Lenvatinib ratiopharm
Lenvatinib ratiopharm is a medicine used to treat certain advanced cancers, including thyroid, liver, and endometrial cancer, by stopping cancer cell growth and blood supply.
Form
kapseli, kova
Strength
4 mg
Active Ingredient
Lenvatinib besilate
Manufacturer
ratiopharm GmbH
How to Use
Dosage
Your doctor will determine your exact dose, which typically ranges from 8 mg to 24 mg once a day, depending on your type of cancer and body weight.
Method
Swallow the capsules whole with water, with or without food, at about the same time each day. Do not open the capsules. If you have trouble swallowing, discuss other options with your doctor.
Important
Your doctor will decide your maximum daily dose based on your condition and any side effects.
Possible Side Effects
COMMON
- •Changes in blood pressure (high or low)
- •Decreased appetite or weight loss
- •Nausea, vomiting, diarrhea, constipation, or stomach pain
- •Severe tiredness or weakness
- •Hoarseness
- •Swelling in the legs
- •Rash
- •Dry, sore, or inflamed mouth; unusual taste
- •Joint or muscle pain
- •Dizziness
- •Hair loss
- •Bleeding (such as nosebleeds, blood in urine, or bruising)
- •Sleep problems
- •High protein levels in urine and urinary tract infections
- •Headache
- •Back pain
- •Red, sore, and swollen hands and feet
- •Underactive thyroid (symptoms like tiredness, weight gain, constipation, dry skin)
- •Low potassium or calcium levels in blood tests
- •Low white blood cell count
- •Changes in liver function tests
- •Low platelet count (may cause bruising and poor wound healing)
- •Low magnesium, high cholesterol, and high thyroid-stimulating hormone levels in blood tests
- •Changes in kidney function tests
- •High lipase and amylase levels in blood
- •Dehydration (loss of body fluids)
- •Palpitations (fast or strong heartbeat)
- •Dry, thickened, and itchy skin
- •Abdominal swelling or gas
- •Heart problems or blood clots in the lungs
- •Liver failure or signs of liver damage (e.g., yellow skin, tiredness, confusion)
- •General feeling of unwellness
- •Gallbladder inflammation
- •Stroke
- •Anal fistula (an abnormal passage near the anus)
- •Hole (perforation) in stomach or intestines
- •Low red blood cell count
- •Overactive thyroid (symptoms like fast heartbeat, sweating, weight loss)
- •Low blood pressure
- •Indigestion or digestion problems
- •Kidney failure
- •Colon inflammation
- •Decreased adrenal hormone production
RARE
- •Painful infection or irritation near the anus
- •Mini-stroke (TIA)
- •Severe pain in the upper left abdomen (may be associated with fever, chills, nausea, vomiting)
- •Wound healing problems
- •Jaw bone damage
- •Tumor lysis syndrome (a serious condition from dying cancer cells)
- •Other types of fistulas (abnormal connections between body parts or to the skin)
- •Enlarged, weakened, or torn blood vessels (aneurysms and arterial dissections)
Important Warnings
- Seek immediate medical help if you experience numbness or weakness on one side, severe headache, seizures, confusion, trouble speaking, vision changes, or dizziness, as these could be signs of a stroke or brain bleed.
- Contact a doctor right away if you have chest pain or pressure, pain in arms, back, neck, or jaw, shortness of breath, fast or uneven heartbeat, coughing, blue lips or fingers, or extreme tiredness, as these may indicate heart issues or a blood clot.
- Report severe stomach pain immediately, as it could be caused by a hole in the bowel wall or an abnormal connection (fistula).
- Tell your doctor if you have black, tarry, or bloody stools, or cough up blood, as these are signs of internal bleeding.
- Inform your doctor if your skin or the whites of your eyes turn yellow (jaundice), or if you feel very tired, confused, or have poor concentration, as these could be signs of liver problems.
Show 3 more warnings
- Contact your doctor if you have severe diarrhea, nausea, or vomiting, as these can lead to dehydration and kidney problems if not treated.
- Report any pain in your mouth, teeth, or jaw, swelling, sores in the mouth, numbness, heavy feeling in the jaw, or loose teeth, as these can be signs of jaw bone damage.
- Seek urgent medical advice if you experience nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, and tiredness, as these could be signs of tumor lysis syndrome.