Lamotrigin Orion
Lamotrigin Orion is a medicine used to treat epilepsy by stopping seizures and to help prevent depressive episodes in bipolar disorder.
How to Use
Dosage
For adults and children over 13 years old, the usual effective dose is between 100 mg and 400 mg per day. For children aged 2-12 years, the dose depends on their weight, typically 1-15 mg per kg per day, up to a maximum of 200 mg daily. Not recommended for children under 2 years old.
Method
Take your dose once or twice a day, with or without food, as directed by your doctor. You can swallow the dispersible tablet whole with a small amount of water, chew it, or dissolve it in water. If you chew it, drink some water to help it dissolve and ensure you swallow all the medicine. To dissolve, place the tablet in a glass with enough water to cover it, stir until dissolved, and drink all the liquid, adding a little more water to the glass to make sure you get all the medicine.
Never take more Lamotrigin Orion than your doctor tells you. The usual maximum for adults and children over 13 is 400 mg daily. For children aged 2-12, the maximum daily dose is 200 mg.
Possible Side Effects
- •Headache
- •Rash
- •Aggression or irritability
- •Tiredness or drowsiness
- •Dizziness
- •Tremor or shaking
- •Sleep problems (insomnia)
- •Agitation
- •Diarrhea
- •Dry mouth
- •Nausea or vomiting
- •Feeling tired
- •Back, joint, or other pain
- •Clumsiness and lack of coordination
- •Double vision or blurred vision
- •Unusual hair loss
- •Rash or sunburn after sun exposure (photosensitivity)
- •Skin reaction with red spots or patches that may look like a target (erythema multiforme)
- •Life-threatening skin reaction (Stevens-Johnson syndrome)
- •Symptoms including fever, nausea, vomiting, headache, stiff neck, and strong sensitivity to light (meningitis)
- •Fast, uncontrolled eye movements (nystagmus)
- •Itchy, watery eyes and rough eyelids (conjunctivitis)
- •Life-threatening skin reaction (toxic epidermal necrolysis)
- •Generalized eosinophilic syndrome (DRESS hypersensitivity syndrome)
- •High fever
- •Swelling of face (edema) or glands in neck, armpits, or groin (lymphadenopathy)
- •Liver function changes in blood tests or liver failure
- •Severe blood clotting disorder (DIC) causing unexpected bleeding or bruising
- •Hemophagocytic lymphohistiocytosis (HLH)
- •Blood test changes (low red blood cells, white blood cells, platelets, or all cell types; bone marrow disorder)
- •Hallucinations
- •Confusion
- •Unsteadiness when moving
- •Uncontrolled repetitive body movements or sounds (tics), muscle spasms (choreoathetosis), or other unusual movements like jerking, shaking, or stiffness
- •More frequent seizures in people who already have epilepsy
- •Worsening symptoms of Parkinson's disease
- •Lupus-like reactions (back/joint pain, fever, general illness)
- •Bone disorders (decreased bone density, osteoporosis, fractures)
- •Kidney inflammation (tubulointerstitial nephritis), potentially with eye inflammation (uveitis)
- •Nightmares
- •Weakened immune system (lower immunoglobulins)
- •Red lumps or patches on the skin (pseudolymphoma)
Important Warnings
- Do not take Lamotrigin Orion if you are allergic to lamotrigine or any other ingredients in this medicine.
- If you develop a severe skin rash (e.g., with blisters, peeling skin, or mouth sores), fever, or swollen glands, contact a doctor immediately as these can be life-threatening.
- Contact a doctor immediately if you experience fever, rash, or nervous system symptoms (like confusion or shaking) as these could be signs of a rare, severe immune reaction called HLH.
- If you have sad thoughts, feel worse, or have thoughts of harming yourself, contact your doctor as soon as possible or go to the nearest hospital.
- Tell your doctor if you have heart problems, especially if you have Brugada syndrome, as this medicine can affect your heart rhythm.
Show 4 more warnings
- If you are taking this medicine for epilepsy and your seizures become worse or happen more often, contact your doctor right away.
- Hormonal birth control (like the pill) can affect how Lamotrigin Orion works. Talk to your doctor about suitable birth control methods.
- If you are pregnant, planning to get pregnant, or breastfeeding, talk to your doctor or pharmacist before taking this medicine. Do not stop treatment without consulting your doctor.
- This medicine can cause dizziness and double vision. Do not drive or use machines until you are sure it does not affect you.
Use in Elderly Patients
Suitable for older adults, with specific precautions. Numerous potential adverse effects.. Consider common and sometimes serious adverse skin reactions. Reduce the dose in severe renal impairment. (updated 6.10.2025)