Lorazepam Macure
Lorazepam Macure is a calming medicine (a benzodiazepine) used to reduce anxiety before procedures, manage severe anxiety, and treat certain types of seizures.
How to Use
Dosage
For procedures: 0.044-0.05 mg per kg body weight (up to 4 mg total), given by injection. For severe anxiety: 2-4 mg (0.05 mg per kg body weight) by injection, with a second dose possible after 2 hours. For seizures: 4 mg intravenously for adults; half for elderly; 0.1 mg per kg body weight (up to 4 mg total) intravenously for children 1 month and older.
Method
Given as an injection into a vein (intravenously) or a muscle (intramuscularly).
For adults, the maximum is usually 8 mg per day, given as two doses. For children under 5, a maximum of two doses per day.
Possible Side Effects
- •Tiredness
- •Daytime sleepiness
- •Drowsiness
- •Dizziness
- •Problems with coordination
- •Vomiting
- •Muscle weakness
- •Confusion
- •Depression
- •Blunted emotions
- •Sleep disturbances
- •Headache
- •Reduced alertness
- •Vision problems
- •Double vision
- •Nausea
- •Stomach problems
- •Skin reactions, hair loss
- •Changes in sex drive
- •Blood disorders
- •Temporary memory loss
- •Paradoxical reactions (e.g., aggression, excitement)
- •Low blood pressure
- •High blood pressure
- •Liver problems
- •Mental changes like agitation, irritability, aggression, paranoia, nightmares, hallucinations, severe mental illness (psychosis), and unusual behavior
- •Sudden allergic reactions (difficulty breathing, rash, fainting), which can be life-threatening
- •Severe blood disorders (low platelets, low white blood cells, low red and white blood cells)
- •Pain, redness, and swelling at the injection site
- •Dependence (can develop after several weeks of use)
- •Breathing problems during deep anesthesia
- •Withdrawal symptoms (if treatment is stopped suddenly)
- •Swelling
- •Suicidal thoughts or attempts
- •Speech difficulties
- •Seizures
- •Coma
- •Low body temperature
Important Warnings
- Do not use if you are allergic to lorazepam, other benzodiazepines, or any other ingredients.
- Do not use if you have myasthenia gravis (a disease causing muscle weakness).
- Do not use if you have severe breathing problems.
- Do not use if you have sleep apnea (breathing problems during sleep).
- Do not use if you have severe liver problems.
Show 15 more warnings
- Do not inject into an artery.
- Talk to your doctor if you have chronic breathing problems.
- Talk to your doctor if you have liver or kidney problems.
- Talk to your doctor if you are elderly or frail.
- Talk to your doctor if you have epilepsy.
- Talk to your doctor if you have acute narrow-angle glaucoma.
- Talk to your doctor if you are pregnant or planning to become pregnant.
- Talk to your doctor if you are breastfeeding, as the medicine can pass into breast milk.
- Do not drive or operate machinery for 24-48 hours after taking this medicine.
- You might not remember what happened right after you received the medicine.
- This medicine can affect people with depression and may cause suicidal thoughts. The dose must be reduced gradually.
- To lower the risk of dependence, use the lowest effective dose for the shortest time possible.
- Stopping this medicine suddenly can cause withdrawal symptoms like headache, muscle pain, extreme fear, anxiety, restlessness, confusion, irritability, mood swings, depression, and trouble sleeping.
- Do not drink alcohol for 48 hours after taking this medicine, as it can make the effects stronger.
- This medicine contains benzyl alcohol, which can cause serious breathing problems in young children. Do not give to newborns (under 4 weeks old) or to children under 3 years for more than one week without doctor's advice.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Sedative. For short-term use only. Increases the risk of drug addiction, cognitive disorder and traffic accidents. Increases risk of falls. Paradoxically, may increase anxiety, restlessness and aggression. (updated 15.1.2024)