low gammaglobulin level
- •Insomnia
- •Intellectual disability, such as impaired thinking, memory, and reasoning
- •Joint and/or muscle pain, weakness
- •Myasthenia (muscle weakness)
- •Abnormal sensations, taste changes (metallic taste)
- •Meningism (paralysis, vomiting), acute aseptic meningitis
- •Conjunctivitis, retinopathy, vision loss, eyelid swelling
- •Eyelid follicle inflammation, tearing, and light sensitivity
- •Syndrome caused by tumor cell breakdown
- •Lung problems, shortness of breath, pneumonia
- •Lung infections
- •Fluid in the pleural cavity
- •Colon enlargement (toxic megacolon)
- •Reactivation of chronic hepatitis, acute liver degeneration, shingles, liver inflammation, liver failure
- •Painful swelling of skin around nails
- •Dilation of small skin blood vessels (paronychia)
- •Allergic vasculitis, sweat gland inflammation
- •Protein in urine (proteinuria)
- •Loss of libido, impotence
- •Menstrual disorders
- •Vaginal discharge
- •Infertility
- •Fever, poor wound healing
Important Warnings
- Do not use this medicine if you are allergic to methotrexate or any other ingredient in it.
- Do not use if you have severe liver disease, kidney disease, blood disorders, or a serious infection like tuberculosis or HIV.
- Do not use if you have sores in your mouth, throat, stomach, or intestines.
- Do not use if you are breastfeeding.
- Do not use if you have increased alcohol consumption.
Show 7 more warnings
- Do not receive live vaccines during treatment with Methotrexat Accord.
- This medicine can lower your body's ability to fight infections and increase your risk of bleeding.
- If you cough up or spit blood, contact your doctor immediately.
- This medicine can temporarily affect sperm and egg production, possibly leading to infertility. Discuss sperm banking options before treatment if you are male.
- If you are a woman, avoid getting pregnant during treatment and for at least six months after treatment ends, as this medicine can cause birth defects and miscarriage. Use effective contraception.
- If you are a man, avoid making a woman pregnant during treatment and for at least three months after treatment ends.
- This medicine can make your skin more sensitive to sunlight. Avoid strong sun exposure and do not use sunbeds without doctor's advice.