Ketipinor
Ketipinor is a medicine used to treat mental health conditions like bipolar disorder and schizophrenia.
Form
tabletti, kalvopäällysteinen
Strength
25 mg
Active Ingredient
Quetiapine fumarate
Manufacturer
Orion Corporation
How to Use
Dosage
Your doctor will decide your dose, which usually ranges from 150 mg to 800 mg daily, depending on your condition.
Method
Take the tablets once a day at bedtime or twice a day, whole with water, with or without food. Do not drink grapefruit juice. Do not stop taking your medicine without talking to your doctor.
Important
The usual maximum daily dose is 800 mg, but your doctor will set your specific limit.
Possible Side Effects
COMMON
- •Dizziness (may lead to falls)
- •Headache
- •Dry mouth
- •Drowsiness (this may lessen with continued use of Ketipinor)
- •Withdrawal symptoms (when stopping Ketipinor), such as difficulty sleeping, nausea, headache, diarrhea, vomiting, dizziness, and irritability; gradual discontinuation over 1-2 weeks is recommended.
- •Weight gain
- •Abnormal muscle movements (difficulty starting movements, shaking, restlessness, or muscle stiffness without pain)
- •Changes in certain fat levels (triglycerides and total cholesterol)
- •Fast heartbeat
- •Palpitations (pounding or fluttering heart)
- •Constipation, indigestion (stomach problems)
- •Weakness
- •Swelling of arms or legs
- •Low blood pressure, especially when standing up (may cause dizziness or fainting, leading to falls)
- •High blood sugar
- •Vision problems
- •Abnormal dreams and nightmares
- •Increased appetite
- •Irritability
- •Speech and language problems
- •Suicidal thoughts and worsening depression
- •Shortness of breath
- •Vomiting (mainly in the elderly)
- •Fever
- •Changes in blood thyroid hormone levels
- •Decrease in certain types of blood cells
- •Increase in liver enzymes (measured in blood)
- •Increased prolactin hormone in the blood (can rarely cause breast swelling in men and women, unexpected milk production, or missed/irregular periods in women)
RARE
- •Seizures or cramps
- •Allergic reactions (hives, swelling of skin and around mouth)
- •Restless legs syndrome (unpleasant sensation in legs)
- •Difficulty swallowing
- •Uncontrolled movements (especially of the face or tongue)
- •Sexual dysfunction
- •Diabetes (worsening or new onset)
- •Changes in heart's electrical activity (prolonged QT interval on ECG)
- •Slower than normal heart rate (especially at start of treatment, may be linked to low blood pressure and fainting)
- •Difficulty urinating
- •Fainting (may lead to falls)
- •Stuffy nose
- •Decrease in red blood cells
- •Decreased sodium in blood
- •Confusion
- •Severe fever, sweating, muscle stiffness, significant drowsiness or fainting (neuroleptic malignant syndrome)
- •Yellowing of skin and eyes (jaundice)
- •Liver inflammation (hepatitis)
- •Prolonged and painful erection (priapism)
- •Breast swelling and unexpected milk production (galactorrhea)
- •Menstrual disorders
- •Blood clots in veins, especially in legs (swelling, pain, redness), which can travel to the lungs causing chest pain and breathing difficulties; seek immediate medical attention if these symptoms occur.
- •Sleepwalking, talking, eating, or other activities while asleep
- •Low body temperature (hypothermia)
- •Inflammation of the pancreas (pancreatitis)
- •Metabolic syndrome (combination of at least 3: belly fat, low 'good' cholesterol, high triglycerides, high blood pressure, high blood sugar)
- •Severe decrease in white blood cells (agranulocytosis), combined with fever, flu-like symptoms, sore throat, or other infection
- •Bowel obstruction
- •Increased creatine phosphokinase (substance from muscles) in blood
- •Severe rash, blisters or red patches on skin
- •Severe allergic reaction (anaphylactic shock) causing breathing difficulties or shock
- •Sudden swelling of skin, typically around eyes, lips or throat (angioedema)
- •Severe skin disease with blistering of the skin, mouth, eyes and genitals (Stevens-Johnson syndrome)
- •Abnormal secretion of hormone regulating urine volume
- •Muscle fiber breakdown and muscle pain (rhabdomyolysis)
- •Rash with irregular red patches (erythema multiforme)
- •Sudden appearance of red skin areas full of small pus-filled blisters (acute generalized exanthematous pustulosis, AGEP)
- •Severe, sudden allergic reaction with symptoms like fever, skin blisters and peeling skin (toxic epidermal necrolysis)
- •Drug rash with eosinophilia and systemic symptoms (DRESS) with flu-like symptoms, rash, fever, enlarged lymph nodes, and abnormal blood counts (including high white blood cells and liver enzymes)
- •Heart muscle disease (cardiomyopathy)
- •Inflammation of the heart muscle (myocarditis)
- •Inflammation of blood vessels (vasculitis), often with small red or purple skin bumps
- •Withdrawal symptoms in newborns if mother used Ketipinor during pregnancy
- •Stroke
Important Warnings
- Do not take Ketipinor if you are allergic to quetiapine or any other ingredients in this medicine.
- Do not take Ketipinor if you are also taking certain medicines for HIV, fungal infections (azoles), antibiotics like erythromycin or claritromycin, or the antidepressant nefazodone.
- Tell your doctor if you are taking antidepressants, as combining them with Ketipinor can cause a dangerous condition called serotonin syndrome.
- Inform your doctor if you or your family have a history of heart problems (like irregular heartbeat or weak heart muscle) or if you take medicines that affect your heart rate.
- Tell your doctor if you have low blood pressure.
Show 23 more warnings
- Tell your doctor if you have had a stroke, especially if you are elderly.
- Tell your doctor if you have liver problems.
- Tell your doctor if you have ever had seizures (epilepsy).
- Tell your doctor if you have diabetes or are at risk of getting it; your doctor will check your blood sugar during Ketipinor treatment.
- Tell your doctor if you have previously had low white blood cell count (which may have been caused by other medicines).
- Do not take Ketipinor if you are an elderly person with dementia, as it may increase the risk of stroke or death.
- Tell your doctor if you are an elderly person with Parkinson's disease.
- Tell your doctor if you or a family member have a history of blood clots, as medicines like Ketipinor can increase this risk.
- Tell your doctor if you have or have had sleep apnea or take medicines that slow down brain activity (CNS depressants).
- Tell your doctor if you have difficulty emptying your bladder, an enlarged prostate, a blocked intestine, or high eye pressure, especially if you take anticholinergic medicines.
- Tell your doctor if you have a history of alcohol or drug abuse.
- Seek immediate medical help if you have fever, severe muscle stiffness, sweating, or decreased consciousness all at once (called neuroleptic malignant syndrome).
- Seek immediate medical help if you have uncontrolled movements, especially of your face or tongue.
- Seek immediate medical help if you feel dizzy or very drowsy, which can increase the risk of falls in elderly patients.
- Seek immediate medical help if you have seizures.
- Seek immediate medical help if you have a prolonged and painful erection (priapism).
- Seek immediate medical help if you experience a fast or irregular heartbeat, even at rest, palpitations, breathing difficulties, chest pain, or unexplained tiredness; your doctor may refer you to a heart specialist.
- Tell your doctor as soon as possible if you have fever, flu-like symptoms, sore throat, or other infection, as this could be due to a very low white blood cell count and may require stopping Ketipinor.
- Tell your doctor as soon as possible if you have constipation and long-lasting stomach pain or constipation that hasn't improved with treatment, as this could lead to a serious bowel blockage.
- If you are depressed, you might sometimes have thoughts of harming yourself or committing suicide. Contact your doctor immediately if you have such thoughts.
- Stop taking Ketipinor and contact your doctor immediately if you develop severe skin reactions like rashes, blisters, peeling skin, fever, or flu-like symptoms, as these can be life-threatening.
- Weight gain has been observed in patients taking Ketipinor; your weight should be monitored regularly by you and your doctor.
- Ketipinor should not be used by children and adolescents under 18 years of age.
Use in Elderly Patients
Category D
Avoid use in older adults. Anticholinergic. Sedative. For treatment of psychosis only. Inappropriate as a hypnotic. Increases the risk of cardiovascular events, QT prolongation and orthostatic hypotension. Increases risk of falls, extrapyramidal symptoms and cognitive impairment. Reduces the effectiveness of drugs for Alzheimer’s disease. Avoid grapefruit. (updated 15.1.2024)