Linatilsan
Linatilsan is a medicine that helps lower blood pressure and treat heart failure by widening blood vessels.
Form
tabletti
Strength
20 mg
Active Ingredient
Enalapril maleate
Manufacturer
Sandoz GmbH
How to Use
Dosage
For high blood pressure, the typical starting dose is 5-20 mg once a day, usually 20 mg once daily once controlled, up to 40 mg daily. For heart failure, start with 2.5 mg once daily, gradually increasing to 20 mg, up to 40 mg daily in two doses. For children, the dose depends on weight (2.5 mg for 20-<50kg, 5 mg for >=50kg) once daily, max 20-40 mg depending on weight. Your doctor will adjust your dose if you have kidney problems or are elderly.
Method
Take this medicine by mouth, with or without food.
Important
The maximum daily dose is 40 mg.
Possible Side Effects
COMMON
- •Blurred vision
- •Cough
- •Nausea
- •Feeling weak
- •Headache
- •Feeling down (depression)
- •Low blood pressure (may make you feel dizzy or faint)
- •Fainting
- •Chest pain
- •Changes in heart rhythm or fast heartbeat
- •Chest pain (angina pectoris)
- •Shortness of breath
- •Diarrhea
- •Abdominal pain
- •Changes in taste
- •Feeling tired
- •Rash, allergic reactions with swelling of arms, legs, face, lips, tongue, or throat, making it hard to swallow or breathe
- •High potassium levels in the blood (seen in blood tests)
- •Increased creatinine levels in the blood (seen in blood tests)
RARE
- •Anemia (low red blood cells)
- •Anxiety, confusion, drowsiness, trouble sleeping, nervousness, tingling or numbness, dizziness (spinning sensation), feeling shaky (due to low blood sugar)
- •Heart attack or stroke (in high-risk patients)
- •Runny nose, sore throat, hoarseness, breathing problems, or asthma
- •Bowel blockage, pancreas inflammation, vomiting, digestive problems, constipation, loss of appetite, stomach irritation, dry mouth, heartburn, pain or hunger in an empty stomach (stomach ulcer)
- •Excessive sweating, itching, hives, hair loss, protein in urine (seen in urine tests), severe skin redness, blistering, skin peeling in layers, hypersensitivity to sunlight
- •Impotence, muscle cramps, flushing, ringing in the ears, drowsiness, fever, breast enlargement in men
- •Kidney problems or failure, increase in blood urea, decrease in blood sodium (seen in blood tests), impaired liver function or hepatitis (can cause yellow skin/eyes)
- •Decrease in white and red blood cells and platelets, bone marrow depression (all seen in blood tests)
- •Swelling of the face, abnormal lymph nodes, swelling in the intestines (abdominal pain, nausea, vomiting, high blood calcium)
- •Reduced blood flow to fingers and toes causing redness and pain (Raynaud's syndrome)
- •Fluid in the lungs, runny or irritated nose, autoimmune disease, eosinophilic pneumonia (cough, fever, breathing difficulty), mouth ulcers, tongue inflammation, decreased urine output, decreased blood sugar
- •General feeling unwell, confusion, weakness, nausea, loss of appetite, irritability (may be related to a hormone imbalance called SIADH)
- •A complex reaction with symptoms like fever, inflamed blood vessels, muscle/joint pain, changes in blood count, rash, or sun sensitivity
Important Warnings
- Do not take if you are allergic to enalapril maleate, other ingredients, or other similar medicines (ACE inhibitors). Signs of allergy include itching, hives, wheezing, or swelling of hands, throat, mouth, or eyelids.
- Do not take if you are taking sacubitril/valsartan for heart failure, as it increases the risk of severe swelling (angioedema).
- Do not take if you are more than 3 months pregnant. It's also best to avoid it in early pregnancy.
- Do not take if you have diabetes or kidney problems and are taking aliskiren for high blood pressure.
- Stop taking and see a doctor right away if you get severe dizziness, feel like fainting (especially when starting treatment or increasing dose, or standing up), severe skin redness, blisters, or peeling skin.
Show 6 more warnings
- Tell your doctor right away if you experience yellowing of your skin or eyes (jaundice) or a persistent dry cough.
- Tell your doctor you are taking Linatilsan if you are having surgery, anesthesia, a procedure to remove cholesterol from your blood (LDL apheresis), or treatment for allergies (desensitization therapy for bee/wasp stings).
- Talk to your doctor before taking if you have kidney disease, a recent kidney transplant, are on dialysis, take diuretics, have a low-salt diet, severe diarrhea/vomiting, certain heart conditions (aortic stenosis, hypertrophic cardiomyopathy), collagen vascular disease, autoimmune disease, or are taking allopurinol (for gout) or procainamide (for irregular heart rhythm).
- Talk to your doctor if you are taking racecadotril, mTOR inhibitors (e.g., temsirolimus, sirolimus, everolimus), or vildagliptin, as they increase the risk of severe swelling (angioedema).
- Talk to your doctor if you have diabetes and are taking diabetes medicines (monitor blood sugar), or if you are taking potassium supplements, lithium (for mental illness), or other blood pressure medicines like ARBs (e.g., valsartan) or aliskiren.
- Talk to your doctor if you have a sugar intolerance (lactose intolerance).
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Reduce the dose already in mild renal impairment. Monitor renal function and potassium concentrations during the pharmacotherapy. Avoid concurrent use of NSAIDs. (updated 14.4.2025)