Loxentia
Loxentia is a medicine containing duloxetine that helps strengthen the muscles controlling urine for women with stress urinary incontinence.
Form
enterokapseli, kova
Strength
40 mg
Active Ingredient
Duloxetine hydrochloride
Manufacturer
KRKA d.d. Novo mesto
How to Use
Dosage
The usual dose is one 40 mg capsule twice a day, in the morning and late afternoon/evening. Your doctor may start you on a lower dose.
Method
Swallow the capsule whole with water.
Important
Do not take more than 80 mg (two 40 mg capsules) in a day, unless your doctor tells you to.
Possible Side Effects
COMMON
- •Nausea, dry mouth, or constipation
- •Feeling tired or weak
- •Trouble sleeping or feeling anxious
- •Headache, dizziness, or drowsiness
- •Numbness, tingling, or shaking
- •Blurred vision
- •High blood pressure or flushing
- •Diarrhea, stomach pain, vomiting, or heartburn
- •Increased sweating
- •Muscle twitching
- •Loss of appetite
- •Feeling agitated or decreased sex drive
RARE
- •Severe allergic reaction with trouble breathing, dizziness, or swelling of the face/tongue
- •Low sodium levels in the blood, causing dizziness, weakness, confusion, or seizures
- •Thoughts of harming yourself or suicide, mania, or aggression
- •Serotonin syndrome (muscle jerks, agitation, hallucinations, fever, nausea, diarrhea)
- •Seizures or sudden uncontrolled muscle movements
- •Feeling restless or unable to sit or stand still
- •Increased pressure in the eye (glaucoma)
- •Liver problems, including yellowing of the skin or eyes (jaundice)
- •Severe skin reactions like Stevens-Johnson syndrome (blisters on skin, mouth, eyes)
- •Difficulty urinating, urinating more often, or painful urination
- •Abnormal vaginal bleeding or very heavy bleeding after childbirth
- •Signs of stress cardiomyopathy (chest pain, shortness of breath, irregular heartbeat)
- •Throat tightness or nosebleeds
- •Cough, wheezing, or shortness of breath with a high fever
Important Warnings
- Do not take Loxentia if you are allergic to duloxetine or any other ingredients.
- Do not take if you have severe liver or kidney disease.
- Do not take if you are using certain other medicines like MAO inhibitors, fluvoxamine, ciprofloxacin, or enoxacin. Always tell your doctor about all medicines you take.
- Talk to your doctor if you take other medicines for depression, migraines (triptans), mental health conditions, or buprenorphine, as this can cause a serious condition called serotonin syndrome.
- Avoid taking St. John's Wort (a herbal remedy) with Loxentia.
Show 5 more warnings
- Talk to your doctor if you have high blood pressure, heart disease, seizures, a history of mania or bipolar disorder, glaucoma (high eye pressure), or bleeding problems.
- Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Loxentia is not recommended during breastfeeding.
- Loxentia can cause drowsiness or dizziness. Do not drive or operate machinery until you know how it affects you.
- If you have a sugar intolerance (like sucrose), tell your doctor.
- If you have thoughts of harming yourself or suicide, contact your doctor or go to a hospital immediately.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Serotonergic. Consider risk of urinary retention. Increases risk of falls. Consider potential interactions. (updated 12.2.2024)