Lenvatinib Sandoz
Lenvatinib Sandoz is a cancer medicine used in adults to treat advanced thyroid cancer, liver cancer, and endometrial cancer.
Form
kapseli, kova
Strength
4 mg
Active Ingredient
Lenvatinib besilate
Manufacturer
Sandoz A/S
How to Use
Dosage
The dosage varies based on your condition and body weight. For thyroid cancer, it's usually 24 mg once daily. For liver cancer, it's 8-12 mg once daily depending on your weight. For endometrial cancer, it's 20 mg once daily, taken with another medicine. Your doctor will determine the exact dose.
Method
Swallow the capsules whole with water, with or without food. Do not open the capsules. Take the medicine at approximately the same time each day.
Important
The maximum daily dose is typically 24 mg, but it may vary depending on the condition and your doctor's instructions.
Possible Side Effects
COMMON
- •High or low blood pressure
- •Loss of appetite or weight loss
- •Nausea, vomiting, constipation, diarrhea, abdominal pain, or digestive issues
- •Severe fatigue or weakness
- •Hoarseness
- •Swelling in legs or general body swelling
- •Rash
- •Dry, sore, or inflamed mouth, or strange taste
- •Joint or muscle pain
- •Dizziness
- •Hair loss
- •Bleeding (e.g., nosebleeds, blood in urine, bruises, gum bleeding)
- •Sleep problems
- •Changes in urine protein levels or urinary tract infections
- •Headache
- •Back pain
- •Redness, soreness, and swelling of skin on hands and feet
- •Underactive or overactive thyroid
- •Changes in blood potassium and calcium levels (low)
- •Decreased white or red blood cell count
- •Changes in liver function blood test results
- •Low platelet count (bruising, poor wound healing)
- •Changes in blood magnesium levels (low) or cholesterol levels (high)
- •Changes in kidney function blood test results
- •Increased lipase and amylase levels (digestive enzymes)
- •Dehydration
- •Heart palpitations
- •Abdominal swelling or gas
- •Blood clots in lungs or other organs
- •Pancreatitis (inflammation of the pancreas)
- •Gallbladder inflammation
- •Feeling unwell
- •Colon inflammation (colitis)
- •Decreased adrenal hormone production
- •Hole (perforation) in stomach or intestine
- •Stroke
- •Liver failure
RARE
- •Painful infection or irritation near the anus
- •Mini-stroke
- •Liver damage
- •Severe pain in upper left abdomen (spleen infarction)
- •Wound healing problems
- •Jawbone damage (osteonecrosis)
- •Tumor Lysis Syndrome (TLS)
- •Other types of fistulas (abnormal connections between organs)
- •Enlarged or weakened blood vessel wall (aneurysm or dissection)
Important Warnings
- Do not use if you are allergic to lenvatinib or if you are breastfeeding.
- Tell your doctor if you have high blood pressure, heart or brain problems, or liver or kidney problems.
- Women who can become pregnant must use effective contraception during treatment and for one month afterwards.
- Inform your doctor if you have had recent surgery or radiation therapy, or if you are scheduled for major surgery.
- Be cautious if you are over 75, weigh less than 60 kg, or have abnormal connections between organs (fistulas).
Show 3 more warnings
- Tell your doctor if you have an aneurysm or a ruptured blood vessel.
- Pay special attention to any pain or problems in your mouth, teeth, or jaw.
- Report any signs of tumor lysis syndrome (TLS) immediately to your doctor, such as nausea, shortness of breath, or muscle cramps.