Losartan/Hydrochlorothiazide Orion
This medicine treats high blood pressure by relaxing blood vessels and helping your body get rid of excess water and salt.
Form
tabletti, kalvopäällysteinen
Strength
50 mg / 12.5 mg
Active Ingredient
Losartan potassium
Manufacturer
Orion Corporation
How to Use
Dosage
Typically, one 50 mg/12.5 mg tablet once daily. Your doctor may adjust this to one 100 mg/25 mg tablet or two 50 mg/12.5 mg tablets daily.
Method
Swallow the tablet whole with a glass of water, with or without food.
Important
The maximum daily dose is two 50 mg/12.5 mg tablets or one 100 mg/25 mg tablet.
Possible Side Effects
COMMON
- •Cough, upper respiratory infection, stuffy nose, sinus problems
- •Diarrhea, stomach pain, nausea, indigestion
- •Muscle aches or cramps, leg pain, back pain
- •Trouble sleeping, headache, dizziness
- •Feeling weak, tired, chest pain
- •Increased potassium in blood (may cause irregular heartbeat), decreased hemoglobin (a substance in red blood cells), changes in kidney function including kidney failure
- •Low blood sugar (hypoglycemia)
RARE
- •Severe allergic reaction: hives, itching, swelling of the face, lips, mouth, or throat, causing difficulty breathing or swallowing. Seek immediate medical help.
- •Sudden severe breathing difficulty: signs include intense shortness of breath, fever, weakness, and confusion. Seek immediate medical help.
- •Anemia (low red blood cells), red or brown spots on the skin, bruising, low white blood cells, problems with blood clotting, or low platelets (cells that help blood clot)
- •Loss of appetite, increased uric acid (which can cause gout), high blood sugar, problems with body salts (electrolytes)
- •Anxiety, nervousness, panic attacks, confusion, depression, unusual dreams, sleep problems, drowsiness, memory loss
- •Tingling or prickling sensations, limb pain, shaking, migraine, fainting
- •Blurred vision, burning or stinging in eyes, conjunctivitis (eye infection), decreased vision, seeing yellow, ringing or buzzing in ears, spinning sensation (vertigo)
- •Low blood pressure (especially when standing up), chest pain during activity, irregular heartbeat, stroke, heart attack, fast heartbeat
- •Inflammation of blood vessels (often with rash or bruising), sore throat, shortness of breath, bronchitis, pneumonia, fluid in lungs, nosebleeds, runny or stuffy nose
- •Constipation (including severe), gas, stomach upset or cramps, vomiting, dry mouth, inflamed salivary glands, toothache, jaundice (yellow skin/eyes), inflamed pancreas or liver, abnormal liver function tests, swelling in the intestines (with stomach pain, nausea, vomiting, diarrhea)
- •Hives, itching, skin inflammation, rash, red skin, sensitivity to light, dry skin, flushing, sweating, hair loss
- •Pain in arms, shoulders, hips, knees, or other joints, swollen joints, stiffness, muscle weakness
- •Frequent urination at night, abnormal kidney function (including kidney inflammation), urinary tract infection, sugar in urine
- •Decreased sexual desire, impotence
- •Facial swelling, local swelling (edema), fever
Important Warnings
- Do not take if you are allergic to losartan, hydrochlorothiazide, or similar medicines called sulfonamides.
- Do not use if you are more than 3 months pregnant, and it should be avoided in early pregnancy, as it can harm your baby.
- Do not use if you have severe liver or kidney problems, or if your kidneys do not produce urine.
- Do not use if you have very low potassium or sodium, or very high calcium levels that cannot be corrected by treatment.
- Do not use if you have gout (a type of arthritis).
Show 8 more warnings
- Do not use if you have diabetes or kidney problems and are taking aliskiren for high blood pressure.
- Tell your doctor right away if you have blurry vision or eye pain, as this could lead to permanent vision loss if not treated.
- Get medical help immediately if you develop severe shortness of breath or breathing difficulties after taking this medicine.
- Tell your doctor if you have ever had swelling of your face, lips, throat, or tongue (angioedema).
- This medicine may slightly raise your risk of certain skin cancers with long-term use. Protect your skin from sun and UV light.
- Avoid alcohol and grapefruit juice while taking this medicine.
- This medicine is not for children.
- Eating too much salt can make this medicine less effective.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Effectiveness is reduced in renal impairment. Consider risk of orthostatic hypotension and hyponatraemia and -kalemia. (updated 19.5.2025)