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Lenalidomide Grindeks

Lenalidomide Grindeks is a medicine used to treat multiple myeloma (a type of bone marrow cancer) and follicular lymphoma (a slow-growing lymph node cancer) in adults.

Form
kapseli, kova
Strength
5 mg
Active Ingredient
Lenalidomide ammonium chloride
Manufacturer
As Grindex

How to Use

Dosage

Your doctor will tell you the exact dose you need to take.

Method

Swallow the capsule whole with water. Do not break, open, or chew the capsule. You can take it with or without food. Take the medicine at about the same time each day, as directed by your doctor.

Important

Your doctor will determine your maximum daily dose.

Possible Side Effects

COMMON
  • •Decrease in red blood cells (anemia), white blood cells, or platelets, which can cause tiredness, weakness, infections, or bleeding.
  • •Rash, itching.
  • •Muscle cramps, muscle weakness, muscle pain, joint pain, back pain, bone pain, pain in arms and legs.
  • •General swelling, including swelling in arms and legs.
  • •Weakness, tiredness.
  • •Fever and flu-like symptoms, such as fever, muscle aches, headache, ear pain, cough, and chills.
  • •Numbness, tingling, burning sensation on skin, pain in hands or feet, dizziness, tremors.
  • •Decreased appetite, changes in taste, weight loss.
  • •Increased pain, growth in tumor size, or redness around the tumor.
  • •Constipation, diarrhea, nausea, vomiting, stomach pain, heartburn.
  • •Low levels of potassium, calcium, and/or sodium in the blood.
  • •Underactive thyroid gland.
  • •Leg pain (blood clot), chest pain, or shortness of breath (blood clot in the lungs).
  • •All types of infections, including sinus, lung, or upper respiratory tract infections.
  • •Shortness of breath.
  • •Blurred or decreased vision, cataracts (clouding of the eye).
  • •Kidney problems (kidneys not working properly).
  • •Abnormal or elevated liver enzyme values.
  • •Changes in blood protein that may cause blood vessel inflammation (vasculitis).
  • •High or low blood sugar.
  • •Headache.
  • •Nosebleed.
  • •Dry skin.
  • •Depression, mood changes, difficulty sleeping.
  • •Cough.
  • •Low blood pressure.
  • •General feeling of unwellness.
  • •Sore, inflamed mouth, dry mouth.
  • •Dehydration.
  • •Breakdown of red blood cells (hemolytic anemia).
  • •Certain types of skin tumors.
  • •Bleeding from gums, stomach, or intestines.
  • •High blood pressure, slow, fast, or irregular heartbeat.
  • •Increased substance resulting from normal and abnormal red blood cell breakdown.
  • •Increased body inflammation protein.
  • •Darkening of skin or discoloration due to bleeding, bruising, swelling.
  • •Increased uric acid in the blood.
  • •Skin symptoms, redness, flaking or peeling skin, hives.
  • •Increased sweating, night sweats.
  • •Difficulty swallowing, sore throat, voice quality problems or voice changes.
  • •Runny nose.
  • •Changes in urine amount, incontinence, blood in urine.
  • •Shortness of breath, especially when lying down (may be a symptom of heart failure).
  • •Erectile dysfunction.
  • •Stroke, fainting, vertigo (balance problems), temporary loss of consciousness.
  • •Chest pain radiating to arms, neck, jaw, back or stomach, sweating, shortness of breath, nausea or vomiting (symptoms of a heart attack).
  • •Muscle weakness, lack of energy.
  • •Neck pain, chest pain.
  • •Chills.
  • •Joint swelling.
  • •Slowed or blocked bile flow from the liver.
  • •Low phosphate or magnesium levels in the blood.
  • •Speech difficulties.
  • •Liver damage.
  • •Balance problems, difficulty moving.
  • •Deafness, ringing in the ears (tinnitus).
  • •Nerve pain, unpleasant, abnormal sensations especially when touched.
  • •Excess iron in the body.
  • •Thirst.
  • •Confusion.
  • •Toothache.
  • •Falls leading to injury.
RARE
  • •Bleeding inside the skull.
  • •Blood circulation problems.
  • •Loss of vision.
  • •Loss of sex drive (libido).
  • •Passing large amounts of urine, bone pain, and weakness (symptoms of a kidney disorder, Fanconi syndrome).
  • •Yellowing of skin, mucous membranes, or eyes (jaundice), pale stools, dark urine, itchy skin, rash, abdominal pain or swelling (symptoms of liver damage).
  • •Abdominal pain, swelling, or diarrhea (inflammation of the colon or appendix).
  • •Kidney cell damage (renal tubular necrosis).
  • •Skin discoloration, increased sensitivity to sunlight.
  • •Tumor lysis syndrome (metabolic complications from cancer treatment).
  • •Pulmonary hypertension (high blood pressure in the blood vessels supplying the lungs).
  • •Pancreatitis (sudden or worsening upper abdominal and/or back pain, nausea, vomiting, fever, fast heart rate).
  • •Lung tissue inflammation (wheezing, shortness of breath, dry cough).
  • •Muscle breakdown (muscle pain, weakness, or swelling) that can cause kidney problems (rhabdomyolysis).
  • •Skin disease caused by small blood vessel inflammation, with joint pain and fever (leukocytoclastic vasculitis).
  • •Rupture of the stomach or intestinal wall, which can lead to a very serious infection.
  • •Viral infections, such as shingles (herpes zoster) or reactivation of hepatitis B infection.
  • •Rejection of a solid organ transplant (such as a kidney or heart).

Important Warnings

  • Do not use this medicine if you are pregnant, think you might be pregnant, or are planning to become pregnant, as it can harm the unborn baby.
  • If you can become pregnant, you must use reliable contraception during and after taking this medicine.
  • Do not take if you are allergic to lenalidomide or any other ingredients in this medicine.
  • Tell your doctor immediately if you experience blurred vision, vision loss, double vision, speech problems, weakness in an arm or leg, changes in walking, balance problems, persistent numbness, loss of sensation, memory loss, or confusion, as these could be signs of a serious brain condition (PML).
  • Tell your doctor immediately if you experience shortness of breath, tiredness, dizziness, chest pain, a fast heartbeat, or swelling in your legs or ankles, as these could be signs of a serious lung condition called pulmonary hypertension.
Show 7 more warnings
  • Tell your doctor if you have had blood clots before, as this medicine increases the risk of blood clots.
  • Tell your doctor if you have signs of infection, such as a cough or fever.
  • Tell your doctor if you have or have had a viral infection, such as hepatitis B, chickenpox, or HIV, as the medicine might reactivate the virus.
  • Tell your doctor if you have kidney problems, as your dose might need to be adjusted.
  • Tell your doctor if you have had a heart attack or blood clot, if you smoke, or if you have high blood pressure or high cholesterol.
  • Tell your doctor if you have had an allergic reaction (like a rash or swelling) to thalidomide in the past.
  • Tell your doctor if you have had a severe skin reaction with widespread rash, fever, flu-like symptoms, and swollen lymph nodes (DRESS syndrome).

Additional Information

ATC Code: L04AX04
→ View Professional Information (PDF)→ View Patient Leaflet (PDF)