Lamotrigin Orion
Lamotrigine Orion is a medicine used to treat two conditions: epilepsy and bipolar disorder.
Form
dispergoituva tabletti
Strength
25 mg
Active Ingredient
Lamotrigine
Manufacturer
Orion Corporation
How to Use
Dosage
For adults and children over 13, the usual dose is 100-400 mg per day. For children aged 2-12, the dose depends on their weight, typically 1-15 mg per kg per day. This medicine is not for children under 2 years old.
Method
Take your dose once or twice a day, as prescribed by your doctor, with or without food. Always take the whole tablet; do not take only part of it. You can swallow the dispersible tablet whole with a little water, chew it, or dissolve it in water.
Important
Do not take more than 400 mg daily for adults, or more than 200 mg daily for children (2-12 years), as prescribed by your doctor.
Possible Side Effects
COMMON
- •Headache
- •Rash
- •Feeling aggressive or irritable
- •Tiredness or drowsiness
- •Dizziness
- •Shaking or tremor
- •Trouble sleeping
- •Feeling agitated
- •Diarrhea
- •Dry mouth
- •Nausea or vomiting
- •Feeling generally tired
- •Pain in your back, joints, or elsewhere
RARE
- •Clumsiness and lack of coordination
- •Double vision or blurred vision
- •Unusual hair loss
- •Rash or sunburn after sun exposure (photosensitivity)
- •Target-shaped skin rash with red spots or patches, a dark red center, and lighter red rings (erythema multiforme)
- •Life-threatening skin reaction (Stevens-Johnson syndrome)
- •Symptoms of meningitis, such as fever, nausea, vomiting, headache, stiff neck, and extreme sensitivity to bright light
- •Rapid, uncontrolled eye movements (nystagmus)
- •Itchy, watery eyes and crusty eyelids (conjunctivitis)
- •Very rare life-threatening skin reaction (toxic epidermal necrolysis)
- •Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)
- •High fever
- •Swelling of the face or glands in the neck, armpits, or groin (lymphadenopathy)
- •Changes in liver function tests or liver failure
- •Severe blood clotting disorder causing unexpected bleeding or bruising (DIC)
- •Hemophagocytic lymphohistiocytosis (HLH)
- •Changes in blood counts, such as fewer red blood cells (anemia), white blood cells (leukopenia, neutropenia, agranulocytosis), or platelets (thrombocytopenia), or problems with bone marrow (aplastic anemia)
- •Hallucinations (seeing or hearing things that are not real)
- •Confusion
- •Feeling unstable or wobbly when moving
- •Uncontrolled repetitive body movements or sounds (tics), muscle spasms affecting eyes, head, and body (choreoathetosis), or other unusual body movements like jerking, shaking, or stiffness
- •More frequent seizures for people who already have epilepsy
- •Worsening symptoms for people who already have Parkinson's disease
- •"Lupus-like" reactions (symptoms may include back or joint pain, sometimes with fever and/or feeling generally unwell)
- •Bone disorders like reduced bone density, weak bones (osteoporosis), and fractures have been reported
- •Kidney inflammation (tubulointerstitial nephritis), which may occur with eye inflammation (uveitis)
- •Nightmares
- •Weakened immune system due to lower levels of immunoglobulins (proteins that protect against infections)
- •Red lumps or spots on the skin (pseudolymphoma)
Important Warnings
- Do not take this medicine if you are allergic to lamotrigine or any other ingredient in it.
- Talk to your doctor if you have kidney problems.
- Talk to your doctor if you have ever had a rash after taking lamotrigine or other medicines for bipolar disorder or epilepsy.
- Talk to your doctor if you get a rash or sunburn after taking lamotrigine and being exposed to sunlight or artificial light (e.g., sunbeds).
- Talk to your doctor if you have previously developed meningitis (brain inflammation) after taking lamotrigine.
Show 12 more warnings
- Talk to your doctor if you are already taking any medicine that contains lamotrigine.
- Talk to your doctor if you have Brugada syndrome or other heart problems.
- Stop taking this medicine and contact your doctor immediately if you develop a severe allergic reaction or skin rash, as these can be life-threatening.
- This medicine can cause a rare but very serious immune system reaction called Hemophagocytic Lymphohistiocytosis (HLH). Contact your doctor immediately if you get a fever, rash, shaking, confusion, or brain problems.
- This medicine may increase the risk of suicidal thoughts. If you have any new or worsening thoughts of self-harm, contact your doctor immediately.
- If you take this medicine for epilepsy, your seizures might get worse or happen more often. Contact your doctor immediately if this happens.
- This medicine is not for people under 18 years old with bipolar disorder.
- Hormonal birth control (like birth control pills) can affect how this medicine works. Discuss contraception with your doctor.
- If you are pregnant, planning to become pregnant, or think you might be pregnant, talk to your doctor before using this medicine. Do not stop treatment without discussing it with your doctor.
- If you are breastfeeding or plan to breastfeed, talk to your doctor or pharmacist before taking this medicine.
- This medicine can cause dizziness and double vision. Do not drive or operate machinery until you know how it affects you.
- This medicine contains aspartame, which can be harmful for people with phenylketonuria (PKU).
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. Numerous potential adverse effects.. Consider common and sometimes serious adverse skin reactions. Reduce the dose in severe renal impairment. (updated 6.10.2025)