Lenalidomide Ratiopharm
Lenalidomide Ratiopharm is a medicine that helps your immune system fight certain blood cancers and also works directly against cancer cells.
Form
kapseli, kova
Strength
20 mg
Active Ingredient
Lenalidomide hydrochloride hydrate
Manufacturer
Teva B.V.
How to Use
Dosage
Your doctor will tell you how much medicine to take based on your specific treatment plan.
Method
Swallow the capsules whole with water. Do not break, open, or chew them. You can take the medicine with or without food, at about the same time each day as scheduled.
Important
The maximum daily dose will be determined by your doctor as part of your treatment cycles (either 21 or 28 days long).
Possible Side Effects
COMMON
- •Reduced red blood cells (anemia), causing tiredness and weakness.
- •Rashes and itching.
- •Muscle cramps, muscle weakness, muscle pain, bone pain, joint pain, back pain, and pain in limbs.
- •General swelling, including swelling in arms and legs.
- •Weakness and tiredness.
- •Fever and flu-like symptoms, including fever, muscle aches, headache, ear pain, cough, and chills.
- •Numbness, tingling or burning sensation in the skin, pain in hands or feet, dizziness, and tremor.
- •Reduced appetite and changes in taste.
- •Increased pain, tumor growth, or increased redness around the tumor.
- •Weight loss.
- •Constipation, diarrhea, nausea, vomiting, stomach pain, and heartburn.
- •Low potassium, calcium, and/or sodium levels in the blood.
- •Underactive thyroid.
- •Leg pain (could be a sign of a blood clot), chest pain or shortness of breath (could be signs of blood clots in the lungs).
- •All types of infections, including sinus, lung, and upper respiratory tract infections.
- •Shortness of breath.
- •Blurred vision and cloudy eye (cataract).
- •Kidney problems where kidneys do not work normally or maintain normal function.
- •Abnormal or increased liver function test results.
- •Changes in blood proteins that can cause swelling of blood vessels (vasculitis).
- •High or low blood sugar levels (diabetes).
- •Headache.
- •Nosebleeds.
- •Dry skin.
- •Depression, mood changes, and difficulty sleeping.
- •Cough.
- •Low blood pressure.
- •General discomfort or feeling unwell.
- •Sore and inflamed mouth, dry mouth.
- •Dehydration.
RARE
- •Destruction of red blood cells (hemolytic anemia).
- •Certain types of skin tumors.
- •Bleeding from gums, stomach, or intestines.
- •High blood pressure, slow, fast, or irregular heartbeat.
- •Increased levels of substances released from normal and abnormal breakdown of red blood cells.
- •Increased protein levels indicating inflammation in the body.
- •Darkening of the skin, skin discoloration due to bleeding under the skin (usually bruising), swelling of the skin due to bleeding, bruising.
- •Increased uric acid levels in the blood.
- •Skin symptoms, red skin, cracked skin, scaly or peeling skin, hives.
- •Increased sweating, night sweats.
- •Difficulty swallowing, sore throat, difficulty producing sound or voice changes, runny nose.
- •Significantly more or less urine than usual, or inability to control urination, blood in urine.
- •Shortness of breath, especially when lying down (which may be a symptom of heart failure).
- •Erectile dysfunction.
- •Stroke, fainting, vertigo (inner ear disorder causing a sensation of spinning surroundings), temporary loss of consciousness, chest pain radiating to arms, neck, jaw, back, or stomach, sweating and shortness of breath, nausea or vomiting (possible heart attack).
- •Muscle weakness, lack of strength, neck pain, chest pain, chills, joint swelling, thirst, toothache, falls.
- •Slowed or blocked bile flow from the liver, liver damage.
- •Low phosphate or magnesium in the blood.
- •Speech difficulties, balance problems, difficulty moving, deafness, ringing in the ears (tinnitus).
- •Nerve pain, unpleasant or abnormal sensations, especially when touched.
- •Excessive iron in the body.
- •Confusion.
- •Bleeding inside the skull.
- •Circulatory problems.
- •Loss of vision.
- •Loss of sex drive (libido).
- •Large amount of urine with bone pain and weakness, which can be symptoms of a kidney disorder (Fanconi syndrome).
- •Yellowing of skin, mucous membranes or eyes (jaundice), pale stools, dark urine, itchy skin, rash, stomach pain or swelling – these can be symptoms of liver damage (liver failure).
- •Stomach pain, swelling or diarrhea, which can be symptoms of large intestine inflammation (colitis or appendicitis).
- •Kidney cell damage (renal tubular necrosis).
- •Skin color changes, sensitivity to sunlight.
- •Tumor lysis syndrome – serious metabolic problems that can happen when cancer cells break down quickly, affecting blood chemistry and potentially causing kidney or heart issues.
- •High blood pressure in the blood vessels supplying the lungs (pulmonary hypertension).
- •Sudden or mild upper abdominal and/or back pain that lasts for several days, possibly with nausea, vomiting, fever, and fast heart rate (signs of pancreatitis).
- •Wheezing, shortness of breath, or dry cough (signs of lung inflammation).
- •Muscle breakdown (muscle pain, weakness or swelling), which can lead to kidney problems (rhabdomyolysis).
- •A skin disease caused by inflammation of small blood vessels, with joint pain and fever (leukocytoclastic vasculitis).
- •Breakdown of the stomach or intestine wall, which can lead to very serious infections.
- •Viral infections, including shingles (herpes zoster) and reactivated Hepatitis B infection.
- •Rejection of transplanted organs (e.g., kidney, heart).
Important Warnings
- Do not take this medicine if you are pregnant, think you might be pregnant, or are planning to become pregnant, as it can harm the baby.
- If you are a woman who can become pregnant, you must use effective birth control during treatment and for a specified time after.
- Men must use a condom during treatment and for at least 7 days after, even if vasectomized, if their partner is pregnant or could become pregnant and is not using effective birth control. Do not donate sperm.
- Do not take this medicine if you are allergic to lenalidomide or any other ingredients.
- Tell your doctor if you have a history of blood clots, as this medicine can increase your risk.
Show 10 more warnings
- Tell your doctor if you have signs of infection (like cough or fever) or if you have had a viral infection (like Hepatitis B, chickenpox, or HIV), as it might reactivate.
- Inform your doctor if you have kidney problems, as your dose may need to be adjusted.
- Tell your doctor if you have had a heart attack or blood clot, or if you smoke, have high blood pressure, or high cholesterol.
- Inform your doctor if you had an allergic reaction to thalidomide (another multiple myeloma medicine).
- Tell your doctor if you have had severe skin reactions in the past, like a widespread rash, red skin, high fever, flu-like symptoms, elevated liver enzymes, abnormal blood counts, or enlarged lymph nodes.
- Contact your doctor immediately if you experience blurred vision, vision loss, double vision, trouble speaking, weakness in an arm or leg, changes in walking or balance, constant numbness, loss of sensation, memory loss, or confusion, as these could be signs of a serious brain disease (PML).
- Report to your doctor if you have shortness of breath, tiredness, dizziness, chest pain, fast heartbeat, or swelling in your legs or ankles, as these can be signs of pulmonary hypertension.
- Do not donate blood during treatment or for at least 7 days after it ends.
- Do not breastfeed while using this medicine.
- Do not drive or use machines if you feel dizzy, tired, sleepy, have vertigo, or blurred vision after taking this medicine.