Lenvatinib Avansor
Lenvatinib Avansor is a cancer medicine that slows down cancer cell growth by stopping blood vessel formation in tumors.
Form
kapseli, kova
Strength
4 mg
Active Ingredient
Lenvatinib besilate
Manufacturer
Avansor Pharma Oy
How to Use
Dosage
The usual dose varies depending on the type of cancer and your weight. For thyroid cancer, it's usually 24 mg once daily, for liver cancer 8-12 mg based on weight, and for endometrial cancer 20 mg once daily with another medicine. Your doctor may adjust your dose.
Method
Swallow the capsules whole with water, with or without food. Do not open the capsules. Take the capsules at approximately the same time each day.
Important
The highest recommended daily dose is usually 24 mg, but your doctor may adjust your dose.
Possible Side Effects
COMMON
- •High or low blood pressure
- •Loss of appetite or weight loss
- •Nausea and vomiting, constipation, diarrhea, stomach pain, indigestion, abdominal swelling or gas
- •Severe tiredness or weakness, feeling unwell
- •Hoarseness
- •Swelling of the legs or ankles
- •Rash
- •Dry, sore, or inflamed mouth, altered taste
- •Joint or muscle pain
- •Dizziness
- •Hair loss
- •Bleeding (like nosebleeds, blood in urine, bruises, gum bleeding, or intestinal bleeding)
- •Sleep problems
- •High protein in urine tests and urinary tract infections (more frequent and painful urination)
- •Headache
- •Back pain
- •Redness, soreness, and swelling of skin on hands and feet
- •Underactive thyroid (tiredness, weight gain, constipation, dry skin) or overactive thyroid (fast heartbeat, sweating, weight loss)
- •Low blood potassium, calcium, or magnesium; high cholesterol
- •Low white blood cells, low red blood cells, low platelets (can cause bruising and poor healing)
- •Changes in liver and kidney blood tests
- •High levels of digestive enzymes (lipase and amylase)
- •Dehydration (loss of body fluids)
- •Fast or strong heartbeat
- •Dry, thick, and itchy skin
- •Gallbladder inflammation
- •Stroke
- •Small abnormal passage near the anus (anal fistula)
- •Hole in the stomach or intestine
RARE
- •Painful infection or irritation near the anus
- •Mini-stroke (TIA)
- •Liver damage
- •Severe pain in upper left abdomen, possibly with fever, chills, nausea, and vomiting (spleen infarction)
- •Pancreatitis (inflammation of the pancreas)
- •Problems with wound healing
- •Jaw bone damage (osteonecrosis)
- •Colon inflammation (colitis)
- •Decreased hormone production by adrenal glands
- •Tumor lysis syndrome (TLS)
- •Severe breathing problems and chest pain from air leaking from a lung into the chest.
Important Warnings
- Do not take this medicine if you are allergic to lenvatinib or any of its other ingredients.
- Do not breastfeed if you are taking this medicine, as it can harm your baby.
- Tell your doctor if you have high blood pressure.
- Women who can become pregnant must use very reliable birth control during treatment and for one month after.
- Tell your doctor if you have had heart problems or a stroke.
Show 11 more warnings
- Tell your doctor if you have liver or kidney problems.
- Tell your doctor if you have recently had surgery or radiation therapy.
- Tell your doctor if you are planning major surgery, as this medicine can affect wound healing.
- Tell your doctor if you have had abnormal connections (fistulas) between different parts of your body.
- Tell your doctor if you have had a bulging or weakened blood vessel (aneurysm).
- Tell your doctor or dentist if you have pain, swelling, or other problems in your mouth, teeth, or jaw.
- Seek immediate medical help if you have numbness or weakness on one side of your body, severe headache, seizures, confusion, speech or vision problems, or dizziness. These could be signs of a stroke or brain bleed.
- Seek immediate medical help if you have chest pain or pressure, pain in your arms, back, neck, or jaw, shortness of breath, fast or irregular heartbeat, cough, blue lips or fingers, or severe tiredness. These could be signs of heart problems or a blood clot in the lungs.
- Seek immediate medical help if you have severe stomach pain, black or bloody stools, or cough up blood. These could be signs of a perforated bowel or internal bleeding.
- Seek immediate medical help if your skin or the whites of your eyes turn yellow, or if you feel tired, confused, or have trouble concentrating. These could be signs of liver problems.
- Seek immediate medical help if you have nausea, shortness of breath, irregular heartbeat, muscle cramps, seizures, cloudy urine, or fatigue. These could be signs of tumor lysis syndrome.