Ketipinor
Ketipinor is a medicine that helps treat mood disorders like depression, mania, and schizophrenia.
Form
depottabletti
Strength
300 mg
Active Ingredient
Quetiapine fumarate
Manufacturer
Orion Corporation
How to Use
Dosage
Your doctor will prescribe the correct dose for you, usually between 150 mg and 800 mg daily.
Method
Take the tablets whole with water once a day, at least one hour before a meal or at bedtime. Do not split, chew, or crush them. Avoid grapefruit juice during treatment.
Important
The maximum daily dose is typically 800 mg, but your doctor will determine your exact dose.
Possible Side Effects
COMMON
- •Dizziness (can lead to falls), headache, dry mouth.
- •Drowsiness (can lead to falls), which may lessen with continued treatment.
- •Symptoms after stopping the medicine, such as sleeplessness, nausea, headache, diarrhea, vomiting, dizziness, and irritability.
- •Weight gain.
- •Unusual muscle movements, such as difficulty starting movements, shaking, restlessness, or muscle stiffness without pain.
- •Changes in blood fat levels (triglycerides and cholesterol).
- •Fast pulse.
- •Palpitations (feeling your heart beat fast or irregularly).
- •Constipation, digestion problems.
- •Weakness.
- •Swelling in hands or feet.
- •Low blood pressure, especially when standing up, which can cause dizziness or faintness and lead to falls.
- •High blood sugar.
- •Blurred vision.
- •Unusual dreams and nightmares.
- •Increased appetite.
- •Irritability.
- •Speech problems.
- •Thoughts of suicide and worsening depression.
- •Shortness of breath.
- •Vomiting (mainly in elderly patients).
- •Fever.
- •Changes in thyroid hormone levels.
- •Decrease in certain types of blood cells.
- •Increased liver enzyme levels in the blood.
- •Increased prolactin hormone levels in the blood, which can cause breast swelling, unexpected milk production, or missed/irregular periods in women.
- •High blood pressure.
RARE
- •Seizures (epilepsy).
- •Allergic reactions, such as hives and swelling of the skin and around the mouth.
- •Restless legs syndrome (unpleasant sensation in the legs).
- •Difficulty swallowing.
- •Uncontrolled movements, especially in the face or tongue.
- •Sexual dysfunction.
- •Diabetes.
- •Changes in the heart's electrical activity (seen on ECG).
- •Slower heart rate, which may be accompanied by low blood pressure and fainting.
- •Difficulty urinating.
- •Fainting (can lead to falls).
- •Blocked nose.
- •Decrease in red blood cell count.
- •Decreased sodium levels in the blood.
- •Worsening of diabetes.
- •Confusion.
- •Combination of symptoms: fever, sweating, muscle stiffness, severe drowsiness, or fainting (neuroleptic malignant syndrome).
- •Yellowing of the skin and eyes (jaundice).
- •Liver inflammation (hepatitis).
- •Long-lasting and painful erection (priapism).
- •Breast swelling and unexpected milk production.
- •Menstrual disorders.
- •Blood clots, especially in the legs (swelling, pain, and redness), which can travel to the lungs causing chest pain and breathing difficulties.
- •Sleepwalking, sleep-talking, sleep-eating, or other activities while asleep.
- •Drop in body temperature (hypothermia).
- •Pancreatitis.
- •Metabolic syndrome, which includes three or more of the following: abdominal obesity, low 'good' cholesterol, high triglycerides, high blood pressure, and high blood sugar.
- •Combination of fever, flu-like symptoms, sore throat or other infections, and very low white blood cell count (agranulocytosis).
- •Intestinal blockage.
- •Increased levels of creatine phosphokinase (a substance from muscles) in the blood.
- •Severe rash, blisters, or red patches on the skin.
- •Severe allergic reaction (anaphylactic shock), which can cause breathing difficulties or shock.
- •Rapid swelling of the skin, usually around the eyes, lips, or throat (angioedema).
- •Severe blistering on the skin, in the mouth, eyes, or genital area (Stevens-Johnson syndrome).
- •Abnormal secretion of hormone that regulates urine volume.
- •Muscle breakdown and muscle pain (rhabdomyolysis).
- •Rash with irregular red patches (erythema multiforme).
- •Rapidly appearing red skin areas with small pus-filled blisters (acute generalized exanthematous pustulosis, AGEP).
- •Severe allergic reaction with fever, blisters, and peeling skin (toxic epidermal necrolysis).
- •Flu-like symptoms, rash, fever, swollen lymph nodes, and abnormal blood test results (DRESS syndrome).
- •Heart muscle disease (cardiomyopathy).
- •Inflammation of the heart muscle (myocarditis).
- •Blood vessel inflammation (vasculitis), often with a red or purple spotted rash.
- •Withdrawal symptoms in newborns if the mother used Ketipinor during pregnancy (e.g., tremors, muscle stiffness, drowsiness).
- •Stroke.
Important Warnings
- Do not use Ketipinor if you are allergic to quetiapine or any other ingredient in this medicine.
- Do not use Ketipinor if you are taking certain HIV medicines, antifungal medicines, erythromycin or clarithromycin (antibiotics), or nefazodone (an antidepressant).
- Tell your doctor if you have depression or are taking antidepressants, as using Ketipinor with them can cause a serious condition called serotonin syndrome.
- Tell your doctor if you or your family have a history of heart problems or if you are taking medicines that affect your heart rhythm.
- Tell your doctor if you have low blood pressure.
Show 26 more warnings
- Tell your doctor if you have had a stroke, especially if you are elderly.
- Tell your doctor if you have liver problems.
- Tell your doctor if you have had seizures (epilepsy).
- Tell your doctor if you have diabetes or are at risk of developing it. Your doctor will check your blood sugar during treatment.
- Tell your doctor if you have had low white blood cell counts.
- Tell your doctor if you are elderly and have dementia, as Ketipinor is not suitable for you and may increase the risk of stroke or death.
- Tell your doctor if you are elderly and have Parkinson's disease or parkinsonism.
- Tell your doctor if you or your family have a history of blood clots.
- Tell your doctor if you have sleep apnea or are taking medicines that slow down brain activity.
- Tell your doctor if you have trouble urinating, an enlarged prostate, a blocked intestine, or high pressure in your eye.
- Tell your doctor if you have had problems with alcohol or drug abuse.
- Contact your doctor immediately if you have fever, severe muscle stiffness, sweating, or decreased consciousness (a serious reaction called neuroleptic malignant syndrome).
- Contact your doctor immediately if you have uncontrolled movements, especially in your face or tongue.
- Contact your doctor immediately if you feel dizzy or very sleepy, which can lead to falls, especially in elderly patients.
- Contact your doctor immediately if you have seizures (epilepsy).
- Contact your doctor immediately if you have a long-lasting, painful erection (priapism).
- Contact your doctor immediately if you have a fast or irregular heartbeat, palpitations, breathing difficulties, chest pain, or unexplained tiredness.
- Tell your doctor as soon as possible if you have fever, flu-like symptoms, sore throat, or other infections, as this may be due to low white blood cell count.
- Tell your doctor as soon as possible if you have long-lasting constipation and stomach pain that doesn't improve with treatment, as it could be a sign of a blocked intestine.
- If you are depressed and have thoughts of harming yourself or suicide, contact your doctor immediately.
- If you develop severe skin reactions, such as widespread rash, blisters, or peeling skin, stop Ketipinor and contact your doctor immediately.
- Ketipinor can cause weight gain, so you and your doctor should regularly monitor your weight.
- Ketipinor is not suitable for children or adolescents under 18 years of age.
- Avoid alcohol during Ketipinor treatment, as it can increase drowsiness.
- Do not use Ketipinor if you are pregnant or breastfeeding, unless your doctor has advised otherwise.
- Ketipinor can make you sleepy. Do not drive or use machines until you know how the medicine affects you.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. For treatment of psychosis only. Inappropriate as a hypnotic. Increases the risk of cardiovascular events, QT prolongation and orthostatic hypotension. Increases risk of falls, extrapyramidal symptoms and cognitive impairment. Reduces the effectiveness of drugs for Alzheimer’s disease. Avoid grapefruit. (updated 15.1.2024)