Leponex
Leponex is a medicine used to treat severe thought, feeling, and behavior problems caused by schizophrenia and Parkinson's disease, when other medicines have not worked.
Form
tabletti, suussa hajoava
Strength
200 mg
Active Ingredient
Clozapine
Manufacturer
Viatris Oy
How to Use
Dosage
Your doctor will usually start you on a small dose (e.g., 12.5 mg) which will be gradually increased based on your condition and how well you tolerate it.
Method
Place the orally disintegrating tablet on your tongue and let it dissolve before swallowing. You can swallow it with or without water.
Important
The maximum daily dose for schizophrenia is 900 mg. For Parkinson's disease, the maximum daily dose is 100 mg.
Possible Side Effects
COMMON
- •Drowsiness or tiredness
- •Dizziness
- •Increased saliva
- •Weight gain
- •Blurred vision
- •Headache
- •Tremors
- •Stiffness
- •Restlessness
- •Seizures
- •Muscle twitching
- •Difficulty starting movements
- •Difficulty staying still
- •Changes in heart ECG
- •High blood pressure
- •Dizziness or weakness upon standing up
- •Dry mouth
- •Urinary incontinence
- •Difficulty urinating
- •Increased sweating
- •Fever
- •Speech problems (e.g., slurred speech)
- •Sudden fainting or loss of consciousness with muscle weakness
- •High white blood cell count (leukocytosis)
- •High count of a certain type of white blood cells (eosinophilia)
RARE
- •Speech disorders (e.g., stammering)
- •Weakness, dizziness or fainting when standing up (may increase risk of falls)
- •Low red blood cell count (anemia)
- •Restlessness, agitation, confusion, delirium
- •High blood sugar
- •Diabetes
- •Blood clot in the lungs (thromboembolism)
- •Liver inflammation (hepatitis), yellow skin, dark urine, itching
- •High levels of creatine kinase in blood
- •Pancreatitis (severe upper abdominal pain radiating to the back, with nausea and vomiting)
- •Fainting and muscle weakness due to significant drop in blood pressure
- •Difficulty swallowing (food may go down the wrong pipe)
- •Nausea, vomiting, and/or poor appetite
- •Weight gain or increased obesity
- •Breathing pauses during sleep, possibly with snoring
- •High platelet count, which can lead to blood clots
- •Uncontrolled movements of the mouth, tongue, or limbs
- •Obsessive thoughts and compulsive behavior (OCD symptoms)
- •Rash or other skin reactions
- •Swelling in front of the ear (enlarged salivary gland)
- •Breathing difficulties
- •Very high triglyceride or cholesterol levels in the blood
- •Sudden unexplained death
- •Prolonged painful erection (priapism)
- •Spontaneous bleeding or bruising (due to low platelets)
- •Symptoms from uncontrolled blood sugar (nausea, vomiting, stomach pain, thirst, increased urination, confusion)
- •Symptoms of kidney inflammation (nausea, vomiting, tiredness, weight loss)
- •Changes in brainwave patterns (EEG)
- •Diarrhea
- •Abdominal discomfort, heartburn, stomach pain after meals
- •Muscle weakness, spasms, muscle pain
- •Nasal congestion
- •Bedwetting
- •Sudden uncontrolled increase in blood pressure (pseudopheochromocytoma)
- •Uncontrolled twisting of the body to one side (pleurototonus)
- •Male ejaculatory disorder (semen goes into bladder, not out through penis)
- •Rash, purplish-red spots, fever, and itching due to vasculitis
- •Diarrhea due to colon inflammation, abdominal pain, fever, changes in skin color, 'butterfly rash' on face, joint pain, muscle pain, fever, and weakness (lupus erythematosus)
- •Restless legs syndrome (irresistible urge to move legs or arms, relieved by movement)
- •Symptoms of low blood pressure (weakness, dizziness, fainting, blurred vision, unusual tiredness, cold sweats, or nausea)
- •Symptoms of blood clots in leg veins (swelling, pain, and redness in the leg), which can travel to the lungs causing chest pain and breathing difficulties
- •Symptoms of cholinergic syndrome (heavy sweating, headache, nausea, vomiting, and diarrhea)
- •Significantly reduced urine output (sign of kidney failure)
- •Allergic reaction (swelling of face, mouth, throat, and tongue, which may be itchy or painful)
- •Sharp chest or abdominal pain with shortness of breath, cough, or fever (muscle disease/bowel perforation)
- •Extremely strong and severe skin reactions (DRESS syndrome), rash with or without blisters, skin irritation, swelling, fever, and flu-like symptoms
- •Inflammation of the heart muscle (myocarditis), cardiomyopathy, cardiac arrest, pericarditis, fluid accumulation around the heart, chest pressure
- •Irregular heartbeat, atrial fibrillation, palpitations
- •Liver disease/damage (jaundice, severe weakness, nausea, vomiting, loss of appetite, abdominal pain, abdominal swelling)
- •Neuroleptic malignant syndrome (sudden high fever, muscle stiffness, unconsciousness)
Important Warnings
- Do not take if you are allergic to clozapine or any other ingredients in the medicine.
- You cannot have regular blood tests.
- You have previously had a low white blood cell count, especially if caused by medication.
- You had to stop Leponex treatment due to severe side effects (e.g., severe lack of white blood cells or heart problems).
- You have or have had a bone marrow disease.
Show 8 more warnings
- You have uncontrolled epilepsy (seizures).
- You have a severe kidney, heart, or liver disease.
- You have severe constipation or a paralyzed bowel (paralytic ileus).
- You experience cold-like symptoms, fever, sore throat, or any other signs of infection. Contact your doctor immediately.
- You suddenly develop a high fever and muscle stiffness that could lead to unconsciousness.
- Your heart beats fast or irregularly, you have palpitations, shortness of breath, chest pain, or unexplained tiredness.
- You experience nausea, vomiting, and/or loss of appetite.
- You have constipation, stomach pain, tenderness in the stomach area, fever, bloating, and/or bloody diarrhea.