Losartan/Hydrochlorothiazide Orion
This medicine helps lower high blood pressure by relaxing blood vessels and removing excess water and salt from the body.
Form
tabletti, kalvopäällysteinen
Strength
100 mg / 25 mg
Active Ingredient
Losartan potassium
Manufacturer
Orion Corporation
How to Use
Dosage
Usually one 50 mg/12.5 mg tablet once daily.
Method
Take the tablets whole with water.
Important
The maximum daily dose is two 50 mg/12.5 mg tablets or one 100 mg/25 mg tablet.
Possible Side Effects
COMMON
- •Cough, upper respiratory infection, stuffy nose, sinus inflammation
- •Diarrhea, stomach pain, nausea, indigestion
- •Muscle pain or cramps, leg pain, back pain
- •Insomnia, headache, dizziness
- •Weakness, tiredness, chest pain
- •Increased potassium levels (which can cause abnormal heart rhythm), decreased hemoglobin levels
- •Changes in kidney function, including kidney failure
- •Low blood sugar levels (hypoglycemia)
RARE
- •Severe allergic reaction (rash, itching, swelling of face, lips, throat or tongue, difficulty breathing or swallowing)
- •Acute respiratory distress syndrome (severe shortness of breath, fever, weakness, confusion)
- •Anemia, red or brown spots on skin (sometimes with joint pain, swelling of hands/feet/abdomen), bruising, low white blood cells or platelets, clotting problems
- •Loss of appetite, increased uric acid or gout, high blood sugar, electrolyte imbalance
- •Anxiety, nervousness, panic attacks, confusion, depression, unusual dreams, sleep problems, drowsiness, memory problems
- •Tingling or numbness, limb pain, tremor, migraine, fainting
- •Blurred vision, burning or stinging eyes, conjunctivitis (pink eye), decreased vision, yellow vision
- •Ringing in ears, dizziness
- •Low blood pressure (especially when standing up, feeling dizzy or weak), chest pain (angina pectoris), irregular heartbeat, stroke, heart attack, palpitations
- •Inflammation of blood vessels, often with rash or bruising
- •Sore throat, shortness of breath, bronchitis, pneumonia, fluid in lungs (causing breathing problems), nosebleeds, runny or stuffy nose
- •Constipation, severe constipation, gas, stomach problems, cramps, vomiting, dry mouth, salivary gland inflammation, toothache
- •Jaundice (yellowing of eyes or skin), pancreatitis (inflammation of pancreas)
- •Hives, itching, skin inflammation, rash, skin redness, light sensitivity, dry skin, flushing, sweating, hair loss
- •Pain in arms, shoulders, hips, knees, or other joints, swollen joints, stiffness, muscle weakness
- •Frequent nighttime urination, abnormal kidney function including kidney inflammation, urinary tract infection, sugar in urine
- •Decreased sexual desire, impotence
- •Facial swelling, local swelling (edema), fever
- •Liver inflammation (hepatitis), abnormal liver function tests
- •Intestinal angioedema (swelling in the intestine with symptoms such as stomach pain, nausea, vomiting, diarrhea)
- •Flu-like symptoms
- •Unexplained muscle pain with dark (tea-colored) urine (rhabdomyolysis)
- •Low sodium levels in blood (hyponatremia)
- •General feeling of illness (malaise)
- •Taste disorder (dysgeusia)
- •Skin and lip cancer (non-melanoma skin cancer)
- •Decreased vision or eye pain due to high eye pressure (possible signs of fluid accumulation in the choroid or acute angle-closure glaucoma)
Important Warnings
- Do not take if you are allergic to losartan, hydrochlorothiazide, or any other ingredients in this medicine.
- Do not take if you are allergic to other sulfonamide medicines (like some antibiotics).
- Do not take if you are more than 3 months pregnant, as it can harm your baby.
- Do not take if you have severe liver problems or severe kidney problems and your kidneys do not make urine.
- Do not take if you have low potassium or sodium levels, or high calcium levels that cannot be corrected by treatment.
Show 11 more warnings
- Do not take if you have gout.
- Do not take if you have diabetes or kidney problems and are taking another blood pressure medicine called aliskiren.
- Contact your doctor immediately if you experience decreased vision or eye pain, as these can be signs of serious eye problems that may lead to permanent vision loss.
- Seek immediate medical attention if you develop severe shortness of breath or breathing difficulties after taking this medicine.
- Tell your doctor if you have had swelling of your face, lips, throat, or tongue.
- This medicine may increase your risk of skin and lip cancer. Protect your skin from sun and UV light while taking it.
- Do not stop taking this medicine on your own if you experience stomach pain, nausea, vomiting, or diarrhea; consult your doctor.
- Do not give this medicine to children.
- Avoid grapefruit juice while taking this medicine.
- Do not drive or operate machinery until you know how this medicine affects you.
- If you have an intolerance to certain sugars (like lactose), talk to your doctor before taking this medicine.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)