Injexate
Injexate contains methotrexate, which helps slow down the progression of certain diseases like rheumatoid arthritis and psoriasis by reducing inflammation and immune system activity.
Form
injektioneste, liuos, esitäytetty injektori
Strength
30 mg
Active Ingredient
Methotrexate
Manufacturer
Accord Healthcare B.V.
How to Use
Dosage
Your doctor will decide the right dose for you, which is adjusted individually.
Method
This medicine is given as an injection under the skin, only once a week. A healthcare professional will teach you how to inject it correctly.
Important
Take this medicine only once a week; taking too much can be life-threatening.
Possible Side Effects
COMMON
- •Inflammation inside the mouth, upset stomach, feeling sick, not wanting to eat, stomach pain.
- •Blood tests showing abnormal liver function.
- •Sores in the mouth, loose stools.
- •Skin rash, red skin, itchy skin.
- •Headache, feeling tired, feeling sleepy.
- •Fewer white or red blood cells and/or platelets (parts of blood that help it clot).
- •Persistent dry cough, shortness of breath, fever (signs of lung inflammation).
RARE
- •Spitting or coughing up blood (possible lung bleeding).
- •Signs of liver damage, such as yellow skin or eyes (jaundice), liver scarring, fatty liver, liver inflammation, or liver failure.
- •Severe allergic reactions like widespread skin rash, itching, redness, swelling of hands, feet, ankles, face, lips, mouth, or throat, or feeling faint.
- •Signs of kidney damage, such as swelling in hands, ankles, or feet, changes in how often you pee, or peeing less than usual or not at all.
- •Signs of severe infection like high fever, chills, body aches, sore throat, or severe infections such as a specific type of lung infection (Pneumocystis jirovecii pneumonia) or blood poisoning (sepsis).
- •Symptoms like weakness on one side of the body (stroke), pain, swelling, redness, and unusual warmth in one leg (deep vein thrombosis), or a blood clot blocking a blood vessel.
- •Fever and very bad general health, or sudden fever with sore throat, mouth sores, or problems peeing, or unexpected bleeding (from gums, in urine, vomiting blood, bruising). These can be signs of very low white blood cells or platelets.
- •Severe headache, often with fever, stiff neck, nausea, vomiting, confusion, memory problems, sensitivity to light (meningitis-like symptoms), or changes in mental state, problems with movement, vision, or memory (signs of brain disease).
- •Severe skin rash or blisters (can also appear in the mouth, eyes, and genitals), which might be very serious skin conditions (Stevens-Johnson syndrome or toxic epidermal necrolysis).
- •Sore throat (pharyngitis).
- •Inflammation in the gut, throwing up, inflammation of the pancreas, black or tarry poop, sores or bleeding in the stomach or gut.
- •Sunburn-like reactions from increased sun sensitivity, hair loss, increased rheumatic nodules, skin ulcers, shingles (painful rash), inflamed blood vessels, herpes-like rash, hives.
- •Developing diabetes as an adult.
- •Feeling dizzy, confused, or depressed.
- •Lower levels of protein (albumin) in the blood.
- •Fewer of all types of blood cells and platelets.
- •Inflammation or sores in the bladder or vagina, kidney problems, trouble peeing.
- •Aching joints, sore muscles, weaker bones.
- •Swollen or sore gums.
- •Skin getting darker, acne, small blue spots on skin from bleeding (bruises/petechiae), allergic swelling of blood vessels.
- •Lower levels of protective antibodies in your blood.
- •Infection (including old, hidden infections coming back), red eyes (conjunctivitis).
- •Changes in mood.
- •Problems with eyesight.
- •Inflammation of the sac around the heart, fluid buildup around the heart, pressure on the heart from this fluid.
- •Low blood pressure.
- •Scarring of the lungs, feeling short of breath, asthma-like symptoms, fluid in the space around the lungs.
- •Small bone break from stress.
- •Imbalance of salts (electrolytes) in the body.
- •Fever, wounds taking longer to heal.
- •A severe swelling of the large intestine.
- •Nails changing color, inflammation of skin around nails, deep skin infections (boils), small blood vessels visible on skin.
- •Damage at the injection site (like sterile bumps or changes in fat tissue).
- •Pain, feeling numb or tingling, weakness, metallic taste in mouth, seizures, paralysis (inability to move part of body), meningitis-like symptoms (stiff neck, headache).
- •Worsening eyesight, an eye disease not caused by inflammation.
- •Less interest in sex, inability to get an erection, breast growth in men, problems with sperm production, irregular periods, vaginal discharge.
- •Swollen lymph nodes (lymphoma).
- •Unusual growth of white blood cells (lymphoproliferative disorders).
- •An increase in certain white blood cells.
- •Bleeding from the nose.
- •Protein found in urine.
- •Feeling weak.
- •Damage to the jaw bone.
- •Red and peeling skin.
- •Swelling.
- •Tissue damage at the injection site.
Important Warnings
- Do not use Injexate if you are allergic to methotrexate or any other ingredient in this medicine.
- Do not use Injexate if you are pregnant, breastfeeding, or planning to become pregnant or father a child within a specific timeframe (6 months for women, 3 months for men).
- Take Injexate only once a week. Taking too much can be very dangerous and even deadly.
- Avoid alcohol and large amounts of coffee, caffeinated drinks, and black tea while taking Injexate.
- Do not inject yourself unless a healthcare professional has taught you the correct injection technique.
Show 7 more warnings
- Contact your doctor immediately if you or your partner notice new or worsening neurological symptoms, such as muscle weakness, vision problems, or confusion.
- Contact your doctor immediately if you cough or spit up blood.
- If you have diarrhea, tell your doctor, as treatment might need to be stopped.
- Protect your skin from strong sunlight and avoid solariums while on Injexate treatment.
- Avoid live vaccines during Injexate treatment.
- Never take a double dose to make up for a missed one.
- Do not stop Injexate treatment without first talking to your doctor.
Use in Elderly Patients
Category C
Suitable for older adults, with specific precautions. For the treatment of conditions other than cancer only once weekly. Organtoxic such as kidneys, liver and bone marrow. Reduce the dose already in mild renal impairment. Avoid use in severe renal impairment. Consider the numerous potential interactions. Remember blood tests to monitor safety. (updated 6.11.2023)