Lenalidomide Grindeks
Lenalidomide Grindeks helps treat blood cancers like multiple myeloma and follicular lymphoma by slowing cancer cell growth, stopping new blood vessels from feeding tumors, and boosting your immune system to fight cancer.
Form
kapseli, kova
Strength
2.5 mg
Active Ingredient
Lenalidomide ammonium chloride
Manufacturer
As Grindex
How to Use
Dosage
Your doctor will tell you how much Lenalidomide Grindeks to take, as the dose varies for each patient and treatment.
Method
Swallow the capsules whole, preferably with water. Do not break, open, or chew them. You can take them with or without food, at roughly the same time each day according to your treatment schedule.
Important
Your doctor will determine your maximum daily dose as part of your individual treatment plan.
Possible Side Effects
COMMON
- •Reduction in red blood cells (anemia), causing tiredness and weakness.
- •Skin rash, itching.
- •Muscle cramps, muscle weakness, muscle pain, bone pain, joint pain, back pain, arm and leg pain.
- •General swelling, including swelling in arms and legs.
- •Weakness, tiredness.
- •Fever and flu-like symptoms such as fever, muscle aches, headache, earache, cough, and chills.
- •Numbness, tingling or burning sensation on the skin, pain in hands or feet, dizziness, trembling.
- •Decreased appetite, changes in taste.
- •Increased pain, tumor size, or redness around the tumor.
- •Weight loss.
- •Constipation, diarrhea, nausea, vomiting, stomach pain, heartburn.
- •Low levels of potassium, calcium, and/or sodium in the blood.
- •Underactive thyroid.
- •Leg pain (possibly a sign of a blood clot), chest pain, or shortness of breath (possibly a sign of blood clots in the lungs, called pulmonary embolism).
- •All types of infections, including sinus infections, lung infections, and upper respiratory tract infections.
- •Shortness of breath.
- •Blurred or decreased vision.
- •Clouding of the eye (cataract).
- •Kidney problems, including decreased kidney function.
- •Abnormal liver test results.
- •Increased liver enzyme levels.
- •Changes in blood protein that can cause artery swelling (vasculitis).
- •High blood sugar (diabetes).
- •Low blood sugar.
- •Headache.
- •Nosebleeds.
- •Dry skin.
- •Depression, mood changes, sleep problems.
- •Cough.
- •Drop in blood pressure.
- •General feeling of discomfort, feeling unwell.
- •Sore inflamed mouth, dry mouth.
- •Dehydration.
- •Breakdown of red blood cells (hemolytic anemia).
- •Certain types of skin tumors.
- •Bleeding from gums, stomach, or intestines.
- •High blood pressure, slow, fast, or irregular heartbeat.
- •Increased amount of a substance resulting from normal and abnormal breakdown of red blood cells.
- •Increased levels of inflammation-indicating proteins in the body.
- •Darker skin, skin discoloration due to bleeding under the skin, often caused by bruises, skin swelling due to bleeding, bruising.
- •Increased uric acid levels in the blood.
- •Skin symptoms, redness of skin, cracking, flaking or peeling skin, hives.
- •Increased sweating, night sweats.
- •Difficulty swallowing, sore throat, problems with voice quality or voice changes.
- •Runny nose.
- •Producing much more or much less urine than usual, or inability to control urination, blood in urine.
- •Shortness of breath, especially when lying down (which can be a symptom of heart failure).
- •Erectile dysfunction.
- •Stroke, fainting, vertigo (inner ear problem causing dizziness), temporary loss of consciousness.
- •Chest pain radiating to arms, neck, jaw, back, or stomach, sweating, shortness of breath, nausea, or vomiting, which can be symptoms of a heart attack.
- •Muscle weakness, lack of energy.
- •Neck pain, chest pain.
- •Chills.
- •Joint swelling.
- •Slowed or blocked bile flow from the liver.
- •Low blood phosphate or magnesium levels.
- •Speech difficulties.
- •Liver damage.
- •Balance problems, difficulty moving.
- •Deafness, ringing in the ears (tinnitus).
- •Nerve pain, uncomfortable, unusual sensations, especially when touched.
- •Excess iron in the body.
- •Thirst.
- •Confusion.
- •Toothache.
- •Falls that may lead to injury.
RARE
- •Bleeding inside the skull.
- •Circulatory problems.
- •Loss of vision.
- •Loss of libido.
- •Large urine output with bone pain and weakness, which may be symptoms of a kidney disorder (Fanconi syndrome).
- •Yellowing of skin, mucous membranes, or eyes (jaundice), pale stools, dark urine, itchy skin, rash, abdominal pain, or abdominal swelling – these may be symptoms of liver damage (liver failure).
- •Abdominal pain, swelling, or diarrhea, which may be symptoms of colon inflammation (colitis or appendicitis).
- •Kidney cell damage (renal tubular necrosis).
- •Skin color changes, sensitivity to sunlight.
- •Tumor lysis syndrome – metabolic complications that can occur during cancer treatment and sometimes without treatment. This can lead to changes in blood chemistry (high potassium, phosphorus, uric acid, low calcium), kidney and heart rhythm problems, seizures, and sometimes death.
- •High blood pressure in the blood vessels supplying the lungs (pulmonary hypertension).
- •Sudden or mild but worsening upper abdominal and/or back pain that lasts for several days, possibly with nausea, vomiting, fever, and a rapid heart rate. These could be symptoms of pancreatitis.
- •Wheezing, shortness of breath, or dry cough, which may be symptoms of lung tissue inflammation.
- •Muscle tissue breakdown (muscle pain, weakness, or swelling), which can cause kidney problems (rhabdomyolysis), has been observed rarely, sometimes when Lenalidomide Grindeks was given with a statin (a cholesterol-lowering medicine).
- •Skin disease caused by small blood vessel inflammation, with joint pain and fever (leukocytoclastic vasculitis).
- •Stomach or intestinal wall breakdown. This can lead to very serious infections. Tell your doctor if you experience severe abdominal pain, fever, nausea, vomiting, bloody stools, or changes in bowel habits.
- •Viral infections, including shingles (a viral infection causing a painful blistering rash) and recurrence of Hepatitis B infection (which can cause yellow skin and eyes, dark brown urine, right-sided abdominal pain, fever, nausea, or vomiting).
- •Rejection of solid organ transplants (e.g., kidney, heart).
Important Warnings
- Do not take this medicine if you are pregnant, think you might be pregnant, or plan to become pregnant, as it can harm an unborn baby. Women who can get pregnant must use effective birth control. Men must use condoms during treatment and for 7 days after, even if vasectomized, if their partner is pregnant or could become pregnant. If you become pregnant during treatment, stop taking the medicine and tell your doctor right away.
- Do not take this medicine if you are allergic to lenalidomide or any other ingredient in this medicine.
- Tell your doctor if you have had blood clots before, as this medicine increases your risk of developing blood clots.
- Tell your doctor if you have signs of infection (like a cough or fever) or if you have had a viral infection (like Hepatitis B, chickenpox, or HIV) in the past. This medicine can reactivate past infections.
- Tell your doctor if you have kidney problems, as your doctor may need to adjust your dose.
Show 5 more warnings
- Tell your doctor if you have had a heart attack, blood clots, if you smoke, or if you have high blood pressure or high cholesterol.
- Seek immediate medical attention if you experience severe skin reactions such as widespread rash, red skin, high body temperature, flu-like symptoms, or swelling of the eyes, mouth, or face, as these can be life-threatening.
- Tell your doctor right away if you notice changes in your vision, speech, arm or leg weakness, balance problems, numbness, memory loss, or confusion, as these could be signs of a serious brain condition called PML.
- Tell your doctor right away if you experience shortness of breath, tiredness, dizziness, chest pain, a fast heartbeat, or swelling in your legs or ankles, as these could be signs of a serious lung condition called pulmonary hypertension.
- Do not donate blood during treatment or for at least 7 days after treatment ends.