Melphalan Macure
Melphalan Macure contains melphalan, a chemotherapy drug used to treat cancer by reducing the number of abnormal cells in your body.
Form
injektio/infuusiokuiva-aine ja liuotin, liuosta varten
Strength
50 mg
Active Ingredient
Melphalan hydrochloride
Manufacturer
Macure Pharma ApS
How to Use
Dosage
Your doctor will decide your dose of Melphalan Macure based on your weight, body surface area, other medicines you take, your illness, age, and kidney function. Your doctor will also do regular blood tests to check your blood cell count and may adjust your dose based on these tests.
Method
Melphalan Macure is given as an infusion (drip) into a vein or directly into an artery in a specific body part (perfusion).
Important
The maximum daily dose is determined by your doctor based on your individual needs and response to treatment.
Possible Side Effects
COMMON
- •Decrease in blood cells and platelets.
- •Nausea, vomiting, and diarrhea (especially with high doses).
- •Mouth sores (especially with high doses).
- •Hair loss (especially with high doses).
- •Tingling or warm sensation at the injection site.
- •Muscle problems like wasting and pain when melphalan is given directly into an arm or leg.
RARE
- •Hair loss (with usual melphalan doses).
- •High levels of urea in the blood in people with kidney disease being treated for myeloma.
- •Muscle problems like pain, tightness, tingling, burning, or numbness (compartment syndrome) when melphalan is given directly into an arm or leg.
- •Inflammation of the stomach and intestinal lining.
- •Acute kidney injury.
- •A condition where red blood cells are destroyed too quickly, causing fatigue, shortness of breath, dizziness, headache, and yellow skin or eyes.
- •Lung problems, causing cough, wheezing, and difficulty breathing.
- •Liver problems, shown in blood tests or as jaundice (yellowing of eyes and skin).
- •Mouth sores (with normal melphalan doses).
- •Skin rash or itching.
- •Leukemia (blood cancer).
- •In women: absence of menstruation (amenorrhea).
- •In men: absence of sperm in semen (azoospermia).
- •Muscle tissue death (muscle necrosis).
- •Breakdown of muscle fibers (rhabdomyolysis).
- •Formation of a blood clot in a deep vein, especially in the leg (deep vein thrombosis) and blockage of a lung artery (pulmonary embolism).
Important Warnings
- Do not take if you are allergic to melphalan or any other ingredients in this medicine.
- Do not breastfeed while taking this medicine.
- Tell your doctor if you have recently had radiation therapy or chemotherapy.
- Inform your doctor if you have kidney problems.
- Be careful with vaccinations, especially live vaccines, as they can cause infection during melphalan treatment.
Show 11 more warnings
- Tell your doctor if you have or have had blood clots (in leg, lung, or elsewhere) or if you are at high risk of developing them.
- If you have multiple myeloma and use combined oral contraceptives, discuss this with your doctor due to increased risk of blood clots.
- Do not use if you are pregnant or planning to become pregnant, as it can cause permanent damage to the fetus. Both men and women should use effective contraception during treatment and for a period afterward.
- Seek immediate medical attention if you experience severe allergic reactions, which can include rash, hives, swelling of the face, eyelids, or lips, sudden wheezing or chest tightness, and fainting.
- Contact your doctor if you have any signs of fever or infection (e.g., sore throat, mouth sores, or problems urinating).
- Report to your doctor any unexpected bruising or bleeding, extreme tiredness, dizziness, or shortness of breath, which might mean too few blood cells are being produced.
- Tell your doctor if you feel suddenly unwell (even with normal body temperature).
- Report muscle aches, stiffness, or weakness, and unusually dark (brown or red) urine, especially if melphalan is given directly into an arm or leg.
- Seek medical advice if you have symptoms of blood clots like shortness of breath, chest pain, or swelling in an arm or leg, especially if treated with melphalan along with lenalidomide, thalidomide, prednisone, or dexamethasone.
- If melphalan is injected directly into an arm or leg, some medicine might leak into surrounding tissue, causing discomfort, redness, or mild rash. Rarely, this can lead to skin tissue death, ulcers, and deeper tissue damage.
- A drop in white blood cells, which increases the risk of infection, is possible with this medication.