Ketipinor
Ketipinor is an antipsychotic medicine used to treat mood disorders like depression and mania, and schizophrenia.
Form
depottabletti
Strength
400 mg
Active Ingredient
Quetiapine fumarate
Manufacturer
Orion Corporation
How to Use
Dosage
Your doctor will decide your starting dose. The usual daily dose is between 150 mg and 800 mg, depending on your condition.
Method
Take tablets once a day with water, without food (at least 1 hour before a meal or at bedtime). Do not split, chew, or crush them. Avoid grapefruit juice and do not stop taking the medicine without talking to your doctor.
Important
The maximum daily dose is typically 800 mg.
Possible Side Effects
COMMON
- •Dizziness (may lead to falls)
- •Headache
- •Dry mouth
- •Drowsiness (may lessen with continued use, can lead to falls)
- •Withdrawal symptoms (e.g., trouble sleeping, nausea, headache, diarrhea, vomiting, dizziness, irritability) if stopping the medicine suddenly.
- •Weight gain
- •Abnormal muscle movements (e.g., trouble starting movements, shaking, restlessness, muscle stiffness without pain)
- •Changes in certain fat levels (triglycerides and total cholesterol)
- •Fast or pounding heartbeat, palpitations
- •Constipation, upset stomach (digestion problems)
- •Weakness
- •Swelling in arms or legs
- •Low blood pressure, especially when standing up, which can cause dizziness or fainting (may lead to falls)
- •High blood sugar
- •Blurred vision
- •Abnormal dreams and nightmares
- •Increased appetite
- •Irritability
- •Speech and language problems
- •Suicidal thoughts and worsening depression
- •Shortness of breath
- •Vomiting (mostly in elderly patients)
- •Fever
- •Changes in thyroid hormone levels in the blood
- •Decrease in certain types of blood cells
- •Increased liver enzymes measured in the blood
- •Increased prolactin hormone levels in the blood, which can rarely cause breast swelling in men and women, unexpected breast milk production, or missed/irregular periods in women.
RARE
- •Seizures or convulsions
- •Allergic reactions (e.g., hives, swelling of skin and mouth area)
- •Unpleasant feeling in legs (restless legs syndrome)
- •Difficulty swallowing
- •Uncontrolled movements (especially of the face or tongue)
- •Sexual dysfunction
- •Diabetes
- •Changes in heart's electrical activity (prolonged QT interval on ECG)
- •Slower than normal heart rate (especially at start of treatment), possibly with low blood pressure and fainting
- •Difficulty urinating
- •Fainting (may lead to falls)
- •Stuffy nose
- •Decrease in red blood cells
- •Decrease in sodium levels in the blood
- •Worsening of diabetes
- •Confusion
- •Neuroleptic malignant syndrome (a serious condition with fever, sweating, muscle stiffness, extreme drowsiness or weakness)
- •Yellow skin and eyes (jaundice)
- •Liver inflammation (hepatitis)
- •Long-lasting and painful erection (priapism)
- •Breast swelling and unexpected breast milk production (galactorrhea)
- •Menstrual problems
- •Blood clots, especially in leg veins (with swelling, pain, redness), which can travel to the lungs causing chest pain and breathing difficulties; seek immediate medical help.
- •Sleepwalking, sleep talking, sleep eating, or other sleep-related activities
- •Decreased body temperature (hypothermia)
- •Pancreatitis (inflammation of the pancreas)
- •Metabolic syndrome (a condition with at least three of these: increased belly fat, low "good" cholesterol, high triglycerides, high blood pressure, and high blood sugar)
- •Agranulocytosis (a serious condition with fever, flu-like symptoms, sore throat, or other infection, and a very low white blood cell count)
- •Bowel obstruction
- •Increased levels of creatine phosphokinase (a substance from muscles) in the blood
- •Severe rash, blisters, or red spots on the skin
- •Severe allergic reaction (anaphylactic shock), which can cause breathing difficulties or shock
- •Rapid swelling of the skin, usually around the eyes, lips, or throat (angioedema)
- •Severe blistering of the skin, mouth, eyes, or genital area (Stevens-Johnson syndrome)
- •Abnormal secretion of a hormone that regulates urine volume
- •Muscle fiber damage and muscle pain (rhabdomyolysis)
- •Rash with irregular red patches (erythema multiforme)
- •Acute generalized exanthematous pustulosis (AGEP), a reaction with rapidly appearing red skin areas filled with small pus-filled blisters.
- •Severe, sudden allergic reaction with symptoms like fever, skin blisters, and skin peeling (toxic epidermal necrolysis)
- •DRESS syndrome (a condition with flu-like symptoms, rash, fever, swollen lymph nodes, and abnormal blood test results)
- •Heart muscle disease (cardiomyopathy)
- •Heart muscle inflammation (myocarditis)
- •Blood vessel inflammation (vasculitis), often with small red or purple spots on the skin
- •Withdrawal symptoms in newborns if the mother used Ketipinor during pregnancy.
- •Stroke
Important Warnings
- Do not take Ketipinor if you are allergic to quetiapine or any other ingredients in this medicine.
- Do not use Ketipinor with certain medicines for HIV, fungal infections (azoles), bacterial infections (erythromycin or clarithromycin), or depression (nefazodone).
- Talk to your doctor if you are taking other antidepressants, as combining them with Ketipinor can cause a serious condition called serotonin syndrome.
- Inform your doctor about any heart problems you or your family have, low blood pressure, or if you take medicines that affect your heart rate.
- Tell your doctor if you have had a stroke (especially if you are elderly), have liver problems, or seizures.
Show 13 more warnings
- Tell your doctor if you have diabetes or are at risk of developing it; your blood sugar levels may need to be checked.
- Elderly people with dementia should not take Ketipinor due to an increased risk of stroke and, in some cases, death.
- If you or your family have a history of blood clots, as this type of medicine can increase the risk.
- Seek immediate medical attention if you experience fever, severe muscle stiffness, sweating, or decreased consciousness, as these could be signs of a serious condition.
- Report uncontrolled movements, especially of the face or tongue, to your doctor.
- Be aware that dizziness or severe drowsiness can increase the risk of falls, especially in elderly patients.
- Seek medical help if you experience a long-lasting, painful erection (priapism).
- Report fast or irregular heartbeats, palpitations, breathing difficulties, chest pain, or unexplained tiredness to your doctor immediately.
- Contact your doctor if you have fever, flu-like symptoms, sore throat, or other infections, as this could mean a low white blood cell count.
- Report constipation with persistent stomach pain or constipation that doesn't improve, as these can be signs of a serious bowel blockage.
- Stop taking Ketipinor and seek immediate medical help if you develop severe skin reactions like rashes, blisters, or skin peeling, as these can be life-threatening.
- Patients taking Ketipinor may gain weight; you and your doctor should regularly check your weight.
- Ketipinor is not for use in children and adolescents under 18 years of age.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. For treatment of psychosis only. Inappropriate as a hypnotic. Increases the risk of cardiovascular events, QT prolongation and orthostatic hypotension. Increases risk of falls, extrapyramidal symptoms and cognitive impairment. Reduces the effectiveness of drugs for Alzheimer’s disease. Avoid grapefruit. (updated 15.1.2024)