Ketesse

Ketesse is a pain-relieving medicine from the NSAID group, used to treat moderate to severe acute pain when oral tablets are not suitable, such as after surgery or for kidney stone pain.

Form
injektio-/infuusioneste, liuos
Strength
50 mg / 2 ml
Active Ingredient
Dexketoprofen trometamol
Manufacturer
Menarini International Operations Luxembourg S.A.

How to Use

Dosage

Usually, one Ketesse ampoule (50 mg) every 8-12 hours.

Method

This medicine is given as an injection into a muscle or slowly into a vein by a healthcare professional. You should switch to oral pain relief as soon as possible.

Important

The total dose should not be more than 150 mg (3 ampoules) per day. For elderly patients or those with kidney or liver problems, the maximum daily dose is 50 mg (1 ampoule).

Possible Side Effects

COMMON
  • Nausea and/or vomiting
  • Pain at the injection site
  • Injection site reaction (e.g., inflammation, bruising, or bleeding)
RARE
  • Vomiting blood
  • Low blood pressure
  • Fever
  • Blurred vision
  • Dizziness
  • Drowsiness or sleep problems
  • Headache
  • Anemia (low red blood cells)
  • Stomach pain
  • Constipation
  • Indigestion or diarrhea
  • Dry mouth
  • Redness of skin or rash
  • Itching
  • Increased sweating
  • Fatigue or pain
  • Chills
  • Stomach ulcer, bleeding or perforated ulcer
  • High blood pressure
  • Fainting
  • Slowed breathing rate
  • Inflammation of a surface vein due to a blood clot (superficial thrombophlebitis)
  • Heart rhythm problems (extra beats) or fast heartbeat
  • Swollen arms and legs (peripheral edema)
  • Throat swelling (laryngeal edema)
  • Loss of appetite (anorexia)
  • Abnormal sensations
  • Feverish feeling and shivers
  • Ringing in ears (tinnitus)
  • Itchy rash
  • Yellow skin or eyes (jaundice)
  • Acne
  • Back or kidney pain
  • Increased urination or menstrual problems
  • Prostate problems
  • Stiff muscles or joints, muscle cramps
  • Abnormal blood test results (e.g., liver values, blood sugar, blood fats)
  • Ketones or protein in urine
  • Liver cell damage (hepatitis)
  • Acute kidney failure
  • Severe allergic reaction (anaphylaxis) which can lead to collapse
  • Skin, mouth, eye, and genital ulcers (Stevens-Johnson and Lyell's syndrome)
  • Swelling of the face, tongue, and throat (angioedema)
  • Breathing difficulties due to muscle spasms in the airways (bronchospasm) or shortness of breath
  • Pancreatitis (inflammation of the pancreas)
  • Skin reactions and sensitivity to sunlight
  • Kidney damage
  • Decreased white blood cells (neutropenia) or platelets (thrombocytopenia)

Important Warnings

  • Do not use Ketesse if you are allergic to dexketoprofen, aspirin, or other similar pain relievers (NSAIDs).
  • Do not use if you have asthma, severe allergic reactions, swelling of the face/throat, or breathing problems after taking NSAIDs or aspirin.
  • Do not use if you have stomach ulcers, bleeding in the stomach or gut, or severe digestive problems like Crohn's disease or ulcerative colitis.
  • Do not use if you have severe heart, kidney, or liver failure, or problems with blood clotting.
  • Do not use if you are severely dehydrated (lost a lot of fluids from vomiting or diarrhea).
Show 8 more warnings
  • Do not use Ketesse during the last 3 months of pregnancy or if you are breastfeeding.
  • Ketesse should not be used in children and adolescents under 18 years of age.
  • Ketesse can hide signs of infection, like fever and pain. If your infection symptoms worsen, contact your doctor immediately. Avoid during chickenpox.
  • Stop taking Ketesse immediately if you develop a skin rash, any sores on your mouth or other mucous membranes, or any signs of an allergic reaction.
  • This medicine may make you feel dizzy or tired. Do not drive or operate machinery until you feel normal again.
  • Long-term use of NSAIDs can lead to fluid retention, high blood pressure, and worsen heart failure.
  • Ketesse may slightly increase the risk of a heart attack or stroke, especially with high doses or long-term use. Do not take more than recommended.
  • Elderly patients are more likely to experience side effects, especially stomach and gut problems, which can sometimes be serious. Contact your doctor immediately if you have stomach pain, heartburn, or bleeding.

Use in Elderly Patients

Category C

Suitable for older adults, with specific precautions. For short-term use only. Consider adverse renal effect in chronic kidney disease. Avoid use in moderately severe renal impairment. Increases swelling, worsens renal and heart failure and causes cardiovascular events. Increases risk of bleeding, especially in the gastrointestinal tract. Consider potential interactions especially with preparations that increase risk of bleeding. (updated 16.9.2024)